Can Cystatin C Replace Creatinine to Estimate Glomerular Filtration Rate? A Literature Review

2007 ◽  
Vol 27 (2) ◽  
pp. 197-205 ◽  
Author(s):  
Ahmed Zahran ◽  
Amr El-Husseini ◽  
Ahmed Shoker
Keyword(s):  
Glomerular Filtration Rate ◽  
Literature Review ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Estimate Glomerular Filtration Rate

scholarly journals Performance of creatinine- or cystatin C–based equations to estimate glomerular filtration rate in sub-Saharan African populations

2019 ◽  
Vol 95 (5) ◽  
pp. 1181-1189 ◽  
Author(s):  
Justine B. Bukabau ◽  
Eric Yayo ◽  
Appolinaire Gnionsahé ◽  
Dagui Monnet ◽  
Hans Pottel ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
African Populations ◽  
Estimate Glomerular Filtration Rate ◽  
Sub Saharan

Evaluation of methods based on creatinine and cystatin C to estimate glomerular filtration rate in chronic kidney disease

2013 ◽  
Vol 46 (6) ◽  
pp. 1161-1167 ◽  
Author(s):  
Almudena Vega ◽  
Soledad García de Vinuesa ◽  
Marian Goicoechea ◽  
Úrsula Verdalles ◽  
María Luz Martínez-Pueyo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Estimate Glomerular Filtration Rate ◽  
Evaluation Of Methods

CREATININE VERSUS CYSTATIN C TO ESTIMATE GLOMERULAR FILTRATION RATE IN ADULTS WITH CONGENITAL HEART DISEASE

2019 ◽  
Vol 73 (9) ◽  
pp. 565
Author(s):  
Saurabh Rajpal ◽  
Matthew Carazo ◽  
Michael Singh ◽  
Konstantinos Dimopoulos ◽  
David Alejandro Cardona Estrada ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Congenital Heart ◽  
Filtration Rate ◽  
Estimate Glomerular Filtration Rate

Cystatin C-Creatinine Based Glomerular Filtration Rate Equation in Obese Chronic Kidney Disease Patients: Impact of Deindexation and Gender

2016 ◽  
Vol 44 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Sandrine Lemoine ◽  
Marine Panaye ◽  
Caroline Pelletier ◽  
Chantal Bon ◽  
Laurent Juillard ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Reference Method ◽  
Obese Women ◽  
Estimate Glomerular Filtration Rate ◽  
And Gender

Background: Cystatin C is considered an alternative to creatinine to estimate glomerular filtration rate (GFR). However, studies have reported that increased adiposity is associated with a higher level of circulating cystatin C questioning the performance of estimation of GFR using cystatin C in obese subjects. Methods: We prospectively included 166 obese stages 1-5 chronic kidney disease (CKD) patients between 2013 and 2015. GFR was measured with a reference method without (measured GFR [mGFR]) and with adjustment to body surface area (mGFRr) and estimated (eGFR) or de-indexed eGFR using the Chronic Kidney Disease and Epidemiology (CKD-EPI) equation using creatinine (CKD-EPIcreat), cystatin (CKD-EPIcyst) and the combination of cystatin and creatinine (CKD-EPIcyst-creat). Results: The biases between mGFR and de-indexed CKD-EPIcyst-creat were significantly lower than de-indexed CKD-EPIcreat (p = 0.001). Accuracies were significantly better with de-indexed CKD-EPIcyst-creat compared to CKD-EPIcreat and CKD-EPIcyst, respectively (p = 0.04 and 0.03). Bland and Altman plot showed a great dispersion of all formulae when patients had a GFR >60 ml/min. Interestingly, there is a gender difference; biases, precisions and accuracies of de-indexed CKD-EPIcyst-creat were significantly lower in obese women. These results may be related to a difference in the change of body composition during obesity in men versus women and in fact only waist circumference (WC) was positively and significantly correlated with cystatin C (p < 0.0001) whereas body mass index (BMI; p = 0.3) was not; bias for CKD-EPIcyst-creat was related with WC. Conclusion: Cystatin C-creatinine-based GFR equations outperform creatinine-based formula in obese CKD patients especially those with BMI ≥35 and in obese women.

Analytic and clinical validation of a standardized cystatin C particle enhanced turbidimetric assay (PETIA) to estimate glomerular filtration rate

2012 ◽  
Vol 50 (9) ◽  
Author(s):  
Nikolay V. Voskoboev ◽  
Timothy S. Larson ◽  
Andrew D. Rule ◽  
John C. Lieske
Keyword(s):  
Glomerular Filtration Rate ◽  
Reference Material ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Reference Intervals ◽  
Specific Reference ◽  
Estimate Glomerular Filtration Rate ◽  
Turbidimetric Assay ◽  
And Gender

AbstractCystatin C is an alternative biomarker for assessing glomerular filtration rate (GFR), yet lack of standardization could hinder its widespread use. In this study we analytically and clinically validated a newer cystatin C particle-enhanced turbidimetric assay (PETIA) traceable to a certified reference material and compared it to the more commonly used particle-enhanced nephelometric assay (PENIA).Samples from four patient cohorts at the Mayo Clinic were studied: 1) clinical convenience samples (n=50); 2) samples from patients undergoing iothalamate urinary clearance testing for clinical indications (n=101); 3) volunteers without kidney disease (n=292); 4) samples from 1999–2000 with previous cystatin C measurements.The cystatin C PETIA was analytically robust between 0.15 mg/L and 8.36 mg/L. PETIA cystatin C values were 27.5% higher than PENIA results. Furthermore, PENIA results were 12.9% lower in 2010 than in 2000. PETIA cystatin C values and existing equations performed reasonably well to estimate GFR with an overall –7.4% bias for all patients analyzed. Age and gender specific reference intervals were established for the PETIA cystatin C.Cystatin C can be precisely measured by PETIA traceable to the international reference material, ERM-DA471/IFCC, using a routine chemistry autoanalyzer. There are important biases between this assay and the widely employed Siemens PENIA. This study highlights the importance of assay standardization if cystatin C is to be widely used to estimate GFR.

Sign in / Sign up

Export Citation Format

Share Document