Mortality and Cause of Death after Hospital Discharge in 10,981 Patients with Ischemic Stroke and Transient Ischemic Attack

2005 ◽  
Vol 19 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Kazumi Kimura ◽  
Kazuo Minematsu ◽  
Seiji Kazui ◽  
Takenori Yamaguchi
Stroke ◽  
2021 ◽  
Author(s):  
Jennifer L. Dearborn-Tomazos ◽  
Xin Hu ◽  
Dawn M. Bravata ◽  
Manali A. Phadke ◽  
Fitsum M. Baye ◽  
...  

Background and Purpose: Practice guidelines recommend that most patients receive moderate- or high-potency statins after ischemic stroke or transient ischemic attack (TIA) of atherosclerotic origin. We tested the association of different patterns of potency for prescribed statin therapy—assessed before admission and at hospital discharge for ischemic stroke or TIA—on mortality in a large, nationwide sample of US Veterans. Methods: The study population included patients with an ischemic stroke or TIA occurring during 2011 at any of the 134 Veterans Health Administration facilities. We used electronic outpatient pharmacy files to identify statin dose at hospital admission and within 7 days after hospital discharge. We categorized statin dosing as low, moderate, or high potency; moderate or high potency was considered at goal. We created 6 mutually exclusive groups to reflect patterns of statin potency from hospital admission to discharge: goal to goal, low to goal, goal to low or goal to none (deintensification), none to none, none to low, and low to low. We used logistic regression to compare 30-day and 1-year mortality across statin potency groups. Results: The population included 9380 predominately White (71.1%) men (96.3%) who were hospitalized for stroke or TIA. In this sample, 34.1% of patients (n=3194) were discharged off a statin medication. Deintensification occurred in 14.0% of patients (n=1312) and none to none in 20.5% (n=1924). Deintensification and none to none were associated with a higher odds of mortality as compared with goal to goal (adjusted odds ratio 1-year mortality: deintensification versus goal to goal, 1.26 [95% CI, 1.02–1.57]; none to none versus goal to goal, 1.59 [95% CI, 1.30–1.93]). Adjustments for differences in baseline characteristics using propensity weighted scores demonstrated similar results. Conclusions: Underutilization of statins, including no treatment or underdosing after stroke (deintensification), was observed in approximately one-third of veterans with ischemic stroke or TIA and was associated with higher mortality when compared with patients who were at goal for statin prescription dosing.


2021 ◽  
pp. 383-398
Author(s):  
Kelly D. Flemming

Ischemic stroke is the fifth leading cause of death and a major condition feared by older adults. Clinical identification of patients with cerebral ischemia is important to provide appropriate, immediate treatment and initiate stroke preventive strategies. This chapter presents an overview of the more common causes and mechanisms of stroke. Ischemic stroke has been classically defined as a fixed focal neurologic deficit attributable to an arterial or venous territory and lasting longer than 24 hours. Transient ischemic attack has been classically defined as a transient focal neurologic deficit attributable to an arterial territory lasting less than 24 hours.


Author(s):  
Nanxiang Ouyang ◽  
Chuning Shi ◽  
Xiaofan Guo ◽  
Yihan Chen ◽  
Yingxian Sun

CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 102S
Author(s):  
Kaushang Gandhi ◽  
Wilbert S. Aronow ◽  
Chandrasekar Palaniswamy ◽  
Harshad Amin ◽  
Harit Desai ◽  
...  

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