The Gut Microbiota and Potential Health Effects of Intervention

2006 ◽  
pp. 81-92
Author(s):  
Bengt Björkstén
Keyword(s):  
Gut Microbiota ◽  
Health Effects ◽  
Potential Health

Whole cereal grains and potential health effects: Involvement of the gut microbiota

2018 ◽  
Vol 103 ◽  
pp. 84-102 ◽  
Author(s):  
Lingxiao Gong ◽  
Wenyan Cao ◽  
Hailin Chi ◽  
Jing Wang ◽  
Huijuan Zhang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Health Effects ◽  
Cereal Grains ◽  
Potential Health

scholarly journals Silicon dioxide nanoparticles induced neurobehavioral impairments by disrupting microbiota–gut–brain axis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jun Diao ◽  
Yinyin Xia ◽  
Xuejun Jiang ◽  
Jingfu Qiu ◽  
Shuqun Cheng ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Health Risk ◽  
Silicon Dioxide ◽  
Spatial Learning And Memory ◽  
Rrna Gene ◽  
Silicon Dioxide Nanoparticles ◽  
Potential Health ◽  
Specific Chemical ◽  
Memory Impairments ◽  
Tissue Integrity

Abstract Background Silicon dioxide nanoparticles (SiO2NPs) are widely used as additive in the food industry with controversial health risk. Gut microbiota is a new and hot topic in the field of nanotoxicity. It also contributes a novel and insightful view to understand the potential health risk of food-grade SiO2NPs in children, who are susceptible to the toxic effects of nanoparticles. Methods In current study, the young mice were orally administrated with vehicle or SiO2NPs solution for 28 days. The effects of SiO2NPs on the gut microbiota were detected by 16S ribosomal RNA (rRNA) gene sequencing, and the neurobehavioral functions were evaluated by open field test and Morris water maze. The level of inflammation, tissue integrity of gut and the classical indicators involved in gut–brain, gut–liver and gut–lung axis were all assessed. Results Our results demonstrated that SiO2NPs significantly caused the spatial learning and memory impairments and locomotor inhibition. Although SiO2NPs did not trigger evident intestinal or neuronal inflammation, they remarkably damaged the tissue integrity. The microbial diversity within the gut was unexpectedly enhanced in SiO2NPs-treated mice, mainly manifested by the increased abundances of Firmicutes and Patescibacteria. Intriguingly, we demonstrated for the first time that the neurobehavioral impairments and brain damages induced by SiO2NPs might be distinctively associated with the disruption of gut–brain axis by specific chemical substances originated from gut, such as Vipr1 and Sstr2. Unapparent changes in liver or lung tissues further suggested the absence of gut–liver axis or gut–lung axis regulation upon oral SiO2NPs exposure. Conclusion This study provides a novel idea that the SiO2NPs induced neurotoxic effects may occur through distinctive gut–brain axis, showing no significant impact on either gut–lung axis or gut–liver axis. These findings raise the exciting prospect that maintenance and coordination of gastrointestinal functions may be critical for protection against the neurotoxicity of infant foodborne SiO2NPs.

scholarly journals Curcumin and Its Potential Impact on Microbiota

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2004
Author(s):  
Marzena Jabczyk ◽  
Justyna Nowak ◽  
Bartosz Hudzik ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Biological Activity ◽  
Gut Microbiota ◽  
Health Effects ◽  
Pharmacokinetic Profile ◽  
Health Impact ◽  
Pharmacological Activities ◽  
Poor Solubility ◽  
Potential Impact ◽  
Bidirectional Interactions

Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact.

Ellagitannins, Gallotannins and their Metabolites- The Contribution to the Anti-Inflammatory Effect of Food Products and Medicinal Plants

2019 ◽  
Vol 25 (37) ◽  
pp. 4946-4967 ◽  
Author(s):  
Anna K. Kiss ◽  
Jakub P. Piwowarski
Keyword(s):  
Immune Response ◽  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Health Effects ◽  
Biological Effects ◽  
Food Products ◽  
Anti Inflammatory ◽  
The Impact

The popularity of food products and medicinal plant materials containing hydrolysable tannins (HT) is nowadays rapidly increasing. Among various health effects attributable to the products of plant origin rich in gallotannins and/or ellagitannins the most often underlined is the beneficial influence on diseases possessing inflammatory background. Results of clinical, interventional and animal in vivo studies clearly indicate the antiinflammatory potential of HT-containing products, as well as pure ellagitannins and gallotannins. In recent years a great emphasis has been put on the consideration of metabolism and bioavailability of natural products during examination of their biological effects. Conducted in vivo and in vitro studies of polyphenols metabolism put a new light on this issue and indicate the gut microbiota to play a crucial role in the health effects following their oral administration. The aim of the review is to summarize the knowledge about HT-containing products’ phytochemistry and their anti-inflammatory effects together with discussion of the data about observed biological activities with regards to the current concepts on the HTs’ bioavailability and metabolism. Orally administered HT-containing products due to the limited bioavailability of ellagitannins and gallotannins can influence immune response at the level of gastrointestinal tract as well as express modulating effects on the gut microbiota composition. However, due to the chemical changes being a result of their transit through gastrointestinal tract, comprising of hydrolysis and gut microbiota metabolism, the activity of produced metabolites has to be taken into consideration. Studies regarding biological effects of the HTs’ metabolites, in particular urolithins, indicate their strong and structure-dependent anti-inflammatory activities, being observed at the concentrations, which fit the range of their established bioavailability. The impact of HTs on inflammatory processes has been well established on various in vivo and in vitro models, while influence of microbiota metabolites on silencing the immune response gives a new perspective on understanding anti-inflammatory effects attributed to HT containing products, especially their postulated effectiveness in inflammatory bowel diseases (IBD) and cardiovascular diseases.

Accumulation and potential health effects of organohalogenated compounds in the arctic fox (Vulpes lagopus)—a review

2015 ◽  
Vol 502 ◽  
pp. 510-516 ◽  
Author(s):  
Kathrine Eggers Pedersen ◽  
Bjarne Styrishave ◽  
Christian Sonne ◽  
Rune Dietz ◽  
Bjørn Munro Jenssen
Keyword(s):  
Health Effects ◽  
The Arctic ◽  
Arctic Fox ◽  
Vulpes Lagopus ◽  
Potential Health

scholarly journals Main drivers of (poly)phenols effects on human health: metabolites production and(or) gut microbiota-associated metabotypes?

2021 ◽  
Author(s):  
Carlos E. Iglesias-Aguirre ◽  
Adrián Cortés-Martín ◽  
María Á. Ávila-Gálvez ◽  
Juan Antonio Gimenez Bastida ◽  
Maria Victoria Selma ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Endothelial Function ◽  
Olive Oil ◽  
Human Health ◽  
Health Effects ◽  
Interindividual Variability ◽  
Effect Relationship ◽  
Metabolites Production

Despite the high human interindividual variability in response to (poly)phenols consumption, the cause-effect relationship between some dietary (poly)phenols (flavanols and olive oil phenolics) and health effects (endothelial function and prevention...

scholarly journals Review of the potential health effects of light and environmental exposures in underground workplaces

2019 ◽  
Vol 84 ◽  
pp. 201-209 ◽  
Author(s):  
Ei Ei Khaing Nang ◽  
Gulifeiya Abuduxike ◽  
Pawel Posadzki ◽  
Ushashree Divakar ◽  
Nanthini Visvalingam ◽  
...  
Keyword(s):  
Health Effects ◽  
Environmental Exposures ◽  
Potential Health
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