High Sustained Virologic Response Rate after Interferon Monotherapy in Japanese Hepatitis C Patients with a Low HCV RNA Titer and/or HCV Genotype 2

Intervirology ◽  
2004 ◽  
Vol 47 (6) ◽  
pp. 328-334 ◽  
Author(s):  
Osamu Yokosuka ◽  
Shosuke Iwama ◽  
Noriaki Suzuki ◽  
Motohide Takashi ◽  
Yasuo Hirai ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Response Rate ◽  
Virologic Response ◽  
Sustained Virologic Response Rate ◽  
Hcv Rna ◽  
Interferon Monotherapy ◽  
Genotype 2 ◽  
Hcv Genotype 2 ◽  
High Sustained Virologic Response ◽  
Virologic Response Rate

scholarly journals Treatment outcomes of patients with chronic hepatitis C receiving sofosbuvir-based combination therapy within national hepatitis C elimination program in the country of Georgia

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tengiz Tsertsvadze ◽  
Amiran Gamkrelidze ◽  
Muazzam Nasrullah ◽  
Lali Sharvadze ◽  
Juliette Morgan ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Response Rate ◽  
Response Rates ◽  
Pegylated Interferon ◽  
Virologic Response ◽  
Hcv Rna ◽  
Genotype 3 ◽  
Treatment Regimens ◽  
Genotype 2 ◽  
Chronic Hcv

Abstract Background Georgia has one of the highest HCV prevalence in the world and launched the world’s first national HCV elimination programs in 2015. Georgia set the ambitious target of diagnosing 90% of people living with HCV, treating 95% of those diagnosed and curing 95% of treated patients by 2020. We report outcomes of Sofosbuvir (SOF) based treatment regimens in patients with chronic HCV infection in Georgia. Methods Patients with cirrhosis, advanced liver fibrosis and severe extrahepatic manifestations were enrolled in the treatment program. Initial treatment consisted of SOF plus ribavirin (RBV) with or without pegylated interferon (INF). Sustained virologic response (SVR) was defined as undetectable HCV RNA at least 12 weeks after the end of treatment. SVR were calculated using both per-protocol and modified intent-to-treat (mITT) analysis. Results for patients who completed treatment through 31 October 2018 were analyzed. Results Of the 7342 patients who initiated treatment with SOF-based regimens, 5079 patients were tested for SVR. Total SVR rate was 82.1% in per-protocol analysis and 74.5% in mITT analysis. The lowest response rate was observed among genotype 1 patients (69.5%), intermediate response rate was achieved in genotype 2 patients (81.4%), while the highest response rate was among genotype 3 patients (91.8%). Overall, SOF/RBV regimens achieved lower response rates than IFN/SOF/RBV regimen (72.1% vs 91.3%, P < 0.0001). In multivariate analysis being infected with HCV genotype 2 (RR =1.10, CI [1.05–1.15]) and genotype 3 (RR = 1.14, CI [1.11–1.18]) were associated with higher SVR. Patients with cirrhosis (RR = 0.95, CI [0.93–0.98]), receiving treatment regimens of SOF/RBV 12 weeks, SOF/RBV 20 weeks, SOF/RBV 24 weeks and SOF/RBV 48 weeks (RR = 0.85, CI [0.81–0.91]; RR = 0.86, CI [0.82–0.92]; RR = 0.88, CI [0.85–0.91] and RR = 0.92, CI [0.87–0.98], respectively) were less likely to achieve SVR. Conclusions Georgia’s real world experience resulted in high overall response rates given that most patients had severe liver damage. Our results provide clear evidence that SOF plus IFN and RBV for 12 weeks can be considered a treatment option for eligible patients with all three HCV genotypes. With introduction of next generation DAAs, significantly improved response rates are expected, paving the way for Georgia to achieve HCV elimination goals.

CP-007 Hepatitis c virus treatment-related anaemia and its association with higher sustained virologic response rate

2015 ◽  
Vol 22 (Suppl 1) ◽  
pp. A3.2-A3
Author(s):  
R López-Sepúlveda ◽  
C García-Collado ◽  
J Pérez-Morales ◽  
CM Valencia Soto ◽  
FJ Orantes ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sustained Virologic Response ◽  
Response Rate ◽  
Virologic Response ◽  
Sustained Virologic Response Rate ◽  
Virologic Response Rate

Hepatitis C Virus Treatment-Related Anemia Is Associated With Higher Sustained Virologic Response Rate

2010 ◽  
Vol 139 (5) ◽  
pp. 1602-1611.e1 ◽  
Author(s):  
Mark S. Sulkowski ◽  
Mitchell L. Shiffman ◽  
Nezam H. Afdhal ◽  
K. Rajender Reddy ◽  
Jonathan McCone ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sustained Virologic Response ◽  
Response Rate ◽  
Virologic Response ◽  
Sustained Virologic Response Rate ◽  
Virologic Response Rate
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