scholarly journals Varicella-Associated Purpura Fulminans: Chicken Pox Is Not Always Benign

2006 ◽  
Vol 15 (3) ◽  
pp. 232-234 ◽  
Author(s):  
A. Abdulmalik ◽  
W. Al-Ateeqi ◽  
M. Al-Khawari ◽  
S. Al-Osaimi
Keyword(s):  
Purpura Fulminans ◽  
Chicken Pox

scholarly journals A rare case of varicella gangrenosum in adult

2020 ◽  
Vol 7 (2) ◽  
pp. 599
Author(s):  
M. Sabari Girieasen ◽  
Naveenkumar Viswanathan ◽  
M/ S. Kalyankumar
Keyword(s):  
Soft Tissues ◽  
Rare Complication ◽  
Purpura Fulminans ◽  
The Body ◽  
Surgical Debridement ◽  
Chicken Pox ◽  
Serous Discharge ◽  
Threatening Condition ◽  
Life Threatening ◽  
Split Skin

Varicella gangrenosum is a gangrenous ulceration of varicella lesions involving the skin and soft tissues of the body. It most commonly occurs in children less than 5 years of age and life threatening. This is a very rare complication of chicken pox in adults which deserves early diagnosis and management. 21-year-old male presented with blackish discoloration in the lateral aspect of right thigh for 5 days. He has positive history of chicken pox for his brother and sister following which he acquired it 15 days back. During that episode he had fever, headache and blisters which ruptured to heal by scab. But scab in right thigh coalesced to form the gangrenous area with serous discharge. On presentation he had no fever with local lesion and surrounding erythema. Patient underwent radical surgical debridement and regular dressing. Pus culture was sent which showed no growth. He gradually improved and the ulcer granulated well and split skin graft is done. Varicella gangrenosum is a life-threatening condition which can be either wet, moist or purpura fulminans. Patients who develop disseminated intravascular coagulation and have a grave prognosis. Surgical debridement is the only proven treatment which has led to better outcome. Only about 10 cases reported in literature so far regarding this condition. 

Purpura Fulminans in a Patient Homozygous for a Mutation in the Protein C Gene - Prenatal Diagnosis in a Subsequent Pregnancy

1996 ◽  
Vol 75 (03) ◽  
pp. 525-526 ◽  
Author(s):  
M C Alessi ◽  
M F Aillaud ◽  
O Paut ◽  
B Roquelaure ◽  
M Alhenc-Gelas ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Protein C ◽  
Purpura Fulminans ◽  
Subsequent Pregnancy

Severe Homozygous Protein C Deficiency: Identification of a Splice Site Missense Mutation (184, Q → H) in Exon 7 of the Protein C Gene

1994 ◽  
Vol 72 (01) ◽  
pp. 065-069 ◽  
Author(s):  
J M Soria ◽  
D Brito ◽  
J Barceló ◽  
J Fontcuberta ◽  
L Botero ◽  
...  
Keyword(s):  
Missense Mutation ◽  
Gene Product ◽  
Splice Site ◽  
Protein C ◽  
Purpura Fulminans ◽  
Single Strand Conformation Polymorphism ◽  
Donor Splice Site ◽  
Protein C Deficiency ◽  
Donor Splice ◽  
Newborn Child

SummarySingle strand conformation polymorphism (SSCP) analysis of exon 7 of the protein C gene has identified a novel splice site missense mutation (184, Q → H), in a newborn child with purpura fulminans and undetectable protein C levels. The mutation, seen in the homozygous state in the child and in the heterozygous state in her mother, was characterized and found to be a G to C nucleotide substitution at the -1 position of the donor splice site of intron 7 of the protein C gene, which changes histidine 184 for glutamine (184, Q → H). According to analysis of the normal and mutated sequences, this mutation should also abolish the function of the donor splice site of intron 7 of the protein C gene. Since such a mutation is compatible with the absence of gene product in plasma and since DNA sequencing of all protein C gene exons in this patient did not reveal any other mutation, we postulate that mutation 184, Q → H results in the absence of protein C gene product in plasma, which could be the cause of the severe phenotype observed in this patient.

CHICKENPOX AND ITS COMMON COMPLICATIONS

2017 ◽  
pp. 7-14
Author(s):  
Dinh Binh Tran ◽  
Thi Ai Liên Dinh
Keyword(s):  
Infectious Disease ◽  
Radiation Therapy ◽  
Emergency Care ◽  
Benign Disease ◽  
Severe Malnutrition ◽  
Child Transmission ◽  
Chicken Pox ◽  
The Family ◽  
Mother To Child ◽  
Bacterial Superinfection

Chickenpox is an infectious disease caused by the Varicella-Zostervirus (VZV), this is a virus in the family of Herpesviridae. It’s characterized by fever, skin rash and mucocutaneous rash. Chickenpox is widely distributed disease with varying in age, seasons, climate, and resident of people . Mother-to-child transmission of the virus can occur during pregnancy, during delivery and after birth. In people who have had chickenpox, after the cure, a few viruses exist in the nerves sensing the spine in the form of latent, silent. When conditions are favorable (triggers) such as immunodeficiency, stress, radiation therapy, cancer, HIV infection ... the virus reacts, multiplies and spreads, causing inflammation and necrosis of the nerve in shingles (Zona). Chickenpox is a benign disease but it can also cause many complications in severe cases and which is not properly treated. Complications of dermatitis due to bacterial superinfection, the peanut note to pus, when cured can leave scar. In patients with severe malnutrition, nodules may be necrotic. The most severe complication is encephalitis, meningitis that are very dangerous, which can cause dead if delayed to hospital and emergency care is not timely. The disease can spread rapidly in the community, but there are active measures to prevent chicken pox, which is vaccination. Key words: Chickenpox, Varicella-Zostervirus (VZV)

Purpura fulminans skin lesions in a newborn with complete protein C deficiency

1998 ◽  
Vol 132 (3) ◽  
pp. 558 ◽  
Author(s):  
Gideon Paret ◽  
Asher Barzilai ◽  
Zohar Barzilay
Keyword(s):  
Protein C ◽  
Purpura Fulminans ◽  
Skin Lesions ◽  
Protein C Deficiency ◽  
Complete Protein

Purpura fulminans due to protein S deficiency following chickenpox

1992 ◽  
Vol 127 (1) ◽  
pp. 30-32 ◽  
Author(s):  
W.G. PHILLIPS ◽  
J.R. MARSDEN ◽  
F.G. HILL
Keyword(s):  
Purpura Fulminans ◽  
Protein S ◽  
Protein S Deficiency ◽  
S Deficiency
Sign in / Sign up

Export Citation Format

Share Document