Cardioprotective Effects of [5-(2-Methyl-5-Fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an Anesthetized Rat Model of Ischemia and Reperfusion Heart Injury

Pharmacology ◽  
2005 ◽  
Vol 75 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Hui-Yul Roh ◽  
In-Sang Jung ◽  
Jung-Woo Park ◽  
Yeo-Pyo Yun ◽  
Kyu-Yang Yi ◽  
...  
Keyword(s):  
Rat Model ◽  
Ischemia And Reperfusion ◽  
Cardioprotective Effects ◽  
Heart Injury

scholarly journals Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced CardiotoxicityIn VitroandIn Vivo

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Hongbo Wang ◽  
Pengfei Yu ◽  
Haitao Gou ◽  
Jianqiao Zhang ◽  
Mei Zhu ◽  
...  
Keyword(s):  
Rat Model ◽  
A549 Cells ◽  
H9c2 Cell ◽  
Protective Agent ◽  
Protective Effects ◽  
Ginsenoside Rh2 ◽  
Cardioprotective Effects ◽  
Heart Injury

Doxorubicin (DOX) is considered as one of the best antineoplastic agents. However, its clinical use is restricted by its associated cardiotoxicity, which is mediated by the production of reactive oxygen species. In this study, 20(S)-ginsenoside Rh2 (Rh2) was explored whether it had protective effects against DOX-induced cardiotoxicity.In vitrostudy on H9C2 cell line, as well asin vivoinvestigation in one mouse and one rat model of DOX-induced cardiomyopathy, was carried out. The results showed that pretreatment with Rh2 significantly increased the viability of DOX-injured H9C2 cells. In the mouse model, Rh2 could suppress the DOX-induced release of the cardiac enzymes into serum and improved the occurred pathological changes through ameliorating the decreased antioxidant biomolecules and the cumulated lipid peroxidation malondialdehyde in heart tissues. In the rat model, Rh2 could attenuate the change of ECG resulting from DOX administration. Furthermore, Rh2 enhanced the antitumor activity of DOX in A549 cells. Our findings thus demonstrated that Rh2 pretreatment could effectively alleviate heart injury induced by DOX, and Rh2 might act as a novel protective agent in the clinical usefulness of DOX.

CARDIOPROTECTIVE EFFECTS OF DIALLYL TRISULFIDE IN A RAT MODEL OF TYPE-1 DIABETES MELLITUS

2018 ◽  
Vol 25 (3) ◽  
pp. 217
Author(s):  
Jovana Jeremic ◽  
Ivan Srejovic ◽  
Vladimir Zivkovic ◽  
Tamara Nikolic Turnic ◽  
Isidora Milosavljevic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Rat Model ◽  
Diallyl Trisulfide ◽  
Cardioprotective Effects

Differential cardioprotective effects of cardiac and non-cardiac adenosine during global ischemia and reperfusion

2007 ◽  
Vol 42 (6) ◽  
pp. S201-S202
Author(s):  
Anwar S. Abd-Elfattah ◽  
Mai Ding ◽  
S. Jamal Mustafa ◽  
Magda A. Mansour ◽  
Farid R. Nomair
Keyword(s):  
Global Ischemia ◽  
Ischemia And Reperfusion ◽  
Cardioprotective Effects

Cardioprotective Effects of a Phlorotannin Extract Against Doxorubicin-Induced Cardiotoxicity in a Rat Model

2017 ◽  
Vol 20 (10) ◽  
pp. 944-950 ◽  
Author(s):  
Hyo-Suk Ahn ◽  
Dong-Hyeon Lee ◽  
Tae-Jung Kim ◽  
Hyeon-Cheol Shin ◽  
Hui-Kyung Jeon
Keyword(s):  
Rat Model ◽  
Cardioprotective Effects

scholarly journals Chemical Ablation Of Purkinje Fibers Diminishes Spontaneous Activity In A Rat Model Of Regional Ischemia And Reperfusion

2009 ◽  
Vol 96 (3) ◽  
pp. 258a-259a
Author(s):  
Matthew W. Kay ◽  
Luther M. Swift ◽  
Huda Asfour ◽  
Craig Forleiter ◽  
Marco A. Mercader ◽  
...  
Keyword(s):  
Spontaneous Activity ◽  
Rat Model ◽  
Ischemia And Reperfusion ◽  
Purkinje Fibers ◽  
Regional Ischemia ◽  
Chemical Ablation

In vivo spectroscopic monitoring of renal ischemia and reperfusion in a rat model

2006 ◽  
Author(s):  
Rajesh N. Raman ◽  
Christopher D. Pivetti ◽  
Dennis L. Matthews ◽  
Christoph Troppmann ◽  
Stavros G. Demos
Keyword(s):  
Rat Model ◽  
Renal Ischemia ◽  
Ischemia And Reperfusion ◽  
Spectroscopic Monitoring
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