Expression of p53 Protein in Esophageal Squamous Cell Carcinoma: Relation to Hypoxia-Inducible Factor-1α, Angiogenesis and Apoptosis

Pathobiology ◽  
2005 ◽  
Vol 72 (4) ◽  
pp. 179-185 ◽  
Author(s):  
Shigeru Kimura ◽  
Yasuhiko Kitadai ◽  
Toshio Kuwai ◽  
Shinji Tanaka ◽  
Jun Hihara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
P53 Protein ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α

Hypoxia inducible factor-1α cooperates with histone Lys methylation to predict prognosis in esophageal squamous cell carcinoma

2021 ◽  
Author(s):  
Xiaohui Shen ◽  
Yiping Li ◽  
Ying Xu ◽  
Min Liu ◽  
Qin Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histone Methylation ◽  
Hypoxia Inducible Factor ◽  
Histone H3 ◽  
Survival Prediction ◽  
Hypoxia Inducible Factor 1Α ◽  
Kaplan Meier

Aim: To investigate hypoxia inducible factor-1α (HIF-1α) and histone methylation markers as potential indicators of prognosis in esophageal squamous cell carcinoma (ESCC). Patients & methods: The prognostic value of HIF-1α and histone methylation markers levels was analyzed using Kaplan–Meier survival analysis. Results: HIF-1α protein expression was higher in ESCC tumors than in paracancerous tissues. Histone H3 Lys9 trimethylation (H3K9me3), histone H3 Lys27 trimethylation (H3K27me3), histone H3 Lys4 trimethylation (H3K4me3) and histone H4 Lys20 trimethylation (H4K20me3) were significantly upregulated in ESCC tissues. HIF-1α was only positively correlated with H3K9me3 and H3K4me3 expression. Kaplan–Meier analysis indicated that H3K9me3, H3K27me3, H4K20me3 and histone H3 Lys36 trimethylation (H3K36me3) were independent indicators of prognosis for ESCC. Conclusion: This study identified a pattern of epigenetic methylation markers and HIF-1α expression in ESCC, and their combined evaluation might improve survival prediction for ESCC patients.

Sign in / Sign up

Export Citation Format

Share Document