scholarly journals Ischemic Preconditioning Attenuates Portal Venous Plasma Concentrations of Purines following Warm Liver Ischemia in Man

2005 ◽  
Vol 37 (3) ◽  
pp. 144-152 ◽  
Author(s):  
A. Choukèr ◽  
A. Martignoni ◽  
R.J. Schauer ◽  
H.G. Rau ◽  
A. Volk ◽  
...  
Keyword(s):  
Ischemic Preconditioning ◽  
Plasma Concentrations ◽  
Liver Ischemia ◽  
Warm Liver Ischemia ◽  
Venous Plasma

Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury

2010 ◽  
Vol 26 (1) ◽  
pp. 194-200 ◽  
Author(s):  
Hemant Sheth ◽  
Tariq Hafez ◽  
George K Glantzounis ◽  
Alexander M Seifalian ◽  
Barry Fuller ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mitochondrial Activity ◽  
Liver Ischemia ◽  
Bile Composition ◽  
Warm Liver Ischemia

scholarly journals Intestinal ischemic preconditioning reduces liver ischemia reperfusion injury in rats

2016 ◽  
Vol 13 (3) ◽  
pp. 2511-2517 ◽  
Author(s):  
TONG-MIN XUE ◽  
LI-DE TAO ◽  
JIE ZHANG ◽  
PEI-JIAN ZHANG ◽  
XIA LIU ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia

FTY720 Application Following Isolated Warm Liver Ischemia Improves Long-Term Survival and Organ Protection in a Mouse Model

2007 ◽  
Vol 39 (2) ◽  
pp. 493-498 ◽  
Author(s):  
C.P. Kaudel ◽  
M. Frink ◽  
M. van Griensven ◽  
U. Schmiddem ◽  
C. Probst ◽  
...  
Keyword(s):  
Mouse Model ◽  
Liver Ischemia ◽  
Organ Protection ◽  
Term Survival ◽  
Long Term Survival ◽  
Warm Liver Ischemia

scholarly journals Ischemic preconditioning increases GSK-3β/β-catenin levels and ameliorates liver ischemia/reperfusion injury in rats

2015 ◽  
Vol 35 (6) ◽  
pp. 1625-1632 ◽  
Author(s):  
YICHAO YAN ◽  
GUANGYING LI ◽  
XIAOFENG TIAN ◽  
YINGJIANG YE ◽  
ZHIDONG GAO ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Gsk 3Β

ADRENAL VENOUS PLASMA CONCENTRATIONS OF 17-OH-PROGESTERONE AND URINARY PREGNANETRIOL EXCRETION IN 10 CASES OF ADRENOGENITAL SYNDROME

1965 ◽  
Vol 49 (3_Suppl) ◽  
pp. S62 ◽  
Author(s):  
B. Weinheimer ◽  
G. W. Oertel ◽  
W. Leppla ◽  
H. Blaise ◽  
L. Bette
Keyword(s):  
Plasma Concentrations ◽  
Adrenogenital Syndrome ◽  
Venous Plasma

Determinants of cardiac tyrosine hydroxylase activity during exercise-induced sympathetic activation in humans

1998 ◽  
Vol 274 (3) ◽  
pp. R626-R634 ◽  
Author(s):  
Graeme Eisenhofer ◽  
Bengt Rundqvist ◽  
Peter Friberg
Keyword(s):  
Tyrosine Hydroxylase ◽  
Plasma Concentrations ◽  
Sympathetic Nerves ◽  
Relative Increase ◽  
Sympathetic Activation ◽  
Storage Vesicles ◽  
Extended Range ◽  
Tyrosine Hydroxylation ◽  
Exercise Induced ◽  
Venous Plasma

This study assessed whether the mechanisms regulating cardiac norepinephrine (NE) synthesis with changes in NE release are influenced by functions of sympathetic nerves affecting transmitter turnover independently of transmitter release. Differences in arterial and coronary venous plasma concentrations of NE and its metabolites and of dihydroxyphenylalanine (DOPA), the immediate product of tyrosine hydroxylase (TH), were examined before and during cycling exercise. Relative increases during exercise in cardiac tyrosine hydroxylation (as reflected by the %increase in cardiac DOPA spillover) matched closely corresponding increases in NE turnover, but were much lower than increases in NE release. The much larger relative increases in release than turnover of NE were largely attributable to the extensive contribution to transmitter turnover from intraneuronal metabolism of NE leaking from storage vesicles. This contribution remains unchanged during sympathetic activation so that the relative increase in NE turnover is much smaller than that in exocytotic release of NE. To replenish the NE lost from stores during sympathetic activation, TH activity need increase only in proportion to the smaller increase in turnover rather than the larger relative increase in release. The ability to “gear down” increases in tyrosine hydroxylation relative to increases in NE release provides sympathetic nerves the capacity for a more extended range of sustainable release rates than otherwise possible.

