Extended Liver Resection and Hepatic Ischemia in Pigs: A New, Potentially ReversibleModel to Induce Acute Liver Failure and Study Artificial Liver Support Systems

2005 ◽  
Vol 37 (6) ◽  
pp. 365-369 ◽  
Author(s):  
R. Ladurner ◽  
B. Hochleitner ◽  
S. Schneeberger ◽  
U. Barnas ◽  
A. Krismer ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Support Systems ◽  
Artificial Liver ◽  
Liver Support ◽  
Hepatic Ischemia ◽  
Artificial Liver Support ◽  
Extended Liver Resection

scholarly journals Present status of artificial liver support for acute liver failure in Japan

Kanzo ◽  
2012 ◽  
Vol 53 (8) ◽  
pp. 530-533 ◽  
Author(s):  
Keiichi Fujiwara ◽  
Osamu Yokosuka ◽  
Shigeto Oda ◽  
Shinju Arata ◽  
Kazuaki Inoue ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Present Status ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support

Albumin Dialysis With a Noncell Artificial Liver Support Device in Patients With Acute Liver Failure

2013 ◽  
Vol 159 (8) ◽  
pp. 522 ◽  
Author(s):  
Faouzi Saliba ◽  
Christophe Camus ◽  
François Durand ◽  
Philippe Mathurin ◽  
Alexia Letierce ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Artificial Liver ◽  
Albumin Dialysis ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Support Device

scholarly journals Establishment of artificial liver support by on-line hemodiafiltration for patients with acute liver failure

Kanzo ◽  
2012 ◽  
Vol 53 (1) ◽  
pp. 7-17 ◽  
Author(s):  
Shinju Arata ◽  
Yoshihiro Moriwaki ◽  
Kazuhisa Takayama ◽  
Manabu Morimoto ◽  
Kazushi Numata ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
On Line

scholarly journals Serum Lactate: Creatinine Ratio as a Prognostic Marker for Liver Failure Patients Treated by artificial liver support systems

2020 ◽  
Author(s):  
Shuilin Sun ◽  
Ling Chen ◽  
Guanlin Zhou ◽  
Lili Guo ◽  
Yunquan Cai ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support Systems ◽  
Cohort Analysis ◽  
Proton Nuclear Magnetic Resonance ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Time Activity ◽  
Middle Stage ◽  
Death Group

Abstract Background: To screen potential serum prognostic markers for patients with liver failure treated by artificial liver support systems (ALSSs).Methods: Serum samples were obtained from 57 liver-failure patients before and after ALSSs therapy and analyzed by proton nuclear magnetic resonance. The diagnostic values were evaluated by calculation of the area under a receiver-operating characteristic curve (AUROC). Two retrospective analyses were further employed.Results: Metabonomics analysis showed that ratios of creatine:creatinine, taurine:creatinine, and lactate:creatinine were significantly altered and restored to normal levels after ALSSs treatment. The ratio of lactate:creatinine showed the highest AUROC value (0.650), which was higher than that of the prothrombin time activity (PTA, 0.562). A total of 105 cases of retrospective analysis showed that serum lactate:creatinine ratios among the liver-failure patients were 0.038 ± 0.002 (survival group, n=48), 0.048 ± 0.005 (three-month death group, n=24), and 0.052 ± 0.005 (one-month death group, n=33), which was significantly negatively correlated with survival (r= - 0.26). Another retrospective cohort analysis (n=81) of the early to middle stage liver-failure patients treated by ALSSs showed that the AUROC of the lactate:creatinine ratio for diagnosis of those who survived for one subsequent month was 0.827, which was higher than that of PTA (0.628) and lactate (0.765).Conclusion: The serum lactate:creatinine ratio may be a more sensitive measure than either the PTA or the lactate to evaluate the prognosis of ALSSs treatment in early to middle stage of liver-failure patients. This finding is worthy of further study in clinical applications.

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