Etiology of Balkan Endemic Nephropathy and Associated Urothelial Cancer

2006 ◽  
Vol 26 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Vladisav Stefanovic ◽  
Draga Toncheva ◽  
Srebrena Atanasova ◽  
Momir Polenakovic
Keyword(s):  
Urothelial Cancer ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

Balkan endemic nephropathy and associated urothelial cancer

2008 ◽  
Vol 5 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Vladisav Stefanovic ◽  
Zoran Radovanovic
Keyword(s):  
Urothelial Cancer ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

scholarly journals Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

2002 ◽  
Vol 101 (5) ◽  
pp. 500-502 ◽  
Author(s):  
Volker M. Arlt ◽  
Dusan Ferluga ◽  
Marie Stiborova ◽  
Annie Pfohl-Leszkowicz ◽  
Mato Vukelic ◽  
...  
Keyword(s):  
Risk Factor ◽  
Urothelial Cancer ◽  
Aristolochic Acid ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

Molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer

2009 ◽  
Vol 189 ◽  
pp. S38
Author(s):  
Volker M. Arlt ◽  
Heinz H. Schmeiser ◽  
David H. Phillips ◽  
Monica Hollstein
Keyword(s):  
Urothelial Cancer ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

Decreasing incidence of urothelial cancer in a Balkan endemic nephropathy region in Serbia. A surgery based study from 1969 to 1998

2005 ◽  
Vol 53 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Nebojsa Markovic ◽  
Ivan Ignjatovic ◽  
Rade Cukuranovic ◽  
Branislav Petrovic ◽  
Biljana Kocic ◽  
...  
Keyword(s):  
Urothelial Cancer ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania

2012 ◽  
Vol 53 (8) ◽  
pp. 636-641 ◽  
Author(s):  
Heinz H. Schmeiser ◽  
Jill E. Kucab ◽  
Volker M. Arlt ◽  
David H. Phillips ◽  
Monica Hollstein ◽  
...  
Keyword(s):  
Urothelial Cancer ◽  
Aristolochic Acid ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

scholarly journals Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer

2007 ◽  
Vol 28 (11) ◽  
pp. 2253-2261 ◽  
Author(s):  
V. M. Arlt ◽  
M. Stiborova ◽  
J. vom Brocke ◽  
M. L. Simoes ◽  
G. M. Lord ◽  
...  
Keyword(s):  
Urothelial Cancer ◽  
Aristolochic Acid ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

scholarly journals Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answers

2008 ◽  
Vol 1 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Marie Stiborová ◽  
Jiří Hudeček ◽  
Eva Frei ◽  
Heinz Schmeiser
Keyword(s):  
Renal Injury ◽  
Urothelial Cancer ◽  
Aristolochic Acid ◽  
Cytochromes P450 ◽  
Balkan Endemic Nephropathy ◽  
Kidney Fibrosis ◽  
Relative Contribution ◽  
Biotransformation Enzymes ◽  
Endemic Nephropathy

Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answersIngestion of aristolochic acid (AA) is associated with the development of aristolochic acid nephropathy, which is characterized by chronic renal failure, tubulointerstitial fibrosis and urothelial cancer. AA may also cause a similar type of kidney fibrosis with malignant transformation of the urothelium, the Balkan endemic nephropathy. Understanding which enzymes are involved in AA activation and/or detoxication is important in the assessment of a susceptibility to this carcinogen. The most important human enzymes activating AA by simple nitroreductionin vitroare hepatic and renal cytosolic NAD(P)H:quinone oxidoreductase, hepatic microsomal cytochrome P450 1A2 and renal microsomal NADPH:cytcohrome P450 reductase, besides cyclooxygenase, which is highly expressed in urothelial tissue. Despite extensive research, contribution of most of these enzymes to the development of these diseases is still unknown. Hepatic cytochromes P450 were found to detoxicate AA in mice, and thereby protect the kidney from injury. However, which of cytochromes P450 are the most important in this process both in animal models and in humans have not been entirely resolved as yet. In addition, the relative contribution of enzymes found to activate AA to species responsible for induction of urothelial cancer in humans remains still to be resolved.

Is the incidence of Balkan endemic nephropathy decreasing?

2002 ◽  
Vol 50 (1) ◽  
pp. 38-41 ◽  
Author(s):  
P.S. Dimitrov ◽  
V.A. Simeonov ◽  
V.S. Ganev ◽  
W.J.J. Karmaus
Keyword(s):  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

scholarly journals Balkan endemic nephropathy: Role of ochratoxins A through biomarkers

2006 ◽  
Vol 50 (6) ◽  
pp. 519-529 ◽  
Author(s):  
Marcel Castegnaro ◽  
Delphine Canadas ◽  
Terry Vrabcheva ◽  
Theodora Petkova-Bocharova ◽  
Ivan N. Chernozemsky ◽  
...  
Keyword(s):  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy
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