HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

2005 ◽  
pp. 72-83 ◽  
Author(s):  
Magali Rabot ◽  
Julie Tabiasco ◽  
Beata Polgar ◽  
Maryse Aguerre-Girr ◽  
Alain Berrebi ◽  
...  
Keyword(s):  
Nk Cell ◽  
Hla Class I ◽  
Cell Receptor ◽  
Class I ◽  
Receptor Interaction ◽  
Decidua Basalis ◽  
Functional Consequences ◽  
Nk Cell Receptor ◽  
Human Decidua ◽  
Early Human

scholarly journals Back signaling of HLA class I molecules and T/ NK cell receptor ligands in epithelial cells reflects the rejection‐specific microenvironment in renal allograft biopsies

2019 ◽  
Vol 19 (10) ◽  
pp. 2692-2704 ◽  
Author(s):  
Johanna Egelkamp ◽  
Evgeny Chichelnitskiy ◽  
Jenny F. Kühne ◽  
Franziska Wandrer ◽  
Kerstin Daemen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Renal Allograft ◽  
Nk Cell ◽  
Hla Class I ◽  
Cell Receptor ◽  
Class I ◽  
Receptor Ligands ◽  
Hla Class I Molecules ◽  
Nk Cell Receptor

Analyses of HLA-C–specific KIR repertoires in donors with group A and B haplotypes suggest a ligand-instructed model of NK cell receptor acquisition

Blood ◽  
2011 ◽  
Vol 117 (1) ◽  
pp. 98-107 ◽  
Author(s):  
Kathrin Schönberg ◽  
Martina Sribar ◽  
Jürgen Enczmann ◽  
Johannes C. Fischer ◽  
Markus Uhrberg
Keyword(s):  
Nk Cells ◽  
Nk Cell ◽  
Hla Class I ◽  
Cell Receptor ◽  
Suppressive Effect ◽  
Class I ◽  
Nk Cell Differentiation ◽  
Group A ◽  
Common Group ◽  
Group B

Abstract To determine the influence of KIR and HLA class I polymorphism on human NK cell repertoires, 32 different clonotypes representing all possible combinations of 4 inhibitory KIR and NKG2A were analyzed by multicolor flow cytometry. In donors homozygous for the common group A KIR haplotype, a significant influence of HLA-C ligands was seen: KIR repertoires were dominated by clonotypes expressing a single KIR for the respective cognate ligand, either the C1-specific KIR2DL3 or C2-specific KIR2DL1. In contrast, in donors possessing the polymorphic group B haplotypes, a similar adaptation to cognate HLA-C was lacking. We suggest that this discrepancy is largely the result of a suppressive effect of the group B–specific KIR2DL2 on the frequency of KIR2DL1+ NK cells. In functional assays, KIR2DL2 not only recognized C1 but also C2 ligands, showing overlapping specificity with KIR2DL1. Moreover, using an NK cell differentiation assay we show sequential acquisition of KIR2DL2 before KIR2DL1 on developing NK cells. Together, these observations are compatible with a ligand-instructed model of NK cell education, in which recognition of HLA class I by an inhibitory receptor (KIR2DL2) suppresses subsequent expression of a second receptor (KIR2DL1) of related specificity. Importantly, the ligand-instructed model fits to the observed KIR repertoires in both broad KIR haplotype groups.

scholarly journals The Emerging Role of HLA-E-Restricted CD8+T Lymphocytes in the Adaptive Immune Response to Pathogens and Tumors

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Gabriella Pietra ◽  
Chiara Romagnani ◽  
Claudia Manzini ◽  
Lorenzo Moretta ◽  
Maria Cristina Mingari
Keyword(s):  
Cell Function ◽  
Nk Cell ◽  
Adaptive Immune Response ◽  
Human Leukocyte ◽  
Hla Class I ◽  
Cell Receptor ◽  
Class I ◽  
Mhc Class I Molecule ◽  
Associated Proteins ◽  
Acquired Immune Responses

Human leukocyte antigen (HLA)-E is a nonclassical major histocompatibility complex (MHC) class I molecule of limited sequence variability that is expressed by most tissues albeit at low levels. HLA-E has been first described as the ligand of CD94/NKG2 receptors expressed mainly by natural killer (NK) cells, thus confining its role to the regulation of NK-cell function. However, recent evidences obtained by our and other groups indicate that HLA-E complexed with peptides can interact withαβT-cell receptor (TCR) expressed on CD8+T cells. Although, HLA-E displays a selective preference for nonameric peptides, derived from the leader sequence of various HLA class I alleles, several reports indicate that it can present also “noncanonical” peptides derived from both stress-related and pathogen-associated proteins. Because HLA-E displays binding specificity for innate CD94/NKG2 receptors, as well as all the features of an antigen-presenting molecule, its role in both natural and acquired immune responses has recently been re-evaluated.

