Anti-Inflammatory Activity of Thymol: Inhibitory Effect on the Release of Human Neutrophil Elastase

Pharmacology ◽  
2006 ◽  
Vol 77 (3) ◽  
pp. 130-136 ◽  
Author(s):  
Pier Carlo Braga ◽  
Monica Dal Sasso ◽  
Maria Culici ◽  
Tiziana Bianchi ◽  
Luca Bordoni ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Inhibitory Effect ◽  
Inflammatory Activity ◽  
Human Neutrophil Elastase ◽  
Anti Inflammatory

Screening for Anti-Inflammatory Activity of 12Arnica(Asteraceae) Species Assessed by Inhibition of NF-κB and Release of Human Neutrophil Elastase

Planta Medica ◽  
2008 ◽  
Vol 74 (15) ◽  
pp. 1789-1794 ◽  
Author(s):  
Catarina Ekenäs ◽  
Anna Zebrowska ◽  
Barbara Schuler ◽  
Tobias Vrede ◽  
Katarina Andreasen ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Inflammatory Activity ◽  
Human Neutrophil Elastase ◽  
Anti Inflammatory

Further Sesquiterpene Lactones from Viguiera robusta and the Potential Anti-Inflammatory Activity of a Heliangolide: Inhibition of Human Neutrophil Elastase Release

2008 ◽  
Vol 63 (7-8) ◽  
pp. 533-538 ◽  
Author(s):  
Nilton S. Arakawa ◽  
Karin Schorr ◽  
Sérgio R. Ambrósio ◽  
Irmgard Merfort ◽  
Fernando B. Da Costa
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Sesquiterpene Lactones ◽  
Human Neutrophil Elastase ◽  
Reference Drug ◽  
Aggregation Factor ◽  
Anti Inflammatory ◽  
Isolated Compound

In addition to known heliangolides, a new eudesmanolide was isolated from the leaf rinse extract of Viguiera robusta (Asteraceae). Structural elucidation was based on spectral analysis. It is the first report on eudesmanolides in members of the subgenus Calanticaria of Viguiera. In this work, the main isolated compound, the furanoheliangolide budlein A, besides its previously reported in vitro and in vivo anti-inflammatory activities, inhibited human neutrophil elastase release. The inhibition was at the concentration of (16.83± 1.96) μm for formylated bacterial tripeptide (fMLP) stimulation and (11.84±1.62) μm for platelet aggregation factor (PAF) stimulation, being slightly less active than the reference drug parthenolide. The results are important to demonstrate the potential anti-inflammatory activities of sesquiterpene lactones and corroborate the previous studies using other targets.

scholarly journals Iridal-Type Triterpenoids Displaying Human Neutrophil Elastase Inhibition and Anti-Inflammatory Effects from Belamcanda chinensis

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6602
Author(s):  
Jeong Ho Kim ◽  
Yeong Jun Ban ◽  
Aizhamal Baiseitova ◽  
Marie Merci Nyiramana ◽  
Sang Soo Kang ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Tnf Α ◽  
Belamcanda Chinensis ◽  
Ic50 Values ◽  
Anti Inflammatory ◽  
Noesy Spectra ◽  
Raw264.7 Macrophage ◽  
Noncompetitive Inhibitors

The aim of this study is to explore anti-inflammatory phytochemicals from B. chinensis based on the inhibition of pro-inflammatory enzyme, human neutrophil elastase (HNE) and anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage. Three stereoisomers of iridal-type triterpenoids (1–3) were isolated from the roots of B. chinensis and their stereochemistries were completely identified by NOESY spectra. These compounds were confirmed as reversible noncompetitive inhibitors against HNE with IC50 values of 6.8–27.0 µM. The binding affinity experiment proved that iridal-type triterpenoids had only a single binding site to the HNE enzyme. Among them, isoiridogermanal (1) and iridobelamal A (2) displayed significant anti-inflammatory effects by suppressing the expressions of pro-inflammatory cytokines, such as iNOS, IL-1β, and TNF-α through the NF-κB pathway in LPS-stimulated RAW264.7 cells. This is the first report that iridal-type triterpenoids are considered responsible phytochemicals for anti-inflammatory effects of B. chinensis.

EPI-hNE4, a Proteolysis-Resistant Inhibitor of Human Neutrophil Elastase and Potential Anti-Inflammatory Drug for Treating Cystic Fibrosis

2006 ◽  
Vol 318 (2) ◽  
pp. 803-809 ◽  
Author(s):  
Sylvie Attucci ◽  
Alexandre Gauthier ◽  
Brice Korkmaz ◽  
Pascal Delépine ◽  
Michèle Ferrer-Di Martino ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa

2010 ◽  
Vol 20 (2) ◽  
pp. 513-515 ◽  
Author(s):  
Guang-Hua Xu ◽  
Young-Hee Kim ◽  
Seung-Wook Chi ◽  
Soo-Jin Choo ◽  
In-Ja Ryoo ◽  
...  
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Iridoid Glycosides ◽  
Inhibitory Effect ◽  
Human Neutrophil Elastase ◽  
Hedyotis Diffusa

scholarly journals Anti-inflammatory effects of DX-890, a human neutrophil elastase inhibitor

2012 ◽  
Vol 11 (4) ◽  
pp. 300-304 ◽  
Author(s):  
Fiona K. Dunlevy ◽  
S. Lorraine Martin ◽  
Francine de Courcey ◽  
J. Stuart Elborn ◽  
Madeleine Ennis
Keyword(s):  
Neutrophil Elastase ◽  
Human Neutrophil ◽  
Human Neutrophil Elastase ◽  
Neutrophil Elastase Inhibitor ◽  
Elastase Inhibitor ◽  
Anti Inflammatory
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