Dietary Restriction in Aging Nonhuman Primates

Interdisciplinary Topics in Gerontology - Mechanisms of Dietary Restriction in Aging and Disease ◽

10.1159/000096560 ◽

2006 ◽

pp. 137-158 ◽

Cited By ~ 4

Author(s):

Julie A. Mattison ◽

George S. Roth ◽

Mark A. Lane ◽

Donald K. Ingram

Keyword(s):

Dietary Restriction ◽

Nonhuman Primates

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Dietary Restriction in Nonhuman Primates: Progress Report on the NIA Study

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.1992.tb27434.x ◽

1992 ◽

Vol 673 (1 Physiopatholo) ◽

pp. 36-45 ◽

Cited By ~ 49

Author(s):

M. A. LANE ◽

D. K. INGRAM ◽

R. G. CUTLER ◽

J. J. KNAPKA ◽

D. E. BARNARD ◽

...

Keyword(s):

Dietary Restriction ◽

Nonhuman Primates ◽

Progress Report

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Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

Journal of Experimental Medicine ◽

10.1084/jem.20151100 ◽

2016 ◽

Vol 213 (4) ◽

pp. 535-553 ◽

Cited By ~ 46

Author(s):

Duozhuang Tang ◽

Si Tao ◽

Zhiyang Chen ◽

Ievgen Oleksandrovich Koliesnik ◽

Philip Gerald Calmes ◽

...

Keyword(s):

Dietary Restriction ◽

Nonhuman Primates ◽

Adult Onset ◽

B Lymphopoiesis ◽

Laboratory Mice ◽

Negative Effects ◽

Hematopoietic Stem ◽

Beneficial Effects ◽

Tissue Aging

Dietary restriction (DR) improves health, delays tissue aging, and elongates survival in flies and worms. However, studies on laboratory mice and nonhuman primates revealed ambiguous effects of DR on lifespan despite improvements in health parameters. In this study, we analyzed consequences of adult-onset DR (24 h to 1 yr) on hematopoietic stem cell (HSC) function. DR ameliorated HSC aging phenotypes, such as the increase in number of HSCs and the skewing toward myeloid-biased HSCs during aging. Furthermore, DR increased HSC quiescence and improved the maintenance of the repopulation capacity of HSCs during aging. In contrast to these beneficial effects, DR strongly impaired HSC differentiation into lymphoid lineages and particularly inhibited the proliferation of lymphoid progenitors, resulting in decreased production of peripheral B lymphocytes and impaired immune function. The study shows that DR-dependent suppression of growth factors and interleukins mediates these divergent effects caused by DR. Supplementation of insulin-like growth factor 1 partially reverted the DR-induced quiescence of HSCs, whereas IL-6/IL-7 substitutions rescued the impairment of B lymphopoiesis exposed to DR. Together, these findings delineate positive and negative effects of long-term DR on HSC functionality involving distinct stress and growth signaling pathways.

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