Proliferation and Differentiation of Adult Endogenous Neural Stem Cells in Response to Neurodegenerative Process within the Striatum

2006 ◽  
Vol 3 (1-2) ◽  
pp. 12-18 ◽  
Author(s):  
Yvona Mazurová ◽  
Emil Rudolf ◽  
Ivan Látr ◽  
Jan Österreicher
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neurodegenerative Process ◽  
Proliferation And Differentiation ◽  
Endogenous Neural Stem Cells

scholarly journals Acupuncture Induces the Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Traumatic Brain Injury

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Shuting Jiang ◽  
Weihao Chen ◽  
Yimin Zhang ◽  
Yujuan Zhang ◽  
Ailian Chen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Calcium Binding ◽  
Acupuncture Group ◽  
Sprague Dawley ◽  
Neural Repair ◽  
Proliferation And Differentiation ◽  
Endogenous Neural Stem Cells

Purpose. To investigate whether acupuncture induced the proliferation and differentiation of endogenous neural stem cells (NSCs) in a rat model of traumatic brain injury (TBI).Methods. 104 Sprague-Dawley rats were randomly divided into normal, model, and acupuncture groups. Each group was subdivided into three-day (3 d), seven-day (7 d), and fourteen-day (14 d) groups. The rat TBI model was established using Feeney’s freefall epidural impact method. The rats in the acupuncture group were treated at acupoints (Baihui, Shuigou, Fengfu, Yamen, and bilateral Hegu). The normal and model groups did not receive acupuncture. The establishment of the rat TBI model and the therapeutic effect of acupuncture were assessed using neurobehavioral scoring and hematoxylin-eosin staining. The proliferation and differentiation of NSCs in TBI rats were analyzed using immunofluorescence microscopy.Results. The levels of nestin-expressing cells and bromodeoxyuridine/glial fibrillary acidic protein- (BrdU/GFAP-) and BrdU/S100 calcium-binding protein B-positive and BrdU/microtubule-associated protein 2- and BrdU/galactocerebrosidase-positive cells were more significantly increased at various time points in the acupuncture group than in the model group (P<0.01), except for a decreased level of BrdU/GFAP-positive cells at 7 d and 14 d.Conclusion. Acupuncture induced the proliferation and differentiation of NSCs, thereby promoting neural repair in the TBI rats.

scholarly journals Endogenous neural stem cells modulate microglia and protect against demyelination

2021 ◽  
Author(s):  
Béatrice Brousse ◽  
Océane Mercier ◽  
Karine Magalon ◽  
Fabrice Daian ◽  
Pascale Durbec ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Endogenous Neural Stem Cells

Astragalus Flavone Induces Proliferation and Differentiation of Neural Stem Cells in a Cerebral Infarction Model

2021 ◽  
Vol 28 ◽  
Author(s):  
Han Gao ◽  
Ningjing Huang ◽  
Weiwei Wang ◽  
Lingling Zhang ◽  
Li Cai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cerebral Infarction ◽  
Neural Stem Cells ◽  
Proliferation And Differentiation
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