Insulin-Like Growth Factors as Diagnostic Tools in Growth Hormone Deficiency during Childhood and Adolescence: The KIGS Experience

2004 ◽  
Vol 62 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Michael B. Ranke ◽  
Roland Schweizer ◽  
Anders Lindberg ◽  
David A. Price ◽  
Edward O. Reiter ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Diagnostic Tools ◽  
Childhood And Adolescence ◽  
Insulin Like Growth Factors

scholarly journals Isolated Growth Hormone Deficiency (GHD) in Childhood and Adolescence: Recent Advances

2014 ◽  
Vol 35 (3) ◽  
pp. 376-432 ◽  
Author(s):  
Kyriaki S. Alatzoglou ◽  
Emma Alice Webb ◽  
Paul Le Tissier ◽  
Mehul T Dattani
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Childhood And Adolescence ◽  
Isolated Growth Hormone Deficiency ◽  
Recent Advances

scholarly journals Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence

2015 ◽  
Vol 101 (1) ◽  
pp. 96-100 ◽  
Author(s):  
P G Murray ◽  
M T Dattani ◽  
P E Clayton
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Childhood And Adolescence ◽  
Supporting Evidence ◽  
Diagnosis And Management ◽  
False Positive Diagnosis ◽  
Starting Dose ◽  
Igf I ◽  
Stimulation Tests

Growth hormone deficiency (GHD) is a rare but important cause of short stature in childhood with a prevalence of 1 in 4000. The diagnosis is currently based on an assessment of auxology along with supporting evidence from biochemical and neuroradiological studies. There are significant controversies in the diagnosis and management of GHD. Growth hormone (GH) stimulation tests continue to play a key role in GHD diagnosis but the measured GH concentration can vary significantly with stimulation test and GH assay used, creating difficulties for diagnostic accuracy. Such issues along with the use of adjunct biochemical markers such as IGF-I and IGFBP-3 for the diagnosis of GHD, will be discussed in this review. Additionally, the treatment of GHD remains a source of much debate; there is no consensus on the best mechanism for determining the starting dose of GH in patients with GHD. Weight and prediction based models will be discussed along with different mechanisms for dose adjustment during treatment (auxology or IGF-I targeting approaches). At the end of growth and childhood treatment, many subjects diagnosed with isolated GHD re-test normal. It is not clear if this represents a form of transient GHD or a false positive diagnosis during childhood. Given the difficulties inherent in the diagnosis of GHD, an early reassessment of the diagnosis in those who respond poorly to GH is to be recommended.

Sign in / Sign up

Export Citation Format

Share Document