Different Migration of Vascular Smooth Muscle Cells from Human Coronary Artery Bypass Vessels

2007 ◽  
Vol 44 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Sabine Weiss ◽  
Karin Frischknecht ◽  
Helen Greutert ◽  
Sravan Payeli ◽  
Jan Steffel ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Coronary Artery Bypass ◽  
Vascular Smooth Muscle Cells ◽  
Artery Bypass ◽  
Muscle Cells ◽  
Human Coronary Artery

K + Currents in Human Coronary Artery Vascular Smooth Muscle Cells

1996 ◽  
Vol 78 (4) ◽  
pp. 676-688 ◽  
Author(s):  
Maik Gollasch ◽  
Christian Ried ◽  
Rostislav Bychkov ◽  
Friedrich C. Luft ◽  
Hermann Haller
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Human Coronary Artery ◽  
K Currents

The Apoptotic Effect of Angiotensin II in Human Vascular Smooth Muscle Cells

2000 ◽  
Vol 6 (S2) ◽  
pp. 636-637
Author(s):  
E. Ou ◽  
C. Wei
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Receptor Antagonist ◽  
Vascular Smooth Muscle Cells ◽  
Artery Bypass ◽  
Muscle Cells ◽  
Tunel Staining ◽  
Apoptotic Effect

Angiotensin II is a potent vasoconstrictor and mitogenic factor. However, the effects of angiotensin II on human vascular smooth muscle cells apoptosis remain controversial. Therefore, the current study was designed to investigate the actions of angiotensin II on human vascular smooth muscle cells apoptosis.Human saphenous vein was obtained from coronary artery bypass surgery (n=6) and was minced and incubated in the special tissue culture system in the absence or presence of angiotensin II (10-6 to 10-12M) for 1, 2, 4, 8, 16, & 24 hours. These studies were repeated with losartan (10-6M, AT- 1 receptor antagonist) and PD-123319 (10-6M, AT-2 receptor antagonist). To detect the DNA fragmentation, in situ terminal deoxymucleotidyl transferase dUTP nick end labeling (TUNEL) and DNA agarose gel analyses were performed. An average of 1000 nuclei was analyzed for TUNEL studies.TUNEL staining and DNA gel analysis demonstrated that angiotensin II increased apoptosis in human vascular smooth muscle cells.

Mechanics of resting isolated single vascular smooth muscle cells from bovine coronary artery

1984 ◽  
Vol 246 (3) ◽  
pp. C277-C287 ◽  
Author(s):  
A. M. VanDijk ◽  
P. A. Wieringa ◽  
M. van der Meer ◽  
J. D. Laird
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Viscous Resistance ◽  
Resting Cells ◽  
Initial Length ◽  
Arterial Smooth Muscle

The viscoelastic behavior of single resting vascular smooth muscle cells from bovine coronary artery was studied. No maintained passive force could be recorded, even when the cells were stretched to two to four times their initial length; this finding suggests that the smooth muscle cells do not contribute to the parallel elastic component in arterial smooth muscle tissue. The force during stretch of resting arterial cells was proportional to the rate of stretch (which varied between 20 and 60% of the initial length per second). This linear viscous resistance was also found for toad stomach cells when similar stretches were applied. The stress-relaxation curves of the arterial cells could be fitted to the sum of two exponential components (with half-lives of 13.1 and 0.5 s, respectively). As a result of the above findings, a model consisting of two viscoelastic elements in parallel was proposed for a single resting arterial smooth muscle cell. The viscous resistance to stretch of resting cells in a Ca2+-containing solution was not significantly (P greater than 0.01) different from that in a Ca2+-free solution. The same result was obtained for bovine coronary arterial rings. It is concluded that an adequate model for resting arterial smooth muscle should include an intracellular viscous element.

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