Immunohistologic Attempt to Find Carcinogenesis from Hepatic Progenitor Cell in Hepatocellular Carcinoma

2005 ◽  
Vol 22 (5) ◽  
pp. 364-370 ◽  
Author(s):  
Takatsugu Yamamoto ◽  
Takahiro Uenishi ◽  
Masao Ogawa ◽  
Tsuyoshi Ichikawa ◽  
Seikan Hai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Progenitor Cell ◽  
Hepatic Progenitor Cell

scholarly journals EpCAM- and/or NCAM-Expressing Hepatocellular Carcinoma in Which Behavior of Hepatic Progenitor Cell Marker-Positive Cells Are Followed

2019 ◽  
Vol 13 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Atsunori Tsuchiya ◽  
Takeshi Suda ◽  
Chiyumi Oda ◽  
Atsushi Kimura ◽  
Kazunori Hosaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Cells ◽  
Vascular Invasion ◽  
Progenitor Cell ◽  
Cell Marker ◽  
Hepatic Progenitor Cell ◽  
Invasion And Metastasis ◽  
Metastatic Lesions ◽  
Important Target ◽  
Hepatocellular Carcinomas

Hepatic progenitor cell (HPC) marker-positive hepatocellular carcinomas (HCCs) have recently been extensively analyzed, and their prognosis has been reported as poor compared to HPC marker-negative HCCs. However, previous studies have analyzed the existence of HPC marker-positive cancer cells only in primary lesions, as well as the recurrence rate and prognosis of such tumors. Here, we are the first to report the behavior of HPC marker-positive cancer cells during vascular invasion and metastasis of an HCC. We concurrently analyzed EpCAM- and/or NCAM-expressing cancer cells in the primary, vascular invasion, and metastatic lesions of an HCC. An HCC which includes EpCAM- and/or NCAM-expressing cancer cells has not been previously reported. EpCAM- and/or NCAM-positive cancer cells invaded the vessels and formed heterogeneous populations of these HPC marker-positive cancer cells with HPC marker-negative cancer cells. The frequency of HPC marker-positive cancer colonies and cells in vessels was higher than that in the primary HCC. In the metastatic lesions, EpCAM-positive cancer cells were more frequently detected than NCAM-positive cancer cells, indicating that EpCAM may be more important than NCAM for cancer cell settlement in the metastatic lesions. Furthermore, bigger metastatic tumors tended to include HPC marker-positive cancer cells, suggesting that HPC marker-positive cancer cells have a growth advantage in the metastatic lesions. These results showed that HPC marker-positive cancer cells would be important for vascular invasion and metastasis and suggested that HPC marker-positive cancer cells are an important target in HCC treatment.

P0327 : Analysis of hepatic progenitor cell marker positive hepatocellular carcinoma and their prognostic significance

2015 ◽  
Vol 62 ◽  
pp. S431-S432
Author(s):  
A. Tsuchiya ◽  
Y. Kojima ◽  
S. Seino ◽  
Y. Watanabe ◽  
M. Nomoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Progenitor Cell ◽  
Prognostic Significance ◽  
Cell Marker ◽  
Hepatic Progenitor Cell

scholarly journals Clinical outcome of hepatocellular carcinoma can be predicted by the expression of hepatic progenitor cell markers and serum tumour markers

Oncotarget ◽  
2018 ◽  
Vol 9 (31) ◽  
pp. 21844-21860 ◽  
Author(s):  
Satoshi Seino ◽  
Atsunori Tsuchiya ◽  
Yusuke Watanabe ◽  
Yuzo Kawata ◽  
Yuichi Kojima ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Outcome ◽  
Progenitor Cell ◽  
Tumour Markers ◽  
Hepatic Progenitor Cell ◽  
Cell Markers ◽  
Serum Tumour

scholarly journals Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis

Cancer ◽  
2016 ◽  
Vol 122 (8) ◽  
pp. 1216-1227 ◽  
Author(s):  
Danielle K. DePeralta ◽  
Lan Wei ◽  
Sarani Ghoshal ◽  
Benjamin Schmidt ◽  
Gregory Y. Lauwers ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rat Model ◽  
Progenitor Cell ◽  
Cell Activation ◽  
Hepatic Progenitor Cell

MRI features of hepatocellular carcinoma expressing progenitor cell markers

2011 ◽  
pp. n/a-n/a
Author(s):  
Hyeon Tae Jeong ◽  
Myeong-Jin Kim ◽  
Yeo-Eun Kim ◽  
Young Nyun Park ◽  
Gi Hong Choi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Progenitor Cell ◽  
Cell Markers ◽  
Mri Features

Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study

2018 ◽  
Vol 32 (3) ◽  
pp. e13203 ◽  
Author(s):  
Regina Cheuk-lam Lo ◽  
Kristy Kwan-shuen Chan ◽  
Carmen Oi-ning Leung ◽  
Irene Oi-lin Ng
Keyword(s):  
Progenitor Cell ◽  
Immunohistochemical Study ◽  
Acute Cellular Rejection ◽  
Hepatic Progenitor Cell ◽  
Cell Markers ◽  
Cellular Rejection
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