Oral Adsorbent Prevents Reduction of Anionic Sites of the Glomerular Basement Membrane in Diabetic Nephropathy

2004 ◽  
Vol 99 (2) ◽  
pp. e56-e62 ◽  
Author(s):  
Kazuyoshi Okada ◽  
Koichi Matsumoto ◽  
Susumu Takahashi
Keyword(s):  
Diabetic Nephropathy ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Anionic Sites ◽  
Oral Adsorbent

scholarly journals Reduction of heparan sulphate-associated anionic sites in the glomerular basement membrane of rats with streptozotocin-induced diabetic nephropathy

Diabetologia ◽  
1995 ◽  
Vol 38 (10) ◽  
pp. 1169-1175 ◽  
Author(s):  
J. H. M. Berden ◽  
J. van den Born ◽  
A. A. van Kraats ◽  
M. A. H. Bakker ◽  
K. J. M. Assmann ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Heparan Sulphate ◽  
Anionic Sites

scholarly journals Reduction of heparan sulphate-associated anionic sites in the glomerular basement membrane of rats with streptozotocin-induced diabetic nephropathy

Diabetologia ◽  
1995 ◽  
Vol 38 (10) ◽  
pp. 1169-1175 ◽  
Author(s):  
J. van den Born ◽  
A. A. van Kraats ◽  
M. A. H. Bakker ◽  
K. J. M. Assmann ◽  
H. B. P. M. Dijkman ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Heparan Sulphate ◽  
Anionic Sites

scholarly journals Recovery of Anionic Sites of the Glomerular Basement Membrane after Their Disappearance by the Cationic Probe Molecule

Nephron ◽  
1991 ◽  
Vol 59 (3) ◽  
pp. 500-501 ◽  
Author(s):  
Ashio Yoshimura ◽  
Terukuni Ideura ◽  
Kiyoko Nakano ◽  
Hiroaki Oniki ◽  
Yuichi Sugisaki ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Probe Molecule ◽  
Anionic Sites

scholarly journals Recombinant lnterleukin-2 Alone Did Not Induce Proteinuria with Changes in Anionic Sites of the Glomerular Basement Membrane in Rats

Nephron ◽  
1992 ◽  
Vol 61 (1) ◽  
pp. 117-118
Author(s):  
Shouichi Fujimoto ◽  
Yoshitaka Yamamoto ◽  
Shuichi Hisanaga ◽  
Naoto Yokota ◽  
Tanenao Eto
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Anionic Sites

Temporary effects of circulating Amadori products on glomerular filtration properties in the normal mouse

2001 ◽  
Vol 280 (1) ◽  
pp. F103-F111 ◽  
Author(s):  
I. Londoño ◽  
M. Bendayan
Keyword(s):  
Diabetic Nephropathy ◽  
Basement Membrane ◽  
Glomerular Filtration ◽  
Glomerular Basement Membrane ◽  
Normal Mouse ◽  
Early Diabetes ◽  
Amadori Products ◽  
Time Points ◽  
Glycated Proteins ◽  
Filtration Properties

Previous studies have established a preferential glomerular filtration of glycated BSA (gBSA), as well as a facilitated filtration of BSA in the presence of gBSA. We intend to determine whether these modifications are permanent or transitory. gBSA was intravenously injected into anesthetized normal mice and maintained in circulation for 30 min, 1, 2, 24, and 48 h. Five minutes before death, FITC-BSA was injected. On immunocytochemical evaluations, increased glomerular filtration of FITC-BSA was found at all circulating time points. Changes at 24 and 48 h were less pronounced. Glomerular basement membrane (GBM)-to-lumen gBSA labeling ratios were similar at all time points suggesting no accumulation of gBSA in the GBM. Seventy percent of the gBSA was cleared from the circulation and the GBM after 24 h, and 95% after 48 h. This was confirmed in experiments with radiolabeled tracers. These results suggest that the alteration in GBM permeability to BSA in the normal mouse are due to the presence of gBSA and are gradually overcome along with its clearance from circulation. In early diabetes, increasing concentrations of circulating glycated proteins could be responsible for changes in glomerular permselectivity and probably for the alteration in glomerular filtration properties leading to diabetic nephropathy.

Abnormal Distribution of Anionic Sites in the Glomerular Basement Membrane in Glomerulonephritis of Dogs Infected with Dirofilaria immitis.

2000 ◽  
Vol 62 (11) ◽  
pp. 1193-1195 ◽  
Author(s):  
Junichi KAMIIE ◽  
Kinji SHIROTA ◽  
Munetaka YAMAKI ◽  
Hitoshi KITAGAWA ◽  
Masahiko WASAKI ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Glomerular Basement Membrane ◽  
Dirofilaria Immitis ◽  
Anionic Sites ◽  
Abnormal Distribution
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