Protective Effect of Intra-Rectal Administration of Rebamipide on Dextran Sulfate Sodium-Induced Rat Colitis

Digestion ◽  
2004 ◽  
Vol 70 (4) ◽  
pp. 240-249 ◽  
Author(s):  
Mitsuaki Okayama ◽  
Ryoichi Tsubouchi ◽  
Hikaru Nishio ◽  
Shinichi Kato ◽  
Koji Takeuchi
Keyword(s):  
Protective Effect ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Rectal Administration

Sa1102 PROTECTIVE EFFECT OF ALISMATIS RHIZOMA ON DEXTRAN SULFATE SODIUM-INDUCED COLITIS MICE MODEL

2020 ◽  
Vol 158 (6) ◽  
pp. S-276
Author(s):  
Seok-Jae Ko ◽  
Hyejin Joo ◽  
Youngmin Bu ◽  
Beom-Joon Lee ◽  
Soo-Ho Cho ◽  
...  
Keyword(s):  
Protective Effect ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Mice Model ◽  
Alismatis Rhizoma

Protective Effect of Lactulose on Dextran Sulfate Sodium-Induced Colonic Inflammation in Rats

2004 ◽  
Vol 49 (9) ◽  
pp. 1466-1472 ◽  
Author(s):  
György Rumi ◽  
Ryouichi Tsubouchi ◽  
Mitsuaki Okayama ◽  
Shinichi Kato ◽  
Gyula Mózsik ◽  
...  
Keyword(s):  
Protective Effect ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Colonic Inflammation

Protective effect of sugar cane extract against dextran sulfate sodium-induced colonic inflammation in mice

2017 ◽  
Vol 49 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Bin Wang ◽  
Yansen Li ◽  
Masami Mizu ◽  
Toma Furuta ◽  
ChunMei Li
Keyword(s):  
Protective Effect ◽  
Sugar Cane ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Colonic Inflammation

PACAP and Its Receptor, PAC1 Exert a Protective Effect in Preventing Dextran Sulfate Sodium (DSS)-Induced Colitis

2005 ◽  
Vol 100 ◽  
pp. S308-S309
Author(s):  
Patrizia Germano ◽  
Sandy Lieu ◽  
Mulugeta Million ◽  
David Oh ◽  
James Waschek ◽  
...  
Keyword(s):  
Protective Effect ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium

scholarly journals EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Xue Bing ◽  
Liu Xuelei ◽  
Dong Wanwei ◽  
Liang Linlang ◽  
Chen Keyan
Keyword(s):  
Ulcerative Colitis ◽  
Flow Cytometry ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Activity Index ◽  
Mucosal Injury ◽  
Inflammatory Factors ◽  
Intestinal Mucosal Injury

Objective. To observe the protective effect of epigallocatechin gallate (EGCG) on dextran sulfate sodium- (DSS-) induced ulcerative colitis in rats and to explore the roles of TLR4/MyD88/NF-κB signaling pathway. Methods. Rat models of ulcerative colitis were established by giving DSS. EGCG (50 mg/kg/d) was given to assess disease activity index. HE staining was applied to observe histological changes. ELISA and qPCR detected the expression of inflammatory factors. Flow cytometry was used to measure the percentage of CD4+IFN-γ+ and CD4+IL-4+ in the spleen and colon. TLR4 antagonist E5564 was given in each group. Flow cytometry was utilized to detect CD4+IFN-γ+ and CD4+IL-4+ cells. Immunohistochemistry, qPCR, and western blot assay were applied to measure the expression of TLR4, MyD88, and NF-κB. Results. EGCG improved the intestinal mucosal injury in rats, inhibited production of inflammatory factors, maintained the balance of Th1/Th2, and reduced the expression of TLR4, MyD88, and NF-κB. After TLR4 antagonism, the protective effect of EGCG on intestinal mucosal injury was weakened in rats with ulcerative colitis, and the expressions of inflammatory factors were upregulated. Conclusion. EGCG can inhibit the intestinal inflammatory response by reducing the severity of ulcerative colitis and maintaining the Th1/Th2 balance through the TLR4/MyD88/NF-κB signaling pathway.

Sign in / Sign up

Export Citation Format

Share Document