Serotonin Transporter Imaging with [123I]β-CIT SPECT before and after One Year of Citalopram Treatment of Obsessive-Compulsive Disorder

2006 ◽  
Vol 53 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Katarina Stengler-Wenzke ◽  
Ulrich Müller ◽  
Henryk Barthel ◽  
Matthias C. Angermeyer ◽  
Osama Sabri ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Serotonin Transporter ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Before And After ◽  
One Year

Fluoxetine Treatment of Obsessive-Compulsive Disorder

1991 ◽  
Vol 36 (10) ◽  
pp. 723-727 ◽  
Author(s):  
Leslie Solyom ◽  
Carol Solyom ◽  
Barry Ledwidge
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Psychometric Tests ◽  
Symptom Checklist ◽  
Obsessive Compulsive ◽  
Abrupt Withdrawal ◽  
Compulsive Disorder ◽  
Hopkins Symptom Checklist ◽  
Fluoxetine Treatment ◽  
Self Reports ◽  
One Year

Two patients suffering from severe obsessive-compulsive disorder which had proven refractory to clomipramine and/or phenelzine treatment were successfully treated with fluoxetine, a new drug with a strong serotonin uptake inhibiting action. Outcome of treatment was measured on psychometric tests including the Leyton Obsessive Inventory, Hopkins Symptom Checklist-90, Beck Depression Inventory, and daily self-reports of the duration and degree of discomfort of their most severe obsessions. The delay in responding to fluoxetine, the continuing improvement even after one year on the drug, and the prompt relapse with abrupt withdrawal of treatment were noted.

Quality of life in obsessive-compulsive disorder before and after treatment

2005 ◽  
Vol 46 (6) ◽  
pp. 453-459 ◽  
Author(s):  
Steffen Moritz ◽  
Michael Rufer ◽  
Susanne Fricke ◽  
Anne Karow ◽  
Matthias Morfeld ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Before And After

Orbito-frontal cortex and thalamus volumes in the patients with obsessive-compulsive disorder before and after cognitive behavioral therapy

2016 ◽  
Vol 53 (4) ◽  
pp. 243-255 ◽  
Author(s):  
Murad Atmaca ◽  
Hanefi Yildirim ◽  
Seda Yilmaz ◽  
Neslihan Caglar ◽  
Osman Mermi ◽  
...  
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Frontal Cortex ◽  
Obsessive Compulsive Disorder ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Treatment Modalities ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Before And After ◽  
Left And Right

Background The effect of a variety of treatment modalities including psychopharmacological and cognitive behavioral therapy on the brain volumes and neurochemicals have not been investigated enough in the patients with obsessive-compulsive disorder. Therefore, in the present study, we aimed to investigate the effect of cognitive behavioral therapy on the volumes of the orbito-frontal cortex and thalamus regions which seem to be abnormal in the patients with obsessive-compulsive disorder. We hypothesized that there would be change in the volumes of the orbito-frontal cortex and thalamus. Methods Twelve patients with obsessive-compulsive disorder and same number of healthy controls were included into the study. At the beginning of the study, the volumes of the orbito-frontal cortex and thalamus were compared by using magnetic resonance imaging. In addition, volumes of these regions were measured before and after the cognitive behavioral therapy treatment in the patient group. Results The patients with obsessive-compulsive disorder had greater left and right thalamus volumes and smaller left and right orbito-frontal cortex volumes compared to those of healthy control subjects at the beginning of the study. When we compared baseline volumes of the patients with posttreatment ones, we detected that thalamus volumes significantly decreased throughout the period for both sides and that the orbito-frontal cortex volumes significantly increased throughout the period for only left side. Conclusions In summary, we found that cognitive behavioral therapy might volumetrically affect the key brain regions involved in the neuroanatomy of obsessive-compulsive disorder. However, future studies with larger sample are required.

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