Changes in Bone Microarchitecture and Bone Mineral Density following Experimental Osteonecrosis of the Hip in Rabbits

2006 ◽  
Vol 184 (3-4) ◽  
pp. 138-147 ◽  
Author(s):  
Jochen G. Hofstaetter ◽  
Jinxi Wang ◽  
Jun Yan ◽  
Melvin J. Glimcher
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Mineral Density

scholarly journals DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Endocrine ◽  
2021 ◽  
Author(s):  
Enisa Shevroja ◽  
Francesco Pio Cafarelli ◽  
Giuseppe Guglielmi ◽  
Didier Hans
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Increased Risk

AbstractOsteoporosis, a disease characterized by low bone mass and alterations of bone microarchitecture, leading to an increased risk for fragility fractures and, eventually, to fracture; is associated with an excess of mortality, a decrease in quality of life, and co-morbidities. Bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA), has been the gold standard for the diagnosis of osteoporosis. Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA images, is an index of bone microarchitecture. TBS has been robustly shown to predict fractures independently of BMD. In this review, while reporting also results on BMD, we mainly focus on the TBS role in the assessment of bone health in endocrine disorders known to be reflected in bone.

scholarly journals Bone Mineral Density and Bone Microarchitecture in a Cohort of Patients with Erdheim-Chester Disease

2020 ◽  
Author(s):  
Tianhua He ◽  
Lijia Cui ◽  
Na Niu ◽  
Fengdan Wang ◽  
Huilei Miao ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Erdheim Chester Disease ◽  
Volumetric Bmd ◽  
Normal Mean ◽  
Erdheim Chester ◽  
Chester Disease

Abstract Background: Erdheim-Chester Disease (ECD) is a rare type of non-Langerhans histiocytosis. Skeletal structures are affected in over 95% ECD patients. Due to the lack of proper imaging assessment tools, the alteration of bone microarchitecture in ECD has not been well studied. High-resolution peripheral quantitative computed tomography (HR-pQCT) is a newly developed assessment of bone mineral density and bone microarchitecture.Methods: We performed a cross-sectional study with thirteen patients diagnosed with ECD in Peking Union Medical College Hospital between October 2018 and June 2019. The diagnosis of ECD was based on typical pathological findings in the context of appropriate clinical and radiological manifestations. Bone geometry, volumetric bone mineral density and bone microarchitecture of those ECD patients were assessed using HR-pQCT at the non-dominant distal radius and distal tibia. Those HR-pQCT parameters were then compared to an ongoing population-based database of HR-pQCT for Mainland Chinese.Results: As a result, remarkable heterogeneity of osteosclerosis in HR-pQCT images was found in ECD patients, ranging from apparently normal structure, scattered thickening of trabecula, to homogenous consolidation. On quantitative measurements, total volumetric BMD (383.50mg/cm3, 1.352 times of normal mean, p=0.023) of the tibia differed significantly in ECD patients, attributing to the increased trabecular volumetric BMD (291 mg/cm3, 2.058 times of normal mean, p=0.003). The increased trabecular volumetric BMD of tibia was associated with remarkably increased number of trabecula (1.7/mm, 1.455 times of normal mean, p=0.002) and increased thickness of trabecula (0.37mm, 1.466 times of normal mean, p=0.003). These differences could be due to the existence of dense bone interposed in the trabecula.Conclusion: This study is the first to assess the volumetric bone mineral density and bone microstructure with HR-pQCT in a cohort of ECD patients, and indicated that the application of HR-pQCT may help to reveal the nature of bone lesions in the disease.

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