Co-Transplantation of Schwann Cells Promotes the Survival and Differentiation of Neural Stem Cells Transplanted into the Injured Spinal Cord

2005 ◽  
Vol 27 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Yuan-Shan Zeng ◽  
Ying Ding ◽  
Li-Zhi Wu ◽  
Jia-Song Guo ◽  
Hai-Biao Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Schwann Cells ◽  
Injured Spinal Cord

Inhibition of astrocytic differentiation of transplanted neural stem cells by chondroitin sulfate methacrylate hydrogels for the repair of injured spinal cord

2019 ◽  
Vol 7 (5) ◽  
pp. 1995-2008 ◽  
Author(s):  
Can Liu ◽  
Lei Fan ◽  
Jianghao Xing ◽  
Qiyou Wang ◽  
Chengkai Lin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Chondroitin Sulfate ◽  
Spinal Cord Injuries ◽  
Injured Spinal Cord ◽  
Astrocytic Differentiation ◽  
P Recovery

Recovery from spinal cord injuries after transplanted neural stem cells encapsulated in chondroitin sulfate methacrylate hydrogels.

Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

2007 ◽  
Vol 426 (2) ◽  
pp. 69-74 ◽  
Author(s):  
Hiroki Takeuchi ◽  
Atsushi Natsume ◽  
Toshihiko Wakabayashi ◽  
Chihiro Aoshima ◽  
Shinji Shimato ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Dependent Manner ◽  
Injured Spinal Cord ◽  
Human Neural Stem Cells ◽  
Adult Mice

scholarly journals Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injury

Spinal Cord ◽  
2006 ◽  
Vol 45 (1) ◽  
pp. 15-24 ◽  
Author(s):  
J-S Guo ◽  
Y-S Zeng ◽  
H-B Li ◽  
W-L Huang ◽  
R-Y Liu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Schwann Cells ◽  
Cord Injury

scholarly journals Transplantation of erythropoietin gene-modified neural stem cells improves the repair of injured spinal cord

2015 ◽  
Vol 10 (9) ◽  
pp. 1483 ◽  
Author(s):  
Rui Gu ◽  
Min-fei Wu ◽  
Shu-quan Zhang ◽  
Jia-bei Liu ◽  
Ye Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Injured Spinal Cord

scholarly journals In vivo conversion of rat astrocytes into neuronal cells through neural stem cells in injured spinal cord with a single zinc-finger transcription factor

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Masoumeh Zarei-Kheirabadi ◽  
Mahdi Hesaraki ◽  
Sahar Kiani ◽  
Hossein Baharvand
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Rating Scale ◽  
Injured Spinal Cord ◽  
Functional Impairments ◽  
Cord Injury ◽  
Rat Astrocytes

Abstract Background Spinal cord injury (SCI) results in glial scar formation and irreversible neuronal loss, which finally leads to functional impairments and long-term disability. Our previous studies have demonstrated that the ectopic expression of Zfp521 reprograms fibroblasts and astrocytes into induced neural stem cells (iNSCs). However, it remains unclear whether treatment with Zfp521 also affects endogenous astrocytes, thus promoting further functional recovery following SCI. Methods Rat astrocytes were transdifferentiated into neural stem cells in vitro by ZFP521 or Sox2. Then, ZFP521 was applied to the spinal cord injury site of a rat. Transduction, real-time PCR, immunohistofluorescence, and function assessments were performed at 6 weeks post-transduction to evaluate improvement and in vivo lineage reprogramming of astrocytes. Results Here, we show that Zfp521 is more efficient in reprogramming cultured astrocytes compared with Sox2. In the injured spinal cord of an adult rat, resident astrocytes can be reprogrammed into neurons through a progenitor stage by Zfp521. Importantly, this treatment improves the functional abilities of the rats as evaluated by the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale and further by calculation of its subscores. There was enhanced locomotor activity in the hind limbs, step length, toe spread, foot length, and paw area. In addition, motor evoked potential recordings demonstrated the functional integrity of the spinal cord. Conclusions These results have indicated that the generation of iNSCs or neurons from endogenous astrocytes by in situ reprogramming might be a potential strategy for SCI repair. Graphical abstract

Electro-Acupuncture Improves Survival and Migration of Transplanted Neural Stem Cells in Injured Spinal Cord in Rats

2008 ◽  
Vol 33 (1) ◽  
pp. 19-31 ◽  
Author(s):  
Ya-Yun Chen ◽  
Wei Zhang ◽  
Yu-Lin Chen ◽  
Shui-Jun Chen ◽  
Hongxin Dong ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Injured Spinal Cord ◽  
And Migration
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