Array-based comparative genomic hybridization and copy number variation in cancer research

2006 ◽  
Vol 115 (3-4) ◽  
pp. 262-272 ◽  
Author(s):  
E.K. Cho ◽  
J. Tchinda ◽  
J.L. Freeman ◽  
Y.-J. Chung ◽  
W.W. Cai ◽  
...  
Keyword(s):  
Cancer Research ◽  
Copy Number Variation ◽  
Comparative Genomic Hybridization ◽  
Copy Number ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Number Variation

scholarly journals Measurement of DNA sequence copy number variation using comparative genomic hybridization to microarrays

10.1038/14259 ◽  
1999 ◽  
Vol 23 (S3) ◽  
pp. 30-30
Author(s):  
D.G. Albertson ◽  
R. Segraves ◽  
B. Huey ◽  
X. Zhang ◽  
J. Palmer ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Dna Sequence ◽  
Comparative Genomic Hybridization ◽  
Copy Number ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Number Variation

scholarly journals Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization

2007 ◽  
Vol 8 (10) ◽  
pp. R228 ◽  
Author(s):  
John C Marioni ◽  
Natalie P Thorne ◽  
Armand Valsesia ◽  
Tomas Fitzgerald ◽  
Richard Redon ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Comparative Genomic Hybridization ◽  
Copy Number ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Number Variation ◽  
The Waves

Global patterns of apparent copy number variation in birds revealed by cross-species comparative genomic hybridization

2014 ◽  
Vol 22 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Benjamin M. Skinner ◽  
Abdullah Al Mutery ◽  
Deborah Smith ◽  
Martin Völker ◽  
Nilofour Hojjat ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Comparative Genomic Hybridization ◽  
Copy Number ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Number Variation ◽  
Global Patterns

Comparative Genomic Hybridization to Dna Microarrays

1997 ◽  
Vol 3 (S2) ◽  
pp. 205-206
Author(s):  
D. Pinkel ◽  
R. Segraves ◽  
D. Sudar ◽  
L. van Vliet ◽  
S. Clark ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Copy Number ◽  
Dna Microarrays ◽  
Suppressor Gene ◽  
Comparative Genomic ◽  
Cancer Genes ◽  
Genomic Hybridization ◽  
Metaphase Chromosomes ◽  
Number Variation ◽  
Genetic Events

Comparative genomic hybridization (CGH), which involves the simultaneous hybridization of differentially labeled total genomic DNA from test cells and reference normal cells to metaphase chromosomes, has been used extensively to screen tumor genomes for regions of DNA sequence copy number variation. Analysis of these hybridizations requires quantitative analysis of the ratio of intensities of the fluorescent hybridization signals as a function of position along the chromosomes, which basically serve as a convenient genetic map. The ratios need to be measured very accurately since changes of about ± 20% from the average for the genome indicate important genetic events. Widespread use of CGH over the past several years has identified numerous regions of the genome that may contain currently unknown cancer genes. For example, regions of increased copy number may indicate sites of oncogenes, while regions of copy number decrease relative to average for the genome may signify the presence of a tumor suppressor gene.

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