Quantifying the reduction in accessibility of the inhibitory NK cell receptor Ly49A caused by binding MHC class I proteins in cis

2007 ◽  
Vol 37 (2) ◽  
pp. 516-527 ◽  
Author(s):  
Katja E. Andersson ◽  
Geoffrey S. Williams ◽  
Daniel M. Davis ◽  
Petter Höglund
Keyword(s):  
Mhc Class I ◽  
Nk Cell ◽  
Cell Receptor ◽  
Class I ◽  
Nk Cell Receptor ◽  
In Cis

scholarly journals A bird's eye view of NK cell receptor interactions with their MHC class I ligands

2015 ◽  
Vol 267 (1) ◽  
pp. 148-166 ◽  
Author(s):  
Philippa M. Saunders ◽  
Julian P. Vivian ◽  
Geraldine M. O'Connor ◽  
Lucy C. Sullivan ◽  
Phillip Pymm ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Nk Cell ◽  
Cell Receptor ◽  
Class I ◽  
Receptor Interactions ◽  
Nk Cell Receptor

scholarly journals Ly-49s3 Is a Promiscuous Activating Rat NK Cell Receptor for Nonclassical MHC Class I-Encoded Target Ligands

2002 ◽  
Vol 169 (1) ◽  
pp. 22-30 ◽  
Author(s):  
Christian Naper ◽  
Shigenari Hayashi ◽  
Lise Kveberg ◽  
Eréne C. Niemi ◽  
Lewis L. Lanier ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Nk Cell ◽  
Cell Receptor ◽  
Class I ◽  
Nonclassical Mhc ◽  
Nk Cell Receptor

scholarly journals Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8+ T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia

2019 ◽  
Vol 20 (6) ◽  
pp. 1454 ◽  
Author(s):  
Wiebke Pump ◽  
Thomas Kraemer ◽  
Trevor Huyton ◽  
Gia-Gia Hò ◽  
Rainer Blasczyk ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Surface ◽  
Cd8 T Cells ◽  
Nk Cell ◽  
Hla Class I ◽  
Cell Receptor ◽  
Class I ◽  
Cell Surface Expression ◽  
Effector Memory ◽  
Surface Stability

On healthy cells the non-classical HLA class Ib molecule HLA-E displays the cognate ligand for the NK cell receptor NKG2A/CD94 when bound to HLA class I signal peptide sequences. In a pathogenic situation when HLA class I is absent, HLA-E is bound to a diverse set of peptides and enables the stimulatory NKG2C/CD94 receptor to bind. The activation of CD8+ T cells by certain p:HLA-E complexes illustrates the dual role of this low polymorphic HLA molecule in innate and adaptive immunity. Recent studies revealed a shift in the HLA-E peptide repertoire in cells with defects in the peptide loading complex machinery. We recently showed that HLA-E presents a highly diverse set of peptides in the absence of HLA class Ia and revealed a non-protective feature against NK cell cytotoxicity mediated by these peptides. In the present study we have evaluated the molecular basis for the impaired NK cell inhibition by these peptides and determined the cell surface stability of individual p:HLA-E complexes and their binding efficiency to soluble NKG2A/CD94 or NKG2C/CD94 receptors. Additionally, we analyzed the recognition of these p:HLA-E epitopes by CD8+ T cells. We show that non-canonical peptides provide stable cell surface expression of HLA-E, and these p:HLA-E complexes still bind to NKG2/CD94 receptors in a peptide-restricted fashion. Furthermore, individual p:HLA-E complexes elicit activation of CD8+ T cells with an effector memory phenotype. These novel HLA-E epitopes provide new implications for therapies targeting cells with abnormal HLA class I expression.

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