Plasma Concentrations of Tumor Necrosis Factor Alpha May Predict the Outcome of Patients with Acute Renal Failure

2006 ◽  
Vol 29 (4) ◽  
pp. 203-209 ◽  
Author(s):  
Rafał Ficek ◽  
Franciszek Kokot ◽  
Jerzy Chudek ◽  
Marcin Adamczak ◽  
Joanna Ficek ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Plasma Concentrations ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide

1993 ◽  
Vol 264 (5) ◽  
pp. R1010-R1016 ◽  
Author(s):  
L. E. Morrow ◽  
J. L. McClellan ◽  
C. A. Conn ◽  
M. J. Kluger
Keyword(s):  
Tumor Necrosis Factor ◽  
Open Field ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Adrenal Glands ◽  
Plasma Concentrations ◽  
Necrosis Factor Alpha ◽  
Inhibitory Feedback ◽  
Factor Alpha ◽  
Necrosis Factor

The purpose of this study was to determine whether glucocorticoids exert inhibitory feedback on lipopolysaccharide (LPS)-induced fever, stress-induced fever (exposure to an open field), and plasma concentrations of interleukin-6 (IL-6)-like and tumor necrosis factor-alpha (TNF)-like activity in biotelemetered rats. Injections of LPS (50 micrograms/kg) or exposure to an open field (30 min) led to significantly higher fevers in adrenalectomized (ADX) rats than in sham-ADX rats. To test the hypothesis that higher fevers were specifically the result of an absence of glucocorticoids, the glucocorticoid antagonist RU 38486 (20 mg/kg) was administered orally to rats with intact adrenal glands. The RU 38486-treated rats had higher plasma concentrations of IL-6-like activity and developed significantly higher fevers than did vehicle-treated rats. Rats injected intracerebroventricularly with 10 ng RU 38486 also developed higher fevers. Other ADX animals were implanted subcutaneously with replacement corticosterone pellets before exposure to an open field or injection with LPS. In response to an open field or injection with LPS, ADX animals implanted with replacement pellets that mimic plasma concentrations of corticosterone observed in stressed animals (100-mg pellets) developed fevers that were significantly lower than those observed in ADX rats given placebo pellets, but that were not different from fevers in sham-ADX rats given placebo pellets. ADX animals implanted with replacement pellets that mimic plasma concentrations of corticosterone observed in unstressed animals (25-mg pellets) developed fevers that were significantly higher than those observed in sham-ADX rats given placebo pellets, but that were not different from fevers in ADX rats given placebo pellets.(ABSTRACT TRUNCATED AT 250 WORDS)

Perioperative plasma concentrations of tumor necrosis factor-alpha and interleukin-6 in infected patients

1996 ◽  
Vol 24 (3) ◽  
pp. 423-428 ◽  
Author(s):  
Gau-Jun Tang ◽  
Cheng-Deng Kuo ◽  
Tzu-Chen Yen ◽  
H. Sung Kuo ◽  
Kwok-Hon Chan ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Plasma Concentrations ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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