Neuroanatomical Distribution of Cannabinoid Receptor Gene Expression in the Brain of the Rough-Skinned Newt, Taricha granulosa

2006 ◽  
Vol 67 (3) ◽  
pp. 135-149 ◽  
Author(s):  
David M. Hollis ◽  
Emma J. Coddington ◽  
Frank L. Moore
Keyword(s):  
Gene Expression ◽  
Cannabinoid Receptor ◽  
Receptor Gene ◽  
Taricha Granulosa ◽  
The Brain ◽  
Receptor Gene Expression

scholarly journals Implication of the Endocannabinoid System in the Locomotor Hyperactivity Associated with Congenital Hypothyroidism

Endocrinology ◽  
2008 ◽  
Vol 149 (5) ◽  
pp. 2657-2666 ◽  
Author(s):  
Teresa Asúa ◽  
Ainhoa Bilbao ◽  
Miguel Angel Gorriti ◽  
Jose Antonio Lopez-Moreno ◽  
Maria del Mar Álvarez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Hormone ◽  
Cannabinoid Receptor ◽  
Receptor Gene ◽  
Hormone Replacement ◽  
Adult Life ◽  
Endocannabinoid System ◽  
Cb1 Receptor ◽  
Hormone Deficiency ◽  
Receptor Gene Expression

Alterations in motor functions are well-characterized features observed in humans and experimental animals subjected to thyroid hormone dysfunctions during development. Here we show that congenitally hypothyroid rats display hyperactivity in the adult life. This phenotype was associated with a decreased content of cannabinoid receptor type 1 (CB1) mRNA in the striatum and a reduction in the number of binding sites in both striatum and projection areas. These findings suggest that hyperactivity may be the consequence of a thyroid hormone deficiency-induced removal of the endocannabinoid tone, normally acting as a brake for hyperactivity at the basal ganglia. In agreement with the decrease in CB1 receptor gene expression, a lower cannabinoid response, measured by biochemical, genetic and behavioral parameters, was observed in the hypothyroid animals. Finally, both CB1 receptor gene expression and the biochemical and behavioral dysfunctions found in the hypothyroid animals were improved after a thyroid hormone replacement treatment. Thus, the present study suggests that impairment in the endocannabinoid system can underlay the hyperactive phenotype associated with hypothyroidism.

Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa

Andrologia ◽  
2012 ◽  
Vol 45 (4) ◽  
pp. 278-284 ◽  
Author(s):  
A. A. Amoako ◽  
A. K. Gebeh ◽  
E. L. Marczylo ◽  
J. M. Willets ◽  
J. Elson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reference Gene ◽  
Gene Selection ◽  
Cannabinoid Receptor ◽  
Receptor Gene ◽  
Expression Studies ◽  
Selection For ◽  
Gene Expression Studies ◽  
Receptor Gene Expression
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