Novel Single Nucleotide Polymorphisms in the Specific Protein 1 Binding Site of the Bovine PRNP Promoter in Japanese Black Cattle: Impairment of Its Promoter Activity

Intervirology ◽  
2007 ◽  
Vol 50 (3) ◽  
pp. 190-196 ◽  
Author(s):  
Izuru Nakamura ◽  
Guangai Xue ◽  
Akikazu Sakudo ◽  
Keiichi Saeki ◽  
Yoshitsugu Matsumoto ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Binding Site ◽  
Promoter Activity ◽  
Specific Protein ◽  
Nucleotide Polymorphisms ◽  
Japanese Black Cattle ◽  
Single Nucleotide

Multiple marker effects of single nucleotide polymorphisms in three genes,AKIRIN2,EDG1andRPL27A, for marbling development in Japanese Black cattle

2013 ◽  
Vol 85 (3) ◽  
pp. 193-197 ◽  
Author(s):  
Shin Sukegawa ◽  
Takeshi Miyake ◽  
Takayuki Ibi ◽  
Yoichi Takahagi ◽  
Hiroshi Murakami ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Japanese Black Cattle ◽  
Single Nucleotide

Promoter activity of human tissue inhibitor of metalloproteinase 2 gene with novel single nucleotide polymorphisms

Respirology ◽  
2005 ◽  
Vol 10 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Ahmed E. HEGAB ◽  
Tohru SAKAMOTO ◽  
Yoshiyuki UCHIDA ◽  
Akihiro NOMURA ◽  
Yukio ISHII ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Human Tissue ◽  
Promoter Activity ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Nucleotide Polymorphisms ◽  
Tissue Inhibitor ◽  
Single Nucleotide

scholarly journals Association of Polymorphisms with Gastric Cancer: Single Nucleotide Polymorphisms in Promoter or Micro Rna Binding Site?

2014 ◽  
Vol 25 ◽  
pp. iv223
Author(s):  
S. Derakhshani ◽  
S. Baradaran Ghavami ◽  
B. Damavand ◽  
P. Azimzadeh ◽  
S.R. Mohebbi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Single Nucleotide Polymorphisms ◽  
Binding Site ◽  
Rna Binding ◽  
Micro Rna ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Single Nucleotide Polymorphisms Alter the Promoter Activity of Bovine MIF

2011 ◽  
Vol 22 (3) ◽  
pp. 143-150 ◽  
Author(s):  
C. P. Verschoor ◽  
S. D. Pant ◽  
Q. You ◽  
F. S. Schenkel ◽  
D. F. Kelton ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Promoter Activity ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Single-Nucleotide Polymorphisms of the Trypanosoma cruzi MSH2 Gene Support the Existence of Three Phylogenetic Lineages Presenting Differences in Mismatch-Repair Efficiency

Genetics ◽  
2003 ◽  
Vol 164 (1) ◽  
pp. 117-126
Author(s):  
Luiz Augusto-Pinto ◽  
Santuza M R Teixeira ◽  
Sérgio D J Pena ◽  
Carlos Renato Machado
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Trypanosoma Cruzi ◽  
Mismatch Repair ◽  
Rflp Analysis ◽  
Specific Protein ◽  
Mismatch Repair Gene ◽  
Nucleotide Polymorphisms ◽  
Repair Gene ◽  
Single Nucleotide ◽  
Phylogenetic Lineages

Abstract We have identified single-nucleotide polymorphisms (SNPs) in the mismatch-repair gene TcMSH2 from Trypanosoma cruzi. Phylogenetic inferences based on the SNPs, confirmed by RFLP analysis of 32 strains, showed three distinct haplogroups, denominated A, B, and C. Haplogroups A and C presented strong identity with the previously described T. cruzi lineages I and II, respectively. A third haplogroup (B) was composed of strains presenting hybrid characteristics. All strains from a haplogroup encoded the same specific protein isoform, called, respectively, TcMHS2a, TcMHS2b, and TcMHS2c. The classification into haplogroups A, B, and C correlated with variation in the efficiency of mismatch repair in these cells. When microsatellite loci of strains representative of each haplogroup were analyzed after being cultured in the presence of hydrogen peroxide, new microsatellite alleles were definitely seen in haplogroups B and C, while no evidence of microsatellite instability was found in haplogroup A. Also, cells from haplogroups B and C were considerably more resistant to cisplatin treatment, a characteristic known to be conferred by deficiency of mismatch repair in eukaryotic cells. Altogether, our data suggest that strains belonging to haplogroups B and C may have decreased mismatch-repair ability when compared with strains assigned to the haplogroup A lineage.

Sign in / Sign up

Export Citation Format

Share Document