A Possible Role for Iron-Sulfur Cluster N2 in Proton Translocation by the NADH:Ubiquinone Oxidoreductase (Complex I)

2005 ◽  
Vol 10 (2-4) ◽  
pp. 208-222 ◽  
Author(s):  
Dirk Flemming ◽  
Stefan Stolpe ◽  
Daniel Schneider ◽  
Petra Hellwig ◽  
Thorsten Friedrich
Keyword(s):  
Complex I ◽  
Proton Translocation ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur

Iron−Sulfur Cluster N7 of the NADH:Ubiquinone Oxidoreductase (Complex I) Is Essential for Stability but Not Involved in Electron Transfer†

Biochemistry ◽  
2007 ◽  
Vol 46 (22) ◽  
pp. 6588-6596 ◽  
Author(s):  
Thomas Pohl ◽  
Theresa Bauer ◽  
Katerina Dörner ◽  
Stefan Stolpe ◽  
Philipp Sell ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Complex I ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur

scholarly journals Iron-sulfur cluster carrier proteins involved in the assembly of Escherichia coli NADH:ubiquinone oxidoreductase (complex I)

2018 ◽  
Vol 111 (1) ◽  
pp. 31-45 ◽  
Author(s):  
Sabrina Burschel ◽  
Doris Kreuzer Decovic ◽  
Franziska Nuber ◽  
Marie Stiller ◽  
Maud Hofmann ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Complex I ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Carrier Proteins ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur

scholarly journals The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2

FEBS Letters ◽  
2001 ◽  
Vol 505 (3) ◽  
pp. 364-368 ◽  
Author(s):  
Maria Luisa Genova ◽  
Barbara Ventura ◽  
Giovanni Giuliano ◽  
Carla Bovina ◽  
Gabriella Formiggini ◽  
...  
Keyword(s):  
Complex I ◽  
Superoxide Radical ◽  
Mitochondrial Complex I ◽  
Mitochondrial Complex ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur

scholarly journals The Redox-Bohr Group Associated with Iron-Sulfur Cluster N2 of Complex I

2006 ◽  
Vol 281 (32) ◽  
pp. 23013-23017 ◽  
Author(s):  
Klaus Zwicker ◽  
Alexander Galkin ◽  
Stefan Dröse ◽  
Ljuban Grgic ◽  
Stefan Kerscher ◽  
...  
Keyword(s):  
Complex I ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur

scholarly journals Structure of the respiratory MBS complex reveals iron-sulfur cluster catalyzed sulfane sulfur reduction in ancient life

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hongjun Yu ◽  
Dominik K. Haja ◽  
Gerrit J. Schut ◽  
Chang-Hao Wu ◽  
Xing Meng ◽  
...  
Keyword(s):  
Complex I ◽  
Hydrogen Gas ◽  
Proton Pumps ◽  
Amino Acid Residues ◽  
Iron Sulfur Cluster ◽  
Terminal Electron Acceptor ◽  
Sulfur Cluster ◽  
Iron Sulfur ◽  
New Perspective ◽  
A Site

AbstractModern day aerobic respiration in mitochondria involving complex I converts redox energy into chemical energy and likely evolved from a simple anaerobic system now represented by hydrogen gas-evolving hydrogenase (MBH) where protons are the terminal electron acceptor. Here we present the cryo-EM structure of an early ancestor in the evolution of complex I, the elemental sulfur (S0)-reducing reductase MBS. Three highly conserved protein loops linking cytoplasmic and membrane domains enable scalable energy conversion in all three complexes. MBS contains two proton pumps compared to one in MBH and likely conserves twice the energy. The structure also reveals evolutionary adaptations of MBH that enabled S0 reduction by MBS catalyzed by a site-differentiated iron-sulfur cluster without participation of protons or amino acid residues. This is the simplest mechanism proposed for reduction of inorganic or organic disulfides. It is of fundamental significance in the iron and sulfur-rich volcanic environments of early earth and possibly the origin of life. MBS provides a new perspective on the evolution of modern-day respiratory complexes and of catalysis by biological iron-sulfur clusters.

scholarly journals Iron-Sulfur Cluster N2 of theEscherichia coliNADH:Ubiquinone Oxidoreductase (Complex I) Is Located on Subunit NuoB

2003 ◽  
Vol 278 (48) ◽  
pp. 47602-47609 ◽  
Author(s):  
Dirk Flemming ◽  
Angela Schlitt ◽  
Volker Spehr ◽  
Tobias Bischof ◽  
Thorsten Friedrich
Keyword(s):  
Complex I ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur

scholarly journals Iron-Sulfur Cluster N5 Is Coordinated by an HXXXCXXCXXXXXC Motif in the NuoG Subunit ofEscherichia coliNADH:Quinone Oxidoreductase (Complex I)

2008 ◽  
Vol 283 (38) ◽  
pp. 25979-25987 ◽  
Author(s):  
Eiko Nakamaru-Ogiso ◽  
Akemi Matsuno-Yagi ◽  
Shinya Yoshikawa ◽  
Takao Yagi ◽  
Tomoko Ohnishi
Keyword(s):  
Complex I ◽  
Iron Sulfur Cluster ◽  
Sulfur Cluster ◽  
Iron Sulfur
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