The canine sarcoglycan delta gene: BAC clone contig assembly, chromosome assignment and interrogation as a candidate gene for dilated cardiomyopathy in Dobermann dogs

2005 ◽  
Vol 111 (2) ◽  
pp. 140-146 ◽  
Author(s):  
P. Stabej ◽  
P.A.J. Leegwater ◽  
S. Imholz ◽  
S.A. Versteeg ◽  
C. Zijlstra ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Candidate Gene ◽  
Contig Assembly ◽  
Bac Clone ◽  
Chromosome Assignment ◽  
Delta Gene

scholarly journals Bovine cardiac troponin I gene (<i>TNNI3</i>) as a candidate gene for bovine dilated cardiomyopathy

2009 ◽  
Vol 52 (2) ◽  
pp. 113-123
Author(s):  
M. Owczarek-Lipska ◽  
G. Dolf ◽  
K. E. Guziewicz ◽  
T. Leeb ◽  
C. Schelling ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Dilated Cardiomyopathy ◽  
Candidate Gene ◽  
Expression Analysis ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Significant Difference

Abstract. The cardiac troponin complex, which is an important component of the contractile apparatus, is composed of the three subunits troponin I (TnI), troponin C (TnC) and troponin T (TnT). Troponin I is the inhibitory subunit and consists of three isoforms encoded by TNNI1, TNNI2 and TNNI3 genes, respectively. Due to the different types of cardiomyopathies caused by mutations in the TNNI3 gene and its fluorescence in situ hybridization (FISH) mapping on bovine chromosome 18q26, which was shown to be linked to the recessively inherited bovine dilated cardiomyopathy (BDCMP), bovine TNNI3 was considered as candidate gene for BDCMP. Real-time polymerase chain reaction (PCR) TNNI3 expression analysis resulted in a significant difference between BDCMP affected and unaffected animals when normalized to ACTB gene expression, but there was no significant difference in expression when normalized to GAPDH. Northen blotting experiment was in agreement with the expression analysis and did not reveal a significant difference between the group of BDCMP affected and unaffected animals. Sequencing of the bovine TNNI3 gene revealed a single nucleotide polymorphism in intron 6 (c.378+315G>A), but this single nucleotide polymorphism (SNP)was present regardless of the BDCMP status. In summary our data provide evidence to exclude the bovine TNNI3 gene as a candidate for BDCMP.

Computational BAC clone contig assembly for comprehensive genome analysis

2004 ◽  
Vol 40 (1) ◽  
pp. 66-71 ◽  
Author(s):  
Anna Lapuk ◽  
Stanislav Volik ◽  
Robert Vincent ◽  
Koei Chin ◽  
Wen-Lin Kuo ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Contig Assembly ◽  
Bac Clone

scholarly journals The Genetics of Dilated Cardiomyopathy: A Prioritized Candidate Gene Study ofLMNA,TNNT2,TCAP, andPLN

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Marika Hirtle-Lewis ◽  
Katia Desbiens ◽  
Isabelle Ruel ◽  
Nicholas Rudzicz ◽  
Jacques Genest ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Candidate Gene ◽  
Candidate Gene Study ◽  
Gene Study

scholarly journals Candidate Gene Expression Analysis of Toxin-Induced Dilated Cardiomyopathy in the Turkey (Meleagris gallopavo)

2006 ◽  
Vol 85 (12) ◽  
pp. 2216-2221 ◽  
Author(s):  
K.-C. Lin ◽  
K. Gyenai ◽  
R.L. Pyle ◽  
T. Geng ◽  
J. Xu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dilated Cardiomyopathy ◽  
Candidate Gene ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Meleagris Gallopavo

Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann

Gene ◽  
2004 ◽  
Vol 340 (2) ◽  
pp. 241-249 ◽  
Author(s):  
Polona Stabej ◽  
Sandra Imholz ◽  
Serge A. Versteeg ◽  
Carla Zijlstra ◽  
Arnold A. Stokhof ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Candidate Gene

Studies on Ultrastructure and Cytochemistry of Right Ventricular Endomyocardial Biopsy

1990 ◽  
Vol 48 (3) ◽  
pp. 256-257
Author(s):  
Xia Mingyu ◽  
Ma Wengshu ◽  
Wu Xiangh ◽  
Chen Dong
Keyword(s):  
Light Microscopy ◽  
Right Ventricular ◽  
Dilated Cardiomyopathy ◽  
Endomyocardial Biopsy ◽  
Heart Diseases ◽  
Ultrastructural Localization ◽  
Controlled Study ◽  
Myocardial Biopsy ◽  
Morphological Assessment ◽  
Rheumatic Heart

This paper describes morphological and cytochemistry changes of endomyocardial biopsy in 94 patients. The samples of myoicardium were taken from 32 patients with dilated cardiomyopathy, and sdudied with light and electron microscop. The cytochemical studies in some of these patients were performed at histological and ultrastructure level. This paper also reported the result of myocardial biopsy in 33 patients with serious dysrythmia.The result of this controlled study indicates that morphological assessment in both cardiomyopathy and congenital or rheumatic heart diseases showed no special changes. In patients of dilated cardiomyopathy, the decreased activity of myosin ATPase was secondary to cardial failure. The change of succinate dehydrogenase (SDHase) was not significant with light microscopy. But ultrastructural localization of SDHase activity is valuable. Its activity was found to be localized in endomembrane and ridge of the mitochondria, the activity of this enzyme was decrease, normal, or increase. SDHase activity was more intense in cardial myocytes well-functioning, or ultrastructurally well preserved hearts.

A candidate gene study in predicted severe acute pancretitis

2001 ◽  
Vol 120 (5) ◽  
pp. A468-A468 ◽  
Author(s):  
G GALLAGHER ◽  
P CHONG ◽  
J ESKDALE ◽  
A COOK ◽  
S CAIMS ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Candidate Gene Study ◽  
Gene Study ◽  
Acute Pancretitis
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