Different breakage-prone regions on chromosome 1 detected in t(11;14)-positive mantle cell lymphoma cell lines and multiple myeloma cell lines are associated with different tumor progession-related mechanisms

2006 ◽  
Vol 112 (3-4) ◽  
pp. 213-221 ◽  
Author(s):  
C. Rudolph ◽  
T. Liehr ◽  
D. Steinemann ◽  
M. Emura ◽  
M. Daibata ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Myeloma Cell ◽  
Lymphoma Cell ◽  
Chromosome 1 ◽  
Multiple Myeloma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

scholarly journals A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines

2015 ◽  
Vol 87 (4) ◽  
pp. 285-288 ◽  
Author(s):  
Sophie Maïga ◽  
Carole Brosseau ◽  
Géraldine Descamps ◽  
Christelle Dousset ◽  
Patricia Gomez-Bougie ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Flow Cytometry ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell ◽  
Simple Flow

Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours

2002 ◽  
Vol 199 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Raymond Lai ◽  
George Z Rassidakis ◽  
L Jeffrey Medeiros ◽  
Vasiliki Leventaki ◽  
Micheal Keating ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

scholarly journals Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines [see comments]

Blood ◽  
1996 ◽  
Vol 88 (2) ◽  
pp. 674-681 ◽  
Author(s):  
M Chesi ◽  
PL Bergsagel ◽  
LA Brents ◽  
CM Smith ◽  
DS Gerhard ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cyclin D1 ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
Myeloma Cell ◽  
Switch Region ◽  
Chromosomal Locus ◽  
Multiple Myeloma Cell ◽  
Mantle Cell ◽  
Switch Regions

Translocations involving the IgH locus at chromosomal locus 14q32.3 are a common event in many B-cell malignancies. The translocations, which generally occur into JH and switch regions, are mediated by errors in the two developmentally regulated, lymphocyte-specific pathways: VDJ- and switch-mediated recombination. Dysregulation of cyclin D1 by a t(11;14)(q13;q32) translocation occurs in most cases of mantle-cell lymphoma and in approximately 30% of multiple myeloma (MM) tumors in which a 14q32 translocation can be detected. We show here that in two of three myeloma lines that overexpress cyclin D1, there is an 11;14 translocation into a gamma switch region, suggesting an error in switch recombination. By contrast, 11;14 translocations in mantlecell lymphoma are invariably into or near a JH segment, suggesting an error in VDJ recombination. This is consistent with the fact that myeloma cells have undergone lgH switch recombination, whereas mantle-cell lymphoma cells generally have not.

Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines

2006 ◽  
Vol 30 (8) ◽  
pp. 923-934 ◽  
Author(s):  
Jordi Camps ◽  
Itziar Salaverria ◽  
Maria J. Garcia ◽  
Esther Prat ◽  
Sílvia Beà ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Genomic Imbalances ◽  
Karyotypic Variability ◽  
Mantle Cell

Combining Ibrutinib with Chk1 Inhibitors Synergistically Targets Mantle Cell Lymphoma Cell Lines

2018 ◽  
Vol 13 (2) ◽  
pp. 235-245 ◽  
Author(s):  
Valentina Restelli ◽  
Monica Lupi ◽  
Micaela Vagni ◽  
Rosaria Chilà ◽  
Francesco Bertoni ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

scholarly journals Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines

Mobile DNA ◽  
2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Witold Tatkiewicz ◽  
James Dickie ◽  
Franchesca Bedford ◽  
Alexander Jones ◽  
Mark Atkin ◽  
...  
Keyword(s):  
Protein Expression ◽  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Human Endogenous Retrovirus ◽  
Rna Seq ◽  
Tissue Specific ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell

Abstract Background The cell-surface attachment protein (Env) of the HERV-K(HML-2) lineage of endogenous retroviruses is a potentially attractive tumour-associated antigen for anti-cancer immunotherapy. The human genome contains around 100 integrated copies (called proviruses or loci) of the HERV-K(HML-2) virus and we argue that it is important for therapy development to know which and how many of these contribute to protein expression, and how this varies across tissues. We measured relative provirus expression in HERV-K(HML-2), using enriched RNA-Seq analysis with both short- and long-read sequencing, in three Mantle Cell Lymphoma cell lines (JVM2, Granta519 and REC1). We also confirmed expression of the Env protein in two of our cell lines using Western blotting, and analysed provirus expression data from all other relevant published studies. Results Firstly, in both our and other reanalysed studies, approximately 10% of the transcripts mapping to HERV-K(HML-2) came from Env-encoding proviruses. Secondly, in one cell line the majority of the protein expression appears to come from one provirus (12q14.1). Thirdly, we find a strong tissue-specific pattern of provirus expression. Conclusions A possible dependency of Env expression on a single provirus, combined with the earlier observation that this provirus is not present in all individuals and a general pattern of tissue-specific expression among proviruses, has serious implications for future HERV-K(HML-2)-targeted immunotherapy. Further research into HERV-K(HML-2) as a possible tumour-associated antigen in blood cancers requires a more targeted, proteome-based, screening protocol that will consider these polymorphisms within HERV-K(HML-2). We include a plan (and necessary alignments) for such work.

scholarly journals Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell lines

2012 ◽  
Vol 40 (8) ◽  
pp. 646-656.e2 ◽  
Author(s):  
Ana Lopez-Campistrous ◽  
Xiaohua Song ◽  
Adam J. Schrier ◽  
Paul A. Wender ◽  
Nancy A. Dower ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell ◽  
Induced Apoptosis

The cytotoxic effects of bendamustine in combination with cytarabine in mantle cell lymphoma cell lines

2012 ◽  
Vol 48 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Carlo Visco ◽  
Silvia Castegnaro ◽  
Katia Chieregato ◽  
Martina Bernardi ◽  
Elena Albiero ◽  
...  
Keyword(s):  
Mantle Cell Lymphoma ◽  
Cell Lines ◽  
Cell Lymphoma ◽  
Lymphoma Cell ◽  
Cytotoxic Effects ◽  
Mantle Cell Lymphoma Cell ◽  
Mantle Cell
Sign in / Sign up

Export Citation Format

Share Document