Power Frequency Magnetic Fields Increase Cell Proliferation in the Mammary Gland of Female Fischer 344 Rats but Not Various Other Rat Strains or Substrains

Oncology ◽  
2005 ◽  
Vol 69 (6) ◽  
pp. 486-498 ◽  
Author(s):  
Maren Fedrowitz ◽  
Wolfgang Löscher
Keyword(s):  
Cell Proliferation ◽  
Mammary Gland ◽  
Magnetic Fields ◽  
Fischer 344 Rats ◽  
Rat Strains ◽  
Fischer 344 ◽  
Power Frequency

Interactive effects of methyl-deficiency and dietary restrictionon liver cell proliferation and telomerase activity in Fischer 344 rats pretreated with aflatoxin B1

2000 ◽  
Vol 152 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Ming W Chou ◽  
Marina V Mikhailova ◽  
Jasyl Nichols ◽  
Lionel A Poirier ◽  
Alan Warbritton ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Liver Cell ◽  
Aflatoxin B1 ◽  
Telomerase Activity ◽  
Interactive Effects ◽  
Fischer 344 Rats ◽  
Fischer 344

Testicular Mesotheliomas in Rats Exposed to N-2-Fluorenylacetamide (FAA)

1983 ◽  
Vol 69 (3) ◽  
pp. 195-199 ◽  
Author(s):  
J.R.P. Cabral ◽  
G.E. Neal
Keyword(s):  
Experimental Model ◽  
Control Diet ◽  
Fischer 344 Rats ◽  
Rat Strains ◽  
Chemical Carcinogens ◽  
Rare Type ◽  
Complete Cycle ◽  
Testicular Tumours ◽  
Fischer 344 ◽  
High Incidence

The incidence of testicular mesotheliomas after exposure to the carcinogen N-2-fluorenylacetamide (FAA) was studied in Fischer 344 rats. The animals were fed a carcinogenic diet (containing 0.06 % FAA) for 4 weeks and then a control diet for 1 week. This schedule was carried out for 3 complete cycles (12 weeks). A smaller group of rats was treated with FAA for 1 complete cycle only (4 weeks). One group of untreated controls was also available. The surviving rats were sacrificed at 59 weeks of age. The administration of FAA for 3 complete cycles resulted in a high incidence of liver, testis and Zymbal-gland tumors. The testicular tumours were mesotheliomas and occurred in 9/25 rats. No such tumour was observed in animals treated for 1 cycle only or in untreated controls. The high incidence of testicular mesotheliomas, a rare type of tumour in this and other rat strains, suggests an association with the treatment. The present experimental model may be useful in elucidating the mechanisms of the induction of mesothelial tumours of the testis by chemical carcinogens.

R403 – Epidermal Proliferating Cell Nuclear Antigen in Aging Rats

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P178-P178 ◽  
Author(s):  
Tapan K Bhattacharyya ◽  
Paula Jackson ◽  
J Regan Thomas
Keyword(s):  
Cell Proliferation ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Proliferation Index ◽  
Fischer 344 Rats ◽  
Fischer 344 ◽  
Age Related ◽  
Two Parameters ◽  
Proliferating Cell ◽  
Effect Of Age

Problem To determine if epidermal cell proliferation in colony-raised Fischer 344 rats changes with age and diet. Methods Fischer 344 rats fed ad libitum and calorie-restricted (CR) diets were obtained from the NIA colonies, and young, young adult, and old animals from both groups were used for this study (six in each group). Tissue sections from the dorsal skin (DS) and foot plate (FP) were used for immunohistochemical staining of proliferating cell nuclear antigen (PCNA). The proliferation index (PCNA-I) was computed from counts of stained and total number of keratinocytes. Simultaneous measurements of epidermal thickness were obtained from same sections. Data were analyzed with Excel and SPSS 14.0 software for statistics. Results Two-way analysis of variance (ANOVA) was applied to the data to probe the effect of age, diet, and age-diet interaction. A significant effect of age was noticed in the two parameters i.e., DS PCNA (F 3.96, P .011), FP epidermal width (F 3.37, P .021) and FP PCNA-I (F 9.0, P .000). A significant correlation between DS width and PCNA values was also noted (r 0.5, P .01). Conclusion There is a trend of reduction of PCNA positive cells with increasing age irrespective of thickness of epidermis, and this trend is more apparent in CR rats. Significance This cell proliferation study has implications in relation to CR effect on age-related disease conditions, and biogerontology. Support The study was partially funded by the 2007 Leslie Bernstein grant from AAFPRS foundation.

