C-106T Polymorphism in Promoter of Aldose Reductase Gene Is a Risk Factor for Diabetic Nephropathy in Type 2 Diabetes Patients with Poor Glycaemic Control

2005 ◽  
Vol 99 (3) ◽  
pp. e63-e67 ◽  
Author(s):  
Katarzyna Gosek ◽  
Dariusz Moczulski ◽  
Ewa Zukowska-Szczechowska ◽  
Wladyslaw Grzeszczak
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Diabetic Nephropathy ◽  
Glycaemic Control ◽  
Aldose Reductase ◽  
Poor Glycaemic Control ◽  
Reductase Gene ◽  
Diabetes Patients

scholarly journals INTEGRA study protocol: primary care intervention in type 2 diabetes patients with poor glycaemic control

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Àngels Molló ◽  
Anna Berenguera ◽  
Esther Rubinat ◽  
Bogdan Vlacho ◽  
Manel Mata ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Primary Care ◽  
Glycaemic Control ◽  
Study Protocol ◽  
Poor Glycaemic Control ◽  
Care Intervention ◽  
Diabetes Patients

scholarly journals Prevalence and determinants of poor glycaemic control: a cross-sectional study among Moroccan type 2 diabetes patients

2020 ◽  
Author(s):  
Ahmed Chetoui ◽  
Kamal Kaoutar ◽  
Soufiane Elmoussaoui ◽  
Kaltoum Boutahar ◽  
Abdesslam El Kardoudi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Hba1c Level ◽  
Associated Factors ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Poor Glycaemic Control ◽  
Duration Of Diabetes ◽  
Diabetes Patients

Abstract Background Diabetes remains poorly controlled in a high proportion of diabetes patients. This study examines the prevalence of poor glycaemic control and associated factors in type 2 diabetes patients in the Beni-Mellal Khenifra region in Morocco. Methods A cross-sectional survey was conducted in 2017 among 1456 diabetes patients attending primary health centres. Demographic and clinical data were collected through face-to-face interviews using structured and pre-tested questionnaires. Anthropometric measurements, including body weight, height and waist circumference were taken using standardized techniques and calibrated equipment. Glycaemic control was assessed in terms of the glycated haemoglobin (HbA1c) level and poor glycaemic control was defined as HbA1c ≥7% and a level <7% reflects good glycaemic control. Results Of the total participants, 66.3% had poor glycaemic control. Bivariate analysis showed that sex (p=0.010), education level (p=0.013), body mass index (p=0.048), duration of diabetes (p<0.0001) and type of therapeutic regimen (p<0.0001) were significantly associated with HbA1c level. However, multiple logistic regression analyses revealed that only a longer duration of diabetes (OR 1.525 [95% confidence interval {CI} 1.183–1.967], p=0.001) and receiving insulin therapy alone (OR 1.589 [95% CI 1.157–2.183], p=0.004) or a combination of oral antidiabetics with insulin (OR 2.554 [95% CI 1.786–3.653], p<0.001) were significantly associated with inadequate glycaemic control. Conclusions Despite the particularities of the region, the findings about glycaemic control and its cross-sectionally associated factors are in line with findings from other regions of Morocco. In this subgroup, the longer duration of diabetes and insulin treatment could constitute a cause leading to poor glycaemic control. However, inverse causality cannot be excluded.

Analysis of the association between diabetic nephropathy and polymorphisms in the aldose reductase gene in Type 1 and Type 2 diabetes mellitus

2001 ◽  
Vol 18 (11) ◽  
pp. 906-914 ◽  
Author(s):  
M. Neamat-Allah ◽  
S. A. Feeney ◽  
D. A. Savage ◽  
A. P. Maxwell ◽  
R. L. Hanson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Aldose Reductase ◽  
Reductase Gene

scholarly journals Prevalence of microalbuminuria among adults with Type 2 Diabetes mellitus at OOUTH, Sagamu

2018 ◽  
Vol 4 (1) ◽  
pp. 15-21
Author(s):  
Adebayo Adetola Amballi ◽  
Olatunde Odusan ◽  
Omobola Abioye Ogundahunsi ◽  
Alfred Ademola Jaiyesimi ◽  
Sunday Kolawole Oritogun ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Glycaemic Control ◽  
Plasma Glucose ◽  
Control Group ◽  
Poor Glycaemic Control ◽  
Diabetic Population

Background: Diabetes mellitus is a serious global epidemic. The menace of this chronic disease is attributable to its chronic complications which threaten both the world economy and life expectancy, especially in Sub- Saharan Africa. Nephropathy is a complication of Diabetes mellitus and a leading cause of End Stage Renal Disease. Objectives: To determine the prevalence of microalbuminuria as well as the effects of co-morbidities on the pattern of microalbuminuria among adults with Type 2 Diabetes mellitus.  Methods: A total of 325 adults with Diabetes mellitus and 100 controls without Diabetes mellitus were studied. The subjects with diabetes were classified into four groups ([i] diabetes only, [ii] diabetes with hypertension, [iii] diabetes with obesity and [iv] diabetes with hypertension and obesity). Urinary protein, microalbuminuria, fasting plasma glucose and Glycated Haemoglobin (HbA1c) were measured using standard methods. Results: The overall prevalence of microalbuminuria was 35.1% in the diabetic population compared to 8.0% in the control group. The prevalence of microalbuminuria in the various diabetic subgroups were as follows: 30.3% (diabetes only), 43.1% (diabetes with hypertension), 37.0% (diabetes with obesity) and 44.6% (diabetes with hypertension and obesity). The fasting plasma glucose and HbA1c were statistically significantly higher in the diabetic population than the control group. This indicated that there is a poor glycaemic control in the diabetic population and hence a possible cause of diabetic nephropathy. Conclusion: The risk of diabetic nephropathy was significant in the study population. The presence of one or more co-morbidities and poor glycaemic control increased the occurrence of diabetic nephropathy.

Sign in / Sign up

Export Citation Format

Share Document