Prevalence of Ineffective Esophageal Motility and Its Relevance to Symptoms and Esophageal Acid Exposure in Korean Patients Referred for Foregut Symptoms

Digestion ◽  
2006 ◽  
Vol 73 (2-3) ◽  
pp. 171-177 ◽  
Author(s):  
Kwang Jae Lee ◽  
Jin Hong Kim ◽  
Sung Won Cho
Keyword(s):  
Esophageal Motility ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Ineffective Esophageal Motility ◽  
Korean Patients

Ineffective esophageal motility and esophageal acid exposure

2001 ◽  
Vol 120 (5) ◽  
pp. A429-A429
Author(s):  
M FEIN ◽  
K FUCHS ◽  
G VARGA ◽  
S FREYS ◽  
J MAROSKE ◽  
...  
Keyword(s):  
Esophageal Motility ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Ineffective Esophageal Motility

Ineffective esophageal motility and esophageal acid exposure

2001 ◽  
Vol 120 (5) ◽  
pp. A429
Author(s):  
Martin Fein ◽  
Karl-Herrmann Fuchs ◽  
Gabor Varga ◽  
Stephan M. Freys ◽  
Joern Maroske ◽  
...  
Keyword(s):  
Esophageal Motility ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Ineffective Esophageal Motility

Phenotyping patients with borderline elevated esophageal acid exposure

2021 ◽  
Author(s):  
Chanakyaram A Reddy ◽  
Kevin Wenzke ◽  
Lydia S Watts ◽  
Moira Armstrong ◽  
Vincent L Chen ◽  
...  
Keyword(s):  
Esophageal Motility ◽  
Clinical Information ◽  
Acid Reflux ◽  
Acid Exposure ◽  
Esophageal Motility Disorder ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility ◽  
Impedance Testing ◽  
Group A ◽  
Acid Exposure Time

Summary Acid exposure time (AET) <4% on ambulatory reflux monitoring definitively rules out pathologic gastroesophageal acid reflux, while AET >6% indicates pathologic reflux per the Lyon Consensus, leaving AET of 4–6% as borderline. We aimed to elucidate the borderline AET population and identify metrics that could help differentiate this group. A total of 50 subjects in each group, AET <4, 4–6, and >6% on pH-impedance monitoring between 2015 and 2019, were retrospectively reviewed. In addition to demographic and clinical information, the extracted data included mean nocturnal baseline impedance (MNBI) on reflux study and high-resolution manometry (HRM) parameters and diagnosis. After excluding patients with prior foregut surgery, major esophageal motility disorder, or unreliable impedance testing, a total of 89 subjects were included in the analysis (25 with normal AET < 4%, 38 with borderline 4–6%, 26 with abnormal >6%). MNBI in borderline AET patients was significantly lower compared to normal AET (1607.7 vs. 2524.0 ohms, P < 0.01), and higher than abnormal AET (951.5 ohms, P < 0.01). Borderline subjects had a greater frequency of ineffective esophageal motility (IEM) diagnosis per Chicago classification v3.0 (42.1 vs. 8.0%, P = 0.01), but did not demonstrate any differences compared to abnormal subjects (34.6%, P = 0.56). Patients with borderline AET had an average MNBI that was in between normal AET and abnormal AET. Borderline AET patients also commonly demonstrate IEM on HRM, similar to those with abnormal AET. Our findings can be potentially useful in assigning higher clinical significance for patients found to have borderline AET with concomitant low MNBI and IEM on manometry.

scholarly journals Effect of electrical stimulation therapy of the lower esophageal sphincter in GERD patients with ineffective esophageal motility

2020 ◽  
Author(s):  
Matthias Paireder ◽  
Ivan Kristo ◽  
Reza Asari ◽  
Gerd Jomrich ◽  
Johannes Steindl ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Esophageal Acid Exposure ◽  
Acid Exposure ◽  
Health Related Quality ◽  
Electrical Stimulation Therapy ◽  
Ineffective Esophageal Motility ◽  
Related Quality ◽  
Health Related ◽  
Esophageal Sphincter

Abstract Background Electrical stimulation therapy (EST) of the lower esophageal sphincter (LES) is a novel technique in antireflux surgery. Due to the minimal alteration at the LES during surgery, LES-EST is meant to be ideal for patients with gastroesophageal reflux disease (GERD) and ineffective esophageal motility (IEM). The aim of this prospective trial (NCT03476265) is to evaluate health-related quality of life and esophageal acid exposure after LES-EST in patients with GERD and IEM. Methods This is a prospective non-randomized open-label study. Patients with GERD and IEM undergoing LES-EST were included. Follow-up (FUP) at 12 months after surgery included health-related quality of life (HRQL) assessment with standardized questionnaires (GERD-HRQL) and esophageal functional testing. Results According to the study protocol, 17 patients fulfilled eligibility criteria. HRQL score for heartburn and regurgitation improved from 21 (interquartile range (IQR) 15–27) to 7.5 (1.25–19), p = 0.001 and from 17 (11–23.5) to 4 (0–12), p = 0.003, respectively. There was neither significant improvement of esophageal acid exposure nor reduction of number of reflux events in pH impedance measurement. Distal contractile integral improved from 64 (11.5–301) to 115 (IQR 10–363) mmHg s cm, p = 0.249. None of the patients showed any sign of dysphagia after LES-EST. One patient needed re-do surgery and re-implantation of the LES-EST due to breaking of the lead after one year. Conclusion Although patient satisfaction improved significantly after surgery, this study fails to demonstrate normalization or significant improvement of acid exposure in the distal esophagus after LES-EST.

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