Double-Blind Study of OM-85 in Patients with Chronic Bronchitis or Mild Chronic Obstructive Pulmonary Disease

Respiration ◽  
2006 ◽  
Vol 74 (1) ◽  
pp. 26-32 ◽  
Author(s):  
M. Solèr ◽  
R. Mütterlein ◽  
G. Cozma
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Chronic Bronchitis ◽  
Pulmonary Disease ◽  
Blind Study ◽  
Chronic Obstructive ◽  
Double Blind Study ◽  
Double Blind ◽  
Obstructive Pulmonary Disease

scholarly journals Plant-based formulation in the management of chronic obstructive pulmonary disease: A randomized double-blind study

2006 ◽  
Vol 100 (1) ◽  
pp. 39-45 ◽  
Author(s):  
P.M. Murali ◽  
S. Rajasekaran ◽  
P. Paramesh ◽  
O.R. Krishnarajasekar ◽  
S. Vasudevan ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Blind Study ◽  
Chronic Obstructive ◽  
Double Blind Study ◽  
Double Blind ◽  
Obstructive Pulmonary Disease

scholarly journals The effect of a multispecies probiotic on the composition of the faecal microbiota and bowel habits in chronic obstructive pulmonary disease patients treated with antibiotics

2009 ◽  
Vol 103 (10) ◽  
pp. 1452-1460 ◽  
Author(s):  
Catherina J. M. Koning ◽  
Daisy Jonkers ◽  
Hauke Smidt ◽  
Frans Rombouts ◽  
Herman-Jan Pennings ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Antibiotic Treatment ◽  
Denaturing Gradient Gel Electrophoresis ◽  
Chronic Obstructive ◽  
Double Blind Study ◽  
Faecal Microbiota ◽  
Double Blind ◽  
Obstructive Pulmonary Disease ◽  
Bowel Movements

Short-term antibiotic treatment profoundly affects the intestinal microbiota, which may lead to sustained changes in microbiota composition. Probiotics may restore such a disturbance. The objective of the present study was to investigate the effect of a multispecies probiotic on the faecal microbiota during and after antibiotic intake in patients with a history of frequent antibiotic use. In this randomised, placebo-controlled, double-blind study, thirty chronic obstructive pulmonary disease (COPD) patients treated with antibiotics for a respiratory tract infection received 5 g of a multispecies probiotic or placebo twice daily for 2 weeks. Faecal samples were collected at 0, 7, 14 and 63 d. Changes in the composition of the dominant faecal microbiota were determined by PCR-denaturing gradient gel electrophoresis (DGGE). Changes in bacterial subgroups were determined by quantitative PCR and culture. Bowel movements were scored daily according to the Bristol stool form scale. During and after antibiotic treatment, DGGE-based similarity indices (SI) were high ( ≥ 84 %) and band richness was relatively low, both remaining stable over time. No difference in SI was observed between patients with and without diarrhoea-like bowel movements. The multispecies probiotic had a modest effect on the bacterial subgroups. Nevertheless, it affected neither the composition of the dominant faecal microbiota nor the occurrence of diarrhoea-like bowel movements. The dominant faecal microbiota was not affected by antibiotics in this COPD population, suggesting an existing imbalance of the microbiota, which may also have contributed to the lack of effect by probiotic intake.

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