Could Platelet Aggregation Ratio Be an Indicator for Differential Diagnosis of Transient Ischemic Attack and Cerebral Ischemic Stroke?

2006 ◽  
Vol 22 (5-6) ◽  
pp. 372-377
Author(s):  
Mehmet Tatli ◽  
Aslan Guzel ◽  
Aytekin Akyuz ◽  
Sabri Batun
Keyword(s):  
Differential Diagnosis ◽  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Transient Ischemic Attack ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic ◽  
Ischemic Attack ◽  
Aggregation Ratio ◽  
Platelet Aggregation Ratio

scholarly journals Does a shift from ticlopidine to clopidogrel affect platelet aggregation in patients with transient ischemic attack and ischemic stroke?: A multi-center prospective study

Nosotchu ◽  
2009 ◽  
Vol 31 (3) ◽  
pp. 185-187
Author(s):  
Satoshi Kuroda ◽  
Takeo Abumiya ◽  
Hiroshi Yasuda ◽  
Masaaki Hokari ◽  
Katsuhiko Maruichi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Platelet Aggregation ◽  
Prospective Study ◽  
Transient Ischemic Attack ◽  
Ischemic Attack

Irisin Ameliorates Hypoxia/Reoxygenation-Induced Inflammation and Apoptosis in PC12 Cells by Inhibiting TLR4/MYD88 Signaling Pathway

2019 ◽  
Vol 17 (3) ◽  
pp. 329-336
Author(s):  
Wang Jinli ◽  
Xu Fenfen ◽  
Zheng Yuan ◽  
Cheng Xu ◽  
Zhang Piaopiao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Signaling Pathway ◽  
Pc12 Cells ◽  
Major Complication ◽  
Lactic Dehydrogenase ◽  
Dependent Manner ◽  
Cerebral Ischemic Stroke ◽  
Cerebral Ischemic ◽  
Myd88 Signaling ◽  
Hypoxia Reoxygenation

Cardiovascular disease including cerebral ischemic stroke is the major complication that increases the morbidity and mortality in patients with diabetes mellitus as much as four times. It has been well established that irisin, with its ability to regulate glucose and lipid homeostasis as well as anti-inflammatory and anti-apoptotic properties, has been widely examined for its therapeutic potentials in managing metabolic disorders. However, the mechanism of irisin in the regulation of cerebral ischemic stroke remains unclear. Using PC12 cells as a model, we have shown that hypoxia/reoxygenation inhibits cell viability and increases lactic dehydrogenase. Irisin, in a dose-dependent manner, reversed these changes. The increase in inflammatory mediators (IL-1β, IL-6, and TNF-α) by hypoxia/reoxygenation was reversed by irisin. Furthermore, the cell apoptosis promoted by hypoxia/reoxygenation was also inhibited by irisin. Irisin suppressed TLR4/MyD88 signaling pathway leading to amelioration of inflammation and apoptosis in PC12 cells. Thus, inhibition of TLR4/MyD88 signaling pathway via irisin could be an important mechanism in the regulation of hypoxia/reoxygenation-induced inflammation and apoptosis in PC12 cells.

Risk factor control after ischemic stroke or transient ischemic attack

2021 ◽  
Author(s):  
Nanxiang Ouyang ◽  
Chuning Shi ◽  
Xiaofan Guo ◽  
Yihan Chen ◽  
Yingxian Sun
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Transient Ischemic Attack ◽  
Risk Factor Control ◽  
Ischemic Attack
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