Proteinuria and Fusion of Podocyte Foot Processes in Rats after Infusion of Cytokine from Patients with Idiopathic Minimal Lesion Nephrotic Syndrome

2005 ◽  
Vol 102 (3-4) ◽  
pp. e105-e112 ◽  
Author(s):  
Eduardo H. Garin ◽  
Paul F. Laflam ◽  
Karl Muffly
Keyword(s):  
Nephrotic Syndrome ◽  
Minimal Lesion Nephrotic Syndrome

Daily Single-Dose and Daily Reduced-Dose Prednisone Therapy for Children With the Nephrotic Syndrome

PEDIATRICS ◽  
1989 ◽  
Vol 83 (5) ◽  
pp. 694-699
Author(s):  
Barry L. Warshaw ◽  
Leonard C. Hymes
Keyword(s):  
Nephrotic Syndrome ◽  
Single Dose ◽  
Divided Dose ◽  
Initial Therapy ◽  
Mean Response Time ◽  
Reduced Dose ◽  
Frequent Relapses ◽  
Initial Onset ◽  
Nephrotic Children ◽  
Minimal Lesion Nephrotic Syndrome

Most current reference sources recommend that initial therapy for minimal lesion nephrotic syndrome consist of prednisone, 60 mg/m2 per 24 hours or 2 mg/kg per 24 hours, given in divided doses, and that this regimen be repeated for each relapse. The need for divided-dose daily-administered prednisone is predicated on anecdotal observations that single-dose daily administration is not effective. Because single-dose daily-administered and reduced-dose daily-administered prednisone has been used to treat this condition for several years, experience with these regimens in nephrotic children was analyzed. Forty-one patients were studied, including 22 treated from the onset of their disease. Of these 22, 17 (77%) responded to single-dose daily-administered prednisone (2 mg/kg); after subsequent biospy, each of the nonresponders proved to have lesions other than minimal change disease. The mean response time with single-dose daily-administered prednisone (9.6 days for treatment of the initial onset of nephrotic syndrome and 11.1 days for treatment of relapses) was comparable to that previously reported with divided-dose regimens. In 14 patients with frequent relapses, a single reduced-dose daily-administered dose of prednisone (0.2 to 1.5 mg/kg/d) successfully induced remissions in 55 of 63 relapse episodes. It is concluded that a single morning dose of prednisone effectively induces remission in children with minimal lesion nephrotic syndrome. Among selected patients with frequent relapses, additional steroid sparing may be achieved by the use of this regimen with reduced doses during treatment of relapses.

scholarly journals Friedreich’s Ataxia With Nephrotic Syndrome and Convulsive Disorder: Clinical and Neurophysiological Studies With Renal and Nerve Biopsies and An Autopsy

1981 ◽  
Vol 8 (1) ◽  
pp. 55-60 ◽  
Author(s):  
G.V. Watters ◽  
S.H. Zlotkin ◽  
B.S. Kaplan ◽  
P. Humphreys ◽  
K.N. Drummond
Keyword(s):  
Nephrotic Syndrome ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
High Dose ◽  
Eeg Abnormalities ◽  
Progressive Ataxia ◽  
Neurophysiological Studies ◽  
Dose Prednisone ◽  
Minimal Lesion Nephrotic Syndrome ◽  
Spike Wave

SUMMARYIn a sibship of four, Friedreich’s ataxia and minimal lesion nephrotic syndrome occurred in two siblings, a third sibling had Friedreich’s ataxia, but no evidence of nephrotic syndrome; the fourth sibling had neither condition. The chance of Friedreich’s ataxia and minimal lesion nephrotic syndrome occurring in two siblings is small, and suggested a common immunological abnormality. High dose prednisone and antimetabolites given for the nephrotic syndrome did not appear to affect the course of Friedreich’s ataxia.The two siblings with Friedreich’s ataxia and nephrotic syndrome developed epilepsy at age 15 years. All three children with Friedreich’s ataxia had abnormal electroencephalograms (EEGs). These epileptiform EEG abnormalities were probably inherited from the mother, who had spike wave epilepsy. The neurologic deficits of Friedreich’s ataxia, in turn, may have allowed the EEG trait to be expressed as a seizure disorder. The progressive ataxia and epileptic, sometimes myoclonic, seizures in these patients and the dentate nucleus changes in the autopsied patient were consistent with the diagnosis of dyssynergia cerebellaris myoclonica. This suggested that the latter disorder may represent a coincidence of two genetic entities: Friedreich’s ataxia and spike wave epilepsy.

scholarly journals HYPERRENINEMIC ACUTE RENAL INSUFFICIENCY AND HYPERTENSION IN MINIMAL-LESION NEPHROTIC SYNDROME

1977 ◽  
Vol 11 (4) ◽  
pp. 553-553
Author(s):  
Ronald J Kallen ◽  
Yuet Mel Ooi ◽  
Kenneth Calabrese ◽  
William Michener
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Insufficiency ◽  
Acute Renal Insufficiency ◽  
Minimal Lesion Nephrotic Syndrome

Thymoma associated with myasthenia gravis and minimal lesion nephrotic syndrome

1999 ◽  
Vol 33 (5) ◽  
pp. e4.1-e4.4 ◽  
Author(s):  
Catherine Lasseur ◽  
Christian Combe ◽  
Colette Deminière ◽  
Jean-Luc Pellegrin ◽  
Michel Aparicio
Keyword(s):  
Nephrotic Syndrome ◽  
Myasthenia Gravis ◽  
Minimal Lesion Nephrotic Syndrome
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