Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Dermatology ◽  
2005 ◽  
Vol 211 (2) ◽  
pp. 98-102 ◽  
Author(s):  
Stefan Trachsler ◽  
Ralph M. Trüeb
Keyword(s):  
Differential Diagnosis ◽  
Direct Immunofluorescence

Direct Immunofluorescence as a Helpful Tool for the Differential Diagnosis of Oral Lichen Planus and Oral Lichenoid Lesions

2018 ◽  
Vol 40 (7) ◽  
pp. 491-497 ◽  
Author(s):  
Yasmin Yamanaka ◽  
Maurício Yamashita ◽  
Lara M. A. Innocentini ◽  
Leandro D. Macedo ◽  
Fernando Chahud ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Direct Immunofluorescence ◽  
Helpful Tool ◽  
Oral Lichenoid Lesions ◽  
Oral Lichen

scholarly journals Histopathological Evaluation of Behçet's Disease and Identification of New Skin Lesions

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Özgür Gündüz
Keyword(s):  
Differential Diagnosis ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Skin Lesions ◽  
Direct Immunofluorescence ◽  
Inflammatory Disorder ◽  
Behcet's Disease ◽  
Histopathological Evaluation ◽  
New Skin

Behçet's disease (BD) is a multisystemic, relapsing inflammatory disorder with an obscure etiology and pathogenesis. Diagnosis depends on the clinician's ability to identify a group of nonspecific mucocutaneous lesions, which also manifest in a number of other diseases. In recent years, there has been an increase in the studies focusing on the histopathological aspects of Behçet's disease diagnostic mucocutaneous lesions. Their results emphasize the value of histopathology and direct immunofluorescence (DIF) in the differential diagnosis of Behçet's disease.

Bullous Scabies: Clinical, Dermoscopic, and Pathologic Characteristics of 10 Patients

2021 ◽  
Author(s):  
Feng-Zeng Li ◽  
Meng Jia ◽  
Ke-Jun Chen ◽  
Qian Ye ◽  
Sheng Fang
Keyword(s):  
Differential Diagnosis ◽  
Basement Membrane ◽  
Skin Biopsy ◽  
Poor Response ◽  
Neutrophil Infiltration ◽  
Basement Membrane Zone ◽  
Direct Immunofluorescence ◽  
Skin Scraping ◽  
Pathological Characteristics ◽  
Clinical Variant

Bullous scabies (BS) is a rare atypical clinical variant of scabies and is easily confused with bullous disorders. The diagnosis of BS is always a challenge, and physicians often misdiagnose BS patients. Patients with BS admitted from 2012 to 2020 were enrolled in this study. The clinical, dermoscopic, and pathological characteristics of the patients were analyzed retrospectively. Ten patients with BS were enrolled in this study. Seven of the 10 patients were male. The bullae were most commonly found on the thighs and arms (80% of patients). Only 30% of patients (3/10) tested positive for mites and/or eggs by the initial skin scraping, but 100% (5/5) of the patients who received dermoscopy tested positive. Among these 10 patients, only five received a skin biopsy. Subepidermal (4/5) and intraepidermal (1/5) bullae with eosinophil and neutrophil infiltration were observed in five patients. Direct immunofluorescence (DIF) indicated linear deposition of IgG in the basement membrane zone in three patients. Physicians should consider the possibility of BS in patients with blisters, pruritus, and poor response to corticosteroids. Dermoscopy should be prioritized for the differential diagnosis of BS to exclude other bullous disorders. Finally, a biopsy should be performed on each patient with bullae.

Tumor Diagnosis

1982 ◽  
Vol 40 ◽  
pp. 262-265
Author(s):  
Bruce Mackay
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Differential Diagnosis ◽  
Light Microscopy ◽  
Clinical Examination ◽  
Ultrastructural Study ◽  
Diagnostic Procedures ◽  
Specific Diagnosis ◽  
Transmission Electron ◽  
Microscopic Diagnosis

The broadest application of transmission electron microscopy (EM) in diagnostic medicine is the identification of tumors that cannot be classified by routine light microscopy. EM is useful in the evaluation of approximately 10% of human neoplasms, but the extent of its contribution varies considerably. It may provide a specific diagnosis that can not be reached by other means, but in contrast, the information obtained from ultrastructural study of some 10% of tumors does not significantly add to that available from light microscopy. Most cases fall somewhere between these two extremes: EM may correct a light microscopic diagnosis, or serve to narrow a differential diagnosis by excluding some of the possibilities considered by light microscopy. It is particularly important to correlate the EM findings with data from light microscopy, clinical examination, and other diagnostic procedures.

The Preschool Stuttering Screen for Health Care Professionals

2011 ◽  
Vol 21 (2) ◽  
pp. 59-62
Author(s):  
Joseph Donaher ◽  
Christina Deery ◽  
Sarah Vogel
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Differential Diagnosis ◽  
Preschool Children ◽  
Health Care Professionals ◽  
Healthcare Professionals ◽  
Evidence Based ◽  
Developmental Profile

Healthcare professionals require a thorough understanding of stuttering since they frequently play an important role in the identification and differential diagnosis of stuttering for preschool children. This paper introduces The Preschool Stuttering Screen for Healthcare Professionals (PSSHP) which highlights risk factors identified in the literature as being associated with persistent stuttering. By integrating the results of the checklist with a child’s developmental profile, healthcare professionals can make better-informed, evidence-based decisions for their patients.

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