Secretion of Parathyroid Hormone Oscillates Depending on the Change in Serum Ionized Calcium during Hemodialysis and May Affect Bone Metabolism

2005 ◽  
Vol 101 (1) ◽  
pp. c9-c17 ◽  
Author(s):  
Tokuyuki Kitahara ◽  
Kazue Ueki ◽  
Takashi Kuroiwa ◽  
Yoriaki Kaneko ◽  
Keiju Hiromura ◽  
...  
1993 ◽  
Vol 23 (3) ◽  
pp. 183-193 ◽  
Author(s):  
S. Minisola ◽  
M.T. Pacitti ◽  
A. Scarda ◽  
R. Rosso ◽  
E. Romagnoli ◽  
...  

1993 ◽  
Vol 234 (2) ◽  
pp. 195-200 ◽  
Author(s):  
M. RUDNICKI ◽  
J. THODE ◽  
T. JØRGENSEN ◽  
B. L. HEITMANN ◽  
O. H. SØRENSEN

2018 ◽  
Vol 33 (7) ◽  
pp. 1326-1334 ◽  
Author(s):  
Wendy M Kohrt ◽  
Sarah J Wherry ◽  
Pamela Wolfe ◽  
Vanessa D Sherk ◽  
Toby Wellington ◽  
...  

Author(s):  
Noran Jameel Ibraheem ◽  
Manar Muhammad Hasan Al-Murshidi ◽  
Walaa Saleh Hasan

Ionized calcium has a biological activity, this study has been debated whether the status of calcium homeostasis in correlated with anti-Mullerian hormone level how does influence the reproductive ability in some pre-menopausal women. The current study was conducted in the college of science for women during the period from February 2015 to May 2016, study population was involved eighty volunteer women (20-35) years enrolled in this study, fifty women with primary infertility considered as a study group, while the other 30 volunteers parous women considered as a control group. ELISA kit was used to assay the serum level of anti-Mullerian and parathyroid hormone, whereas colorimetric technique was applied to evaluate the total calcium, albumin, and inorganic phosphorus serum level, while ionized calcium is achieved by special equation depending on the total calcium and albumin level. Independent T-test analysis was applied to specify any significant variation for investigated parameters between control and study group, linear regression analyses were used to explore the association between ionized calcium and anti-Mullerian hormone (AMH) level in both control and infertile groups. The results revealed that infertile group have significantly (p<0.001) lower mean serum ionized calcium level(4.31±0.61mg/dl)than the control group(5.57±0.45mg/dl) accompanied by significantly (p<0.001) increase in parathyroid hormone level (49.2±32.2 ng/dl) in a study group in comparison with a control group whose reported (92.1±22.2ng/dl) mean concentration ,infertile women revealed significantly decrease mean level in anti-Mullerian hormone (2.59±1.38ng/d)  compared with  the control group (3.44±1.00ng/dl), linear regression analyses revealed a significant positive relation between's ionized calcium concentration and AMH level (r=0.58, p=0.000, n=40) in the control group, as well, there was a significant strong positive connection was seen between serum ionized calcium and AMH level for the infertile group (r=0.70, p=0.000, n=50),our conclusion suggested that any physiological process including reproductive ability may need in one way or another to balance in the availability of ionized calcium.


1999 ◽  
Vol 43 (6) ◽  
pp. 356-364 ◽  
Author(s):  
Ulla Teuri ◽  
Merja Kärkkäinen ◽  
Christel Lamberg-Allardt ◽  
Riitta Korpela

2014 ◽  
Vol 71 (6) ◽  
pp. 559-564 ◽  
Author(s):  
Danijela Radojkovic ◽  
Milica Pesic ◽  
Tatjana Ristic

Background/Aim. There is a lack of data on the effects of prolactin on calcium metabolism and bone turnover in hyperprolactinemia of various origins. The aim of this study was to compare the influence of medicamentous and physiological hyperprolactinemia on bone turnover in female rats. Methods. Experimental animals (18 weeks old, Wistar female rats) were divided as follows: the group P - 9 rats, 3 weeks pregnant; the group M3-10 rats that were intramuscularly administrated sulpirid (10 mg/kg) twice daily for 3 weeks, the group M6 - 10 rats that were intramuscularly administrated with sulpirid (10 mg/kg) twice daily for 6 weeks, and age matched nulliparous rats as the control group: 10 rats, 18-week-old (C1) and 7 rats, 24 weeks old (C2). Laboratory investigations included serum ionized calcium and phosphorus, urinary calcium and phosphorous excretion, osteocalcin and serum procollagen type 1 N-terminal propeptide (P1NP). Results. Experimental animals in the group P compared to the control group, displayed lower mean serum ionized calcium (0.5 ? 0.2 vs 1.12 ? 0.04 mmol/L; p < 0.001); higher mean serum phosphorus (2.42 ? 0.46 vs 2.05 ? 0.2 mmol/L; p < 0.05); increased urinary calcium (3.90 ? 0.46 vs 3.05 ? 0.58; p < 0.01) and significantly increased P1NP (489,22 ? 46,77 vs 361.9 ? 53,01 pg/mL; p < 0.001). Experimental animals in the group M3 had significantly decreased P1NP, compared to the control group. Prolongated medicamentous hyperprolactinemia (the group M6) induced increased serum ionized calcium (1.21 ? 0.03 vs 1.15 ? 0.02 mmol/L; p < 0.001); decreased serum phosphorus (1.70 ? 0.13 vs 1.89 ? 0.32 mmol/L; p < 0.001); decreased osteocalcin and P1NP. Conclusions. Physiological hyperprolactinemia does not have such harmful effect on bone metabolism as medicamentous hyperprolactinemia. Chronic medicamentous hyperprolactinemia produces lower serum levels of bone formation markers. Assessment of bone turnover markers in prolongated medicamentous hyperprolactinemia provides an opportunity for earlier diagnosis of bone metabolism disturbances and should be considered as mandatory.


Sign in / Sign up

Export Citation Format

Share Document