Gene Therapy for Degenerative Disc Disease

2005 ◽  
pp. 37-51
Author(s):  
Joseph Kim ◽  
Lars G. Gilbertson ◽  
James D. Kang
Keyword(s):  
Gene Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc

scholarly journals Gene therapy for degenerative disc disease

Gene Therapy ◽  
2004 ◽  
Vol 11 (4) ◽  
pp. 390-401 ◽  
Author(s):  
S Sobajima ◽  
JS Kim ◽  
LG Gilbertson ◽  
JD Kang
Keyword(s):  
Gene Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc

Potential Use of Sox9 Gene Therapy for Intervertebral Degenerative Disc Disease

Spine ◽  
2003 ◽  
Vol 28 (8) ◽  
pp. 755-763 ◽  
Author(s):  
Ronjon Paul ◽  
Rex C. Haydon ◽  
Hongwei Cheng ◽  
Akira Ishikawa ◽  
Nikola Nenadovich ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Sox9 Gene ◽  
Potential Use

Mesenchymanl Stem Cell Based Intradiscal Gene Therapy: Therapeutic Implication in Degenerative Disc Disease

2004 ◽  
Vol 11 (2) ◽  
pp. 67
Author(s):  
Hyang Kim ◽  
Un-Hye Kwon ◽  
Kwang-Il Lee ◽  
Ki-Hong Song ◽  
Sung-Yeop Shin ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Degenerative Disc Disease ◽  
Therapeutic Implication ◽  
Disc Disease ◽  
Degenerative Disc

Hubungan Kadar Lipid Darah Dengan Degenerative Disc Disease Berdasarkan Klasifikasi Pfirrmann Menggunakan Magnetic Resonance Imaging Lumbosacral pada Pasien Nyeri Punggung Bawah

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Ryan Indra ◽  
Muhammad Ilyas ◽  
Mirna Muis ◽  
Bachtiar Murtala ◽  
Andi Alfian ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Degenerative Disc Disease ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Resonance Imaging ◽  
Disc Disease ◽  
Degenerative Disc

Penelitian ini bertujuan mengetahui hubungan serum lipid darah dengan degenerative disc disease berdasarkan klasifikasi pfirrmann menggunakan magnetic resonance imaging lumbosacral pada pasien nyeri punggung bawah. Penelitian ini dilaksanakan di Departemen Radiologi RS. Dr. Wahidin Sudirohusodo Makassar mulai bulan Oktober 2018 sampai Januari 2019. Subjek sebanyak 52 orang dengan rentang usia 30 - 60 tahun. Metode yang digunakan adalah uji Spearman. Hasil penelitian menunjukkan terdapat korelasi antara kadar low-density lipoprotein (LDL) dan trigliserida serum dengan degenerative disc disease dengan nilai p=0.02 (p0.05). Semakin tinggi kadar LDL dan trigliserida maka derajat degerative disc disease cendereng semakin berat. Tidak terdapat korelasi antara HDL dengan degenerative disc disease. Secara statistik tidak terdapat korelasi antara kolesterol total dengan degenerative disc disease. Namun, didapatkan pada grafik nilai kolesterol total pada setiap derajat degenerative disc disease meningkat.

Subclinical Infection and Disc Dysbiosis as a Cause of Degenerative Disc Disease and Low Back Pain

2020 ◽  
Author(s):  
S. Rajasekaran ◽  
S. Dilip Chand Raja ◽  
Chitraa Tangavel ◽  
M. Raveendran ◽  
K. S. Sri Vijay Anand ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Degenerative Disc Disease ◽  
Low Back ◽  
Subclinical Infection ◽  
Disc Disease ◽  
Degenerative Disc

Lumbar Fusion Surgery for Patients With Back Pain and Degenerative Disc Disease: An Observational Study From the Canadian Spine Outcomes and Research Network

2021 ◽  
pp. 219256822098547
Author(s):  
Nathan Evaniew ◽  
Ganesh Swamy ◽  
W. Bradley Jacobs ◽  
Jacques Bouchard ◽  
Roger Cho ◽  
...  
Keyword(s):  
Back Pain ◽  
Degenerative Disc Disease ◽  
Short Form ◽  
Lumbar Fusion ◽  
Research Network ◽  
Disc Disease ◽  
Fusion Surgery ◽  
Degenerative Disc ◽  
Lumbar Fusion Surgery ◽  
Related Quality

Study Design: Uncontrolled retrospective observational study. Objectives: Surgery for patients with back pain and degenerative disc disease is controversial, and studies to date have yielded conflicting results. We evaluated the effects of lumbar fusion surgery for patients with this indication in the Canadian Spine Outcomes and Research Network (CSORN). Methods: We analyzed data that were prospectively collected from consecutive patients at 11 centers between 2015 and 2019. Our primary outcome was change in patient-reported back pain at 12 months of follow-up, and our secondary outcomes were satisfaction, disability, health-related quality of life, and rates of adverse events. Results: Among 84 patients, we observed a statistically significant improvement of back pain at 12 months that exceeded the threshold of Minimum Clinically Important Difference (MCID) (mean change -3.7 points, SD 2.6, p < 0.001, MCID = 1.2; 77% achieved MCID), and 81% reported being “somewhat” or “extremely” satisfied. We also observed improvements of Oswestry Disability Index (-17.3, SD 16.6), Short Form-12 Physical Component Summary (10.3, SD 9.6) and Short Form-12 Mental Component Summary (3.1, SD 8.3); all p < 0.001). The overall rate of adverse events was 19%. Conclusions: Among a highly selective group of patients undergoing lumbar fusion surgery for degenerative disc disease, most experienced a clinically significant improvement of back pain as well as significant improvements of disability and health-related quality of life, with high satisfaction at 1 year of follow-up. These findings suggest that surgery for this indication may provide some benefit, and that further research is warranted.

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