Hypoxemia raises muscle sympathetic activity but not norepinephrine in resting humans

1989 ◽  
Vol 66 (4) ◽  
pp. 1736-1743 ◽  
Author(s):  
L. B. Rowell ◽  
D. G. Johnson ◽  
P. B. Chase ◽  
K. A. Comess ◽  
D. R. Seals
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Nervous Activity ◽  
Plasma Concentrations ◽  
Random Order ◽  
Sympathetic Nervous Activity ◽  
Severe Hypoxemia ◽  
Arterial Blood ◽  
End Tidal ◽  
Venous Plasma

The experimental objective was to determine whether moderate to severe hypoxemia increases skeletal muscle sympathetic nervous activity (MSNA) in resting humans without increasing venous plasma concentrations of norepinephrine (NE) and epinephrine (E). In nine healthy subjects (20–34 yr), we measured MSNA (peroneal nerve), venous plasma levels of NE and E, arterial blood pressure, heart rate, and end-tidal O2 and CO2 before (control) and during breathing of 1) 12% O2 for 20 min, 2) 10% O2 for 20 min, and 3) 8% O2 for 10 min--in random order. MSNA increased above control in five, six, and all nine subjects during 12, 10, and 8% O2, respectively (P less than 0.01), but only after delays of 12 (12% O2) and 4 min (8 and 10% O2). MSNA (total activity) rose 83 +/- 20, 260 +/- 146, and 298 +/- 109% (SE) above control by the final minute of breathing 12, 10, and 8% O2, respectively. NE did not rise above control at any level of hypoxemia; E rose slightly (P less than 0.05) at one time only with both 10 and 8% O2. Individual changes in MSNA during hypoxemia were unrelated to elevations in heart rate or decrements in blood pressure and end-tidal CO2--neither of which always fell. We conclude that in contrast to some other sympathoexcitatory stimuli such as exercise or cold stress, moderate to severe hypoxemia increases leg MSNA without raising plasma NE in resting humans.

Altered cardiovascular responsiveness to adrenoceptor agonists in endurance-trained men

1991 ◽  
Vol 70 (2) ◽  
pp. 531-538 ◽  
Author(s):  
J. Svedenhag ◽  
A. Martinsson ◽  
B. Ekblom ◽  
P. Hjemdahl
Keyword(s):  
Plasma Concentrations ◽  
Systolic Time Intervals ◽  
Trained Subjects ◽  
Binding Characteristics ◽  
Adrenoceptor Agonists ◽  
Blood Pressures ◽  
Systolic Time ◽  
Induced Changes ◽  
Trained Runners ◽  
Venous Plasma

The influence of physical training on responses to intravenous infusions of phenylephrine (Phe) and isoproterenol (Iso) were investigated in 10 well-trained runners (WT) and 10 age-matched untrained controls (UT). The latter were reinvestigated after a 4-mo training period. The venous plasma Iso and Phe concentrations attained during infusions were lower in WT than in UT. Responses were related to the corresponding plasma concentrations. Phe-induced decreases and Iso-induced increases in heart rate were less pronounced (P less than 0.01) in WT than in UT. At venous plasma concentrations of 100 nM Phe and 0.8 nM Iso, the responses were -9 +/- 1 and 30 +/- 2, and -17 +/- 2 and 44 +/- 4 beats/min, respectively. Increases in blood pressures during Phe infusions were greater in WT than in UT (100 nM Phe: systolic 36 +/- 3 vs. 25 +/- 3 mmHg, P less than 0.05). The Iso-induced decrease in diastolic blood pressure was also more pronounced in WT (0.8 nM Iso: -29 +/- 3 vs. -15 +/- 2 mmHg, P less than 0.01). Iso-induced changes in systolic time intervals showed no consistent differences between training states. Increases in plasma adenosine 3',5'-cyclic monophosphate during Iso infusions were smaller (P less than 0.05) in WT than in UT, whereas increases in plasma glycerol were larger (P less than 0.05). Lymphocyte beta 2-adrenoceptor function and binding characteristics did not differ between training states. In summary, the present results indicate that beta-adrenergic vasodilator and alpha-adrenergic vasopressor responses are enhanced in endurance-trained subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals The influence of preconditioning on metabolic changes in the pig liver before, during, and after warm liver ischemia measured by microdialysis

2008 ◽  
Vol 3 (1) ◽  
pp. 310-315 ◽  
Author(s):  
Anne-Sofie Kannerup ◽  
Henning Grønbæk ◽  
Peter Funch-Jensen ◽  
Rasmus Langelund Jørgensen ◽  
Frank Viborg Mortensen
Keyword(s):  
Metabolic Changes ◽  
Liver Ischemia ◽  
Pig Liver ◽  
Warm Liver Ischemia
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