Effects of Chymase on the Macular Region in Monkeys and Porcine Müller Cells: Probable Involvement of Chymase in the Onset of Idiopathic Macular Holes

2006 ◽  
Vol 38 (4) ◽  
pp. 201-208 ◽  
Author(s):  
Tetsuya Sugiyama ◽  
Kozo Katsumura ◽  
Kimitoshi Nakamura ◽  
Masato Kobayashi ◽  
Michiko Muramatsu ◽  
...  
Keyword(s):  
Müller Cells ◽  
Muller Cells ◽  
Macular Holes ◽  
Idiopathic Macular Holes

scholarly journals ERG assessment of the functional activity of the retina in following the surgical closure of idiopathic macular holes

2013 ◽  
Vol 6 (4) ◽  
pp. 21-27 ◽  
Author(s):  
Vladimir Vladimirovich Neroev ◽  
Marina Vladimirovna Zueva ◽  
Pavel Alexandrovich Bichkov ◽  
Irina Vladimirovna Tsapenko ◽  
Ol'ga Ivanovna Sarygina ◽  
...  
Keyword(s):  
Recovery Period ◽  
Müller Cells ◽  
Bipolar Cells ◽  
Muller Cells ◽  
Cone Photoreceptors ◽  
Surgical Closure ◽  
Functional Relationships ◽  
Macular Holes ◽  
Flicker Erg ◽  
Idiopathic Macular Holes

Twenty patients with stage 3 or 4 idiopathic macular holes were evaluated with standard cone ERG, photopic flicker ERG at 8,3-30-Hz, to study the function of cone photoreceptors, bipolar cells, and Muller cells after the surgical correction of their macular hole. The correlations between the ERG parameters and the microperimetry and optical coherent tomography data were evaluated. IMH has been associated with the general reduction in the function of the cone photoreceptors and bipolar cells and with the sharp increase in the activity of Muller cells and their functional relationships with some bipolar cells. The nature of the changes in photopic standard and flicker ERGs demonstrated the dependence of the central retinal function on the dynamics of cone bipolar cells’ recovery. In the early period after the surgery of IMH, a sharp reduction in the flicker ERG at 24 Hz was found, to be followed by a progressive increase, which indicated a pronounced reduction in the bipolar cell function with the formation of the IMH and its substantial decrease after the vitreoretinal surgery. A significant increase in the glial index for flicker ERG at 24 Hz may be associated with a compensatory overreaction of retinal Muller cells in the preoperative and in the recovery period after the closure of IMH.

scholarly journals Spontaneous closure of small full‐thickness macular holes: Presumed role of Müller cells

2019 ◽  
Vol 98 (4) ◽  
Author(s):  
Andreas Bringmann ◽  
Tobias Duncker ◽  
Claudia Jochmann ◽  
Thomas Barth ◽  
Gernot I. W. Duncker ◽  
...  
Keyword(s):  
Müller Cells ◽  
Spontaneous Closure ◽  
Muller Cells ◽  
Full Thickness ◽  
Macular Holes

Functional activity of retinal neurons and Muller cells in idiopathic full-thickness macular holes

2012 ◽  
Vol 90 ◽  
pp. 0-0
Author(s):  
M ZUEVA ◽  
V NEROEV ◽  
I TSAPENKO ◽  
P BYCHKOV ◽  
O SARYGINA
Keyword(s):  
Functional Activity ◽  
Müller Cells ◽  
Muller Cells ◽  
Full Thickness ◽  
Retinal Neurons ◽  
Macular Holes

scholarly journals The role of Müller cells in tractional macular disorders: an optical coherence tomography study and physical model of mechanical force transmission

2019 ◽  
Vol 104 (4) ◽  
pp. 466-472 ◽  
Author(s):  
Andrea Govetto ◽  
Jean-Pierre Hubschman ◽  
David Sarraf ◽  
Marta S Figueroa ◽  
Ferdinando Bottoni ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Optical Coherence Tomography ◽  
Müller Cells ◽  
Mechanical Force ◽  
Optical Coherence ◽  
Muller Cells ◽  
Force Transmission ◽  
Myopic Foveoschisis ◽  
Macular Holes

BackgroundTo explore the role of foveal and parafoveal Müller cells in the morphology and pathophysiology of tractional macular disorders with a mathematical model of mechanical force transmission.MethodsIn this retrospective observational study, spectral-domain optical coherence tomography images of tractional lamellar macular holes and patients with myopic foveoschisis were reviewed and analysed with a mathematical model of force transmission. Parafoveal z-shaped Müller cells were modelled as a structure composed of three rigid rods, named R1, R2 and R3. The angle formed between the rods was referred to as θ . R1, R2 and R3 lengths as well as the variation of the angle θ were measured and correlated with best corrected visual acuity (BCVA).ResultsIn tractional lamellar macular holes, there was a significant reduction of the angle θ towards the foveal centre (p<0.001). By contrast, there were no significant differences in θ in myopic foveoschisis (p=0.570). R2 segments were more vertical in myopic foveoschisis. There was a significant association between lower θ angles at 200 µm temporal and nasal to the fovea and lower BCVA (p<0.001 and p=0.005, respectively). The stiffness of parafoveal Müller cells was predicted to be function of the angle θ , and it grew very rapidly as the θ decreased.ConclusionParafoveal Müller cells in the Henle fibre layer may guarantee structural stability of the parafovea by increasing retinal compliance and resistance to mechanical stress. Small values of the angle θ were related to worse BCVA possibly due to damage to Müller cell processes and photoreceptor’s axons.

K+ Channels of Müller Glial Cells in Retinal Disorders

2018 ◽  
Vol 17 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Feng Gao ◽  
Lin-Jie Xu ◽  
Yuan Zhao ◽  
Xing-Huai Sun ◽  
Zhongfeng Wang
Keyword(s):  
Müller Cells ◽  
Major Type ◽  
Delayed Rectifier ◽  
Muller Cells ◽  
Bkca Channels ◽  
K Channels ◽  
Functional Changes ◽  
Physiological Properties ◽  
Retinal Disorders ◽  
Inwardly Rectifying

Background & Objective: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis. Conclusion: In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders.

scholarly journals Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway

2021 ◽  
Vol 137 ◽  
pp. 111274
Author(s):  
Yuanyuan Tu ◽  
E Song ◽  
Zhenzhen Wang ◽  
Na Ji ◽  
Linling Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Müller Cells ◽  
Muller Cells

Vitreous from idiopathic epiretinal membrane patients induces glial-to-mesenchymal transition in Müller cells

2021 ◽  
pp. 166181
Author(s):  
Adwaid Manu Krishna Chandran ◽  
Daniela Coltrini ◽  
Mirella Belleri ◽  
Sara Rezzola ◽  
Elena Gambicorti ◽  
...  
Keyword(s):  
Epiretinal Membrane ◽  
Müller Cells ◽  
Muller Cells ◽  
Mesenchymal Transition ◽  
Idiopathic Epiretinal Membrane

scholarly journals Muller cells are living optical fibers in the vertebrate retina

2007 ◽  
Vol 104 (20) ◽  
pp. 8287-8292 ◽  
Author(s):  
K. Franze ◽  
J. Grosche ◽  
S. N. Skatchkov ◽  
S. Schinkinger ◽  
C. Foja ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Müller Cells ◽  
Muller Cells ◽  
Vertebrate Retina
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