scholarly journals The Quantification of Cerebral Infarction following Focal Ischemia in the Rat: Influence of Strain, Arterial Pressure, Blood Glucose Concentration, and Age

1988 ◽  
Vol 8 (4) ◽  
pp. 449-461 ◽  
Author(s):  
Danielle Duverger ◽  
Eric T. MacKenzie
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Experimental Diabetes ◽  
Focal Cerebral Ischemia ◽  
Artery Occlusion ◽  
Fischer 344 Rats ◽  
Rat Strains ◽  
Fischer 344 ◽  
Cerebral Artery Occlusion ◽  
Infarcted Tissue

Focal cerebral ischemia was induced by occlusion of the middle cerebral artery in rats. The volumetric assessment of infarcted tissue, 2 days following occlusion, was calculated from the examination of eight preselected coronal sections. Five differing rat strains were examined. A small and variable infarcted volume was seen in Wistar-Kyoto rats; Sprague-Dawley rats had a relatively large, but still variable, infarcted volume. Of the normotensive rat strains, the most reproducible volume of infarcted tissue was seen in Fischer-344 rats; also the absolute value of the infarcted volume did not vary from one series to another in this strain. Chronic arterial hypertension, studied in both normal and stroke-prone spontaneously hypertensive rats, was associated with significantly larger infarction volumes. Age does not change the volume of necrosis: Fischer-344 rats were studied at 3, 9, and 20 months of age, and no significant differences were noted between these ages. Experimental diabetes was induced by the administration of streptozotocin 3 days prior to middle cerebral artery occlusion. Severe hyperglycemia (>400 mg/dl) was associated with a considerably increased volume of infarction. The variability of the resultant lesion is high in the most commonly studied strains, but our results suggest that, for studies in normotensive rats, the use of the Fischer-344 strain produces a standardized and repeatable infarction that may be significantly modified by experimental interventions. Age is not a factor that affects the occlusion-induced infarction; in contrast, both chronic arterial hypertension and experimental diabetes aggravate the histological consequences of middle cerebral artery occlusion in the rat. We conclude that quantitative histological evaluation of infarct size allows a meaningful assessment of the gravity of focal cerebral ischemia.

Absence of sodium chloride preference in Fischer-344 rats

1985 ◽  
Vol 249 (4) ◽  
pp. R438-R442 ◽  
Author(s):  
E. E. Midkiff ◽  
D. A. Fitts ◽  
J. B. Simpson ◽  
I. L. Bernstein
Keyword(s):  
Wistar Rats ◽  
Inbred Strains ◽  
The Other ◽  
Fischer 344 Rats ◽  
Nacl Solution ◽  
Rat Strains ◽  
Taste System ◽  
Fischer 344 ◽  
Sodium Load ◽  
Direct Explanation

Preference for NaCl solutions as a function of concentration was examined in three inbred strains of rats (Munich-Wistar, Buffalo, and Fischer-344) and outbred Wistar rats. Fischer-344 rats were found to differ markedly from the other strains in that they failed to prefer any concentration of NaCl solution to water. This difference did not appear to be due to an insensitivity to the taste of NaCl since they significantly avoided solutions at concentrations (greater than 0.7%) that were strongly preferred by other rat strains. Differences between Fischer-344 and other rat strains also did not appear to be due to a generally anomalous taste system since their intake and preference for prototypes of other basic tastes (sweet, sour, and bitter) were generally similar to those of other strains. Although Fischer-344 rats were somewhat slower than Wistar to excrete a sodium load, it is unlikely that this difference can provide a direct explanation of the aversion of Fischer-344 rats for NaCl.

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