Effects of Dexamethasone, All-Trans Retinoic Acid, Vitamin D3 and Interferon-α on FO Myeloma Cells

Chemotherapy ◽  
2004 ◽  
Vol 50 (4) ◽  
pp. 190-193 ◽  
Author(s):  
Feyyaz Ozdemir ◽  
Nilgun Esen ◽  
Ercument Ovali ◽  
Yavuz Tekelioglu ◽  
Mustafa Yilmaz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Retinoic Acid ◽  
Interferon Α ◽  
Myeloma Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab

Leukemia ◽  
2015 ◽  
Vol 29 (10) ◽  
pp. 2039-2049 ◽  
Author(s):  
I S Nijhof ◽  
R W J Groen ◽  
H M Lokhorst ◽  
B van Kessel ◽  
A C Bloem ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Retinoic Acid ◽  
Myeloma Cells ◽  
Cd38 Expression ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Inhibition of myeloma cell growth by dexamethasone and all-trans retinoic acid: synergy through modulation of interleukin-6 autocrine loop at multiple sites

Blood ◽  
1996 ◽  
Vol 87 (1) ◽  
pp. 314-323 ◽  
Author(s):  
YH Chen ◽  
P Desai ◽  
RT Shiao ◽  
D Lavelle ◽  
A Haleem ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Cell Growth ◽  
Mrna Expression ◽  
Interleukin 6 ◽  
Growth Regulation ◽  
Myeloma Cell ◽  
Myeloma Cells ◽  
Trans Retinoic Acid ◽  
Clonogenic Growth ◽  
All Trans Retinoic Acid

Abstract Interleukin-6 (IL-6)/IL-6 receptor (IL-6R) plays a major role in autocrine/paracrine growth regulation of myeloma cells. We investigated the effect of dexamethasone and all-trans retinoic acid, previously shown to modulate IL-6/IL-6R, on the in vitro growth of a human myeloma cell line, OPM-2. Both agents inhibited the clonogenic growth and 3H- thymidine incorporation in a concentration-dependent fashion. Isobologram and median effect analysis showed a strong synergy between these two agents with a combination index in the range of 0.2 to 0.6. Both agents decreased the labeling index and the cell fraction in S and G2/M phases, suggesting a block in G1-S phase transition. The clonogenic growth was stimulated by exogenous IL-6 and was inhibited by monoclonal antibody to IL-6, suggesting an autocrine function of IL-6. The effect of dexamethasone but not all-trans retinoic acid was completely reversed by exogenous IL-6. Dexamethasone increased, while all-trans retinoic acid reduced, IL-6R but not gp130 mRNA expression. Their combination caused a net reduction in IL-6R mRNA. Cellular IL-6R density was altered correspondingly without changes in the binding affinity. IL-6 mRNA expression was reduced by dexamethasone and the combination, but was not affected by retinoic acid alone. However, IL-6 secretion into culture supernatant was abolished by both agents. A