Early Low-Dose Hydrocortisone in Very Preterm Infants: A Randomized, Placebo-Controlled Trial

Neonatology ◽  
2006 ◽  
Vol 91 (4) ◽  
pp. 217-221 ◽  
Author(s):  
F. Bonsante ◽  
G. Latorre ◽  
S. Iacobelli ◽  
V. Forziati ◽  
N. Laforgia ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Low Dose ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm

scholarly journals Patent ductus arteriosus, systemic NT-proBNP concentrations and development of bronchopulmonary dysplasia in very preterm infants: retrospective data analysis from a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Solomiia Potsiurko ◽  
Dmytro Dobryanskyy ◽  
Lesya Sekretar
Keyword(s):  
Randomized Controlled Trial ◽  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Roc Curve ◽  
Controlled Trial ◽  
Ductus Arteriosus ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomized Controlled ◽  
Patent Ductus

Abstract Background Patent ductus arteriosus (PDA) is a common complication in very preterm infants. It is known that there is an association between PDA and development of bronchopulmonary dysplasia (BPD) or death before the postmenstrual age (PMA) of 36 weeks, but this association remains one of the most controversial aspects of the problem. The study aimed to evaluate the relationship between PDA, serum NT-proBNP levels at 2–3 and 8–9 days of life, and BPD/death in very preterm infants. Methods Data of 52 preterm infants with a gestational age < 32 weeks, chronological age < 72 h, and PDA diameter > 1.5 mm, enrolled in a randomized controlled trial, were used for the retrospective analysis. All patients underwent daily echocardiographic and two serum NT-proBNP measurements within the first 10 days after birth. Two groups of infants were formed retrospectively at PMA of 36 weeks depending on the outcome, BPD (n = 18)/death (n = 7) or survival without BPD (n = 27). Receiver operator characteristic (ROC) curve was used to evaluate the predictive performance of serum NT-proBNP levels for BPD/death occurrence. Results The percentage of infants who received pharmacological treatment for PDA did not differ between the groups. Based on the area under the ROC curve, serum NT-proBNP levels on the 2–3 day of life (AUC = 0.71; 95% confidence interval (CI): 0.56–0.9; p = 0.014)) and on the 8–9 day of life (AUC = 0.76; 95% CI: 0.6–0.9; p = 0.002) could reliably predict BPD/death in very preterm infants who had PDA diameter > 1.5 mm in the first 72 h of life. Hemodynamically significant PDA (hsPDA) was significantly more often detected in newborns with BPD/death, however, treatment of infants with hsPDA did not reduce the incidence of BPD/death. Conclusions In very preterm infants with PDA > 1.5 mm at the age of 24–48 h, serum NT-proBNP concentration could reliably predict the development of BPD or death, regardless of the persistence of PDA, with the highest diagnostic value at 8–9 days. Trial registration This study is registered in ClinicalTrials.gov - NCT03860428 on March 4, 2019.

scholarly journals Enteral Lactoferrin Supplementation for Very Preterm Infants: A Randomised Controlled Trial

2018 ◽  
Author(s):  
James Griffiths ◽  
Paula Jenkins ◽  
Monika Vargova ◽  
Ursula Bowler ◽  
Edmund Juszczak ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled

Topical Coconut Oil in Very Preterm Infants: An Open-Label Randomised Controlled Trial

Neonatology ◽  
2017 ◽  
Vol 113 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Tobias Strunk ◽  
Sameer Pupala ◽  
Julie Hibbert ◽  
Dorota Doherty ◽  
Sanjay Patole
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Coconut Oil ◽  
Open Label ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled

High Early Parenteral Lipid in Very Preterm Infants: A Randomized-Controlled Trial

2021 ◽  
Vol 228 ◽  
pp. 16-23.e1 ◽  
Author(s):  
Wissam Alburaki ◽  
Kamran Yusuf ◽  
Jenna Dobry ◽  
Rachel Sheinfeld ◽  
Belal Alshaikh
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomized Controlled

scholarly journals PREMM: preterm early massage by the mother: protocol of a randomised controlled trial of massage therapy in very preterm infants

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Melissa M. Lai ◽  
Giulia D’Acunto ◽  
Andrea Guzzetta ◽  
Roslyn N. Boyd ◽  
Stephen E. Rose ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Massage Therapy ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled
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