scholarly journals Long-Term Survival after Radical Resection for Pancreatic Head and Ampullary Cancer: A Potential Role for the EGF-R

2007 ◽  
Vol 24 (1) ◽  
pp. 38-45 ◽  
Author(s):  
H.G. Smeenk ◽  
J. Erdmann ◽  
H. van Dekken ◽  
R. van Marion ◽  
W.C.J. Hop ◽  
...  
Keyword(s):  
Potential Role ◽  
Pancreatic Head ◽  
Radical Resection ◽  
Ampullary Cancer ◽  
Term Survival ◽  
Long Term Survival

Perioperative glucocorticoids are associated with improved long-term survival after pancreatic cancer surgery: A retrospective cohort study

2020 ◽  
Author(s):  
Yun-Xiao Zhang ◽  
Dong-Liang Mu ◽  
Ke-Min Jin ◽  
Xue-Ying Li ◽  
Dong-Xin Wang
Keyword(s):  
Pancreatic Cancer ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Radical Surgery ◽  
Radical Resection ◽  
Cancer Surgery ◽  
Term Survival ◽  
Long Term Survival

Abstract Background Perioperative anesthetic management may affect long-term outcome after cancer surgery. This study aimed to investigate the effect of perioperative glucocorticoids on long-term survival in patients after radical resection for pancreatic cancer.Methods In this retrospective cohort study, patients who underwent radical resection for pancreatic cancer from January 2005 to December 2016 were recruited. Baseline and perioperative data including use of glucocorticoids for prevention of postoperative nausea and vomiting were collected. Patients were followed up for tumor recurrence and survival. The primary outcome was the overall survival (OS); the secondary outcome was the recurrence-free survival (RFS). A multivariable Cox proportional hazard model was used to analyze the influence of perioperative glucocorticoid use on OS and RFS after correction for confounding factors.Results A total of 215 patients after radical surgery for pancreatic cancer were included in the study; of these, 112 received perioperative glucocorticoids and 103 did not. Patients were followed up for a median of 74.0 months (95% confidence interval [CI] 68.3-79.7). Both OS and RFS were significantly longer in patients with glucocorticoids than in those without (for OS: median 19.7 months [95% CI 12.3-36.2] vs. 13.9 months [8.0-23.9], P=0.001; for RFS: 12.0 months [6.0-28.0] vs. 6.9 months [4.2-17.0], P=0.002). After correction for confounding factors, perioperative glucocorticoids were significantly associated with prolonged OS (HR 0.692, 95% CI 0.499-0.959, P=0.027) and RFS (HR 0.634, 95% CI 0.459-0.878, P=0.006).Conclusions Perioperative use of low-dose glucocorticoids may improve long-term survival in patients undergoing radical surgery for pancreatic cancer.

The Long-Term Survival of Patients with Ductal Carcinoma of the Pancreatic Head and Body

1997 ◽  
pp. 143-150
Author(s):  
Hisashi Mimura ◽  
Masanobu Mori ◽  
Takuji Mimura ◽  
Keisuke Hamazaki ◽  
Hiromu Tsuge
Keyword(s):  
Ductal Carcinoma ◽  
Pancreatic Head ◽  
Term Survival ◽  
Long Term Survival

Histological Evidence that Microsclerotia Play a Significant Role in Disease Cycle of the Boxwood Blight Pathogen in Southeastern United States and Implications for Disease Mitigation

2012 ◽  
Vol 13 (1) ◽  
pp. 45 ◽  
Author(s):  
Sarah M. Weeda ◽  
Norman L. Dart
Keyword(s):  
United States ◽  
Significant Role ◽  
Potential Role ◽  
Histological Study ◽  
Southeastern United States ◽  
Host Tissue ◽  
Term Survival ◽  
Long Term Survival ◽  
Histological Evidence

Cylindrocladium pseudonaviculatum, the causal agent of box blight, has been shown to survive in soil for at least 5 years. The occurrence of microsclerotia in host tissue remains undocumented, making the mechanism for long term survival of this pathogen unclear. If the boxwood blight pathogen has indeed lost or never evolved the ability to produce microslerotia in tissues, one could infer that the pathogen is either less equipped for long term survival in soil than other Cylindrocladium species or the pathogen has evolved another mechanism to enable it to persist in soil. Based on these assumptions, we conducted a histological study to determine the potential role, if any, of microsclerotia in the lifecycle of C. pseudonaviculatum. Accepted for publication 17 February 2012. Published 3 April 2012.

Does preoperative biliary drainage compromise the long-term survival of patients with pancreatic head carcinoma?

2014 ◽  
Vol 111 (3) ◽  
pp. 270-276 ◽  
Author(s):  
Yoshiaki Murakami ◽  
Kenichiro Uemura ◽  
Yasushi Hashimoto ◽  
Naru Kondo ◽  
Naoya Nakagawa ◽  
...  
Keyword(s):  
Biliary Drainage ◽  
Pancreatic Head ◽  
Preoperative Biliary Drainage ◽  
Term Survival ◽  
Long Term Survival ◽  
Pancreatic Head Carcinoma

scholarly journals Radical Versus Non-Radical Resection for Small intestinal Gastrointestinal Stromal Tumors: A Propensity Score-Matched Analysis

2021 ◽  
Author(s):  
Linlin Yin ◽  
Haihao Yan ◽  
Jue Lin ◽  
Zuhong Ji ◽  
Guozhong Ji ◽  
...  
Keyword(s):  
Propensity Score ◽  
Gastrointestinal Stromal Tumors ◽  
Radical Surgery ◽  
Radical Resection ◽  
Term Survival ◽  
Long Term Survival ◽  
Resection Group ◽  
Stromal Tumors ◽  
Small Intestinal

Abstract Surgical resection is the first choice for the treatment of small intestinal gastrointestinal stromal tumors (GISTs), but the best surgical method for small intestinal stromal tumors remains undefined. It is not clear whether there is a difference in the long-term survival of small intestinal GISTs between radical surgery and non-radical surgery. We included 877 patients with small intestinal stromal tumors who underwent surgery between 2010 and 2015 from the SEER database. They were divided into the radical resection group and the non-radical resection group. To minimized the selection bias and mixed bias in the comparison, propensity score matching (PSM) and multivariate regression analysis were carried out. In the entire cohort, 120 patients underwent radical surgery and 757 patients received non-radical resection. The 1, 3, and 5-year OS rates were 95.7%, 80.2%, and 69.6% in the radical resection group versus 94.3%, 86.8%, and 77.2% in the non-radical resection group, respectively. (p=0.069) Meanwhile, radical resection had the similar CSS rates of 1, 3 and 5-year compared with non-radical surgery. (1-year CSS rate: 97.4% vs. 98.0%, 3-year CSS rate: 86.1% vs. 93.2%, 5-year CSS rate: 81.6% vs. 88.3%; p =0.056) Besides, after adjusting for other clinical factors and PSM, the long-term OS and CSS did not significantly differ between radical surgery and non-radical surgery. Our study preliminarily found that for small intestinal GISTs, there was no significant difference in long-term survival between radical surgery and non-radical surgery.

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