Oxidant Stress in Renal Pathophysiology

2005 ◽  
pp. 135-153 ◽  
Author(s):  
M. Ruhul Abid ◽  
Mohammed S. Razzaque ◽  
Takashi Taguchi
Keyword(s):  
Oxidant Stress

Pathogenesis of Age-related Cataract: a systematic review of proteomic studies

2020 ◽  
Vol 17 ◽  
Author(s):  
Christina Karakosta ◽  
Argyrios Tzamalis ◽  
Michalis Aivaliotis ◽  
Ioannis Tsinopoulos
Keyword(s):  
Systematic Review ◽  
Oxidant Stress ◽  
Critical Role ◽  
Human Lens ◽  
Nuclear Cataract ◽  
Cataract Formation ◽  
Post Translational Modification ◽  
Ability To Act ◽  
Age Related

Background/Objective:: The aim of this systematic review is to identify all the available data on human lens proteomics with a critical role to age-related cataract formation in order to elucidate the physiopathology of the aging lens. Materials and Methods:: We searched on Medline and Cochrane databases. The search generated 328 manuscripts. We included nine original proteomic studies that investigated human cataractous lenses. Results:: Deamidation was the major age-related post-translational modification. There was a significant increase in the amount of αA-crystallin D-isoAsp58 present at all ages, while an increase in the extent of Trp oxidation was apparent in cataract lenses when compared to aged normal lenses. During aging, enzymes with oxidized cysteine at critical sites included GAPDH, glutathione synthase, aldehyde dehydrogenase, sorbitol dehydrogenase, and PARK7. Conclusion:: D-isoAsp in αA crystallin could be associated with the development of age-related cataract in human, by contributing to the denaturation of a crystallin, and decreasing its ability to act as a chaperone. Oxidation of Trp may be associated with nuclear cataract formation in human, while the role of oxidant stress in age-related cataract formation is dominant.

Specificity of cytokine profile and oxidant stress in patients with bronchial asthma

2006 ◽  
Vol 25 (2) ◽  
pp. 153-159
Author(s):  
Vladan Cosic ◽  
Vidosava Djordjevic ◽  
Gordana Bjelakovic ◽  
Jasmina Mimic-Oka ◽  
Dusica Pavlovic ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Oxidant Stress ◽  
Cytokine Profile

scholarly journals Effects of Decabrominated Diphenyl Ether Exposure on Growth, Meat Characteristics and Blood Profiles in Broilers

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 565
Author(s):  
Zehui Liu ◽  
Hulong Lei ◽  
Renyong Tang ◽  
Junhua Yang ◽  
Xiulan Guo ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Growth Performance ◽  
Diphenyl Ether ◽  
Oxidant Stress ◽  
White Blood Cells ◽  
Abdominal Fat ◽  
Environmental Pollutant ◽  
Liver And Kidney ◽  
Bde 209 ◽  
Blood Profiles

Decabrominated diphenyl ether (BDE-209) is widely used as a flame retardant and is detected at high levels in the environment. Its toxicities have been reported and have attracted attention. In the present study, broilers were used to determine the response in growth performance, carcass traits, meat quality, blood profiles and antioxidant system to BDE-209 exposure at doses of 0, 0.02, 0.4 and 4 mg/kg. The results showed that BDE-209 exposure at levels of 0.02 or 0.4 mg/kg increased feed intake and decreased feed efficiency. BDE-209 altered the blood profiles, such as reducing the numbers of white blood cells, lymphocytes and neutrophilic granulocytes. As compared with the control, BDE-209 exposure significantly increased abdominal fat percentages of broilers at 64.9–159.5% and adversely affected the selected biochemical indicators, including alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine (CRE), which indicated its toxicity to liver and kidney functions. Moreover, BDE-209 exposure significantly increased plasma malondialdehyde (MDA) concentrations and decreased the activities of glutathione peroxidase (GSH-px) and superoxide dismutase (SOD), which implied aggravating oxidant stress and decline of antioxidant capacity in broilers. In conclusion, our data demonstrated that the environmental pollutant BDE-209 adversely influenced growth performance, increased the deposition of abdominal fat, impaired antioxidant capacity and the immune system and had potential toxicity to the liver and kidney of broilers.

scholarly journals Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 276
Author(s):  
Qun Chen ◽  
Steven Qi ◽  
Laura Hocum-Stone ◽  
Edward Lesnefsky ◽  
Rosemary F. Kelly ◽  
...  
Keyword(s):  
High Risk ◽  
Heart Diseases ◽  
Beta Blockers ◽  
Controlled Trial ◽  
Oxidant Stress ◽  
Perioperative Period ◽  
Antioxidant Therapy ◽  
Ischemic Heart ◽  
Background Information ◽  
Swine Model

Over 240 million non-cardiac operations occur each year and are associated with a 15–20% incidence of adverse perioperative cardiovascular events. Unfortunately, preoperative therapies that have been useful for chronic ischemic heart diseases, such as coronary artery revascularization, antiplatelet agents, and beta-blockers have failed to improve outcomes. In a pre-clinical swine model of ischemic heart disease, we showed that daily administration of ubiquinone (coenzyme Q10, CoQ10) enhances the antioxidant status of mitochondria within chronically ischemic heart tissue, potentially via a PGC1α-dependent mechanism. In a randomized controlled trial, among high-risk patients undergoing elective vascular surgery, we showed that NT Pro-BNP levels are an important means of risk-stratification during the perioperative period and can be lowered with administration of CoQ10 (400 mg/day) for 3 days prior to surgery. The review provides background information for the role of oxidant stress and inflammation during high-risk operations and the potential novel application of ubiquinone as a preoperative antioxidant therapy that might reduce perioperative adverse cardiovascular outcomes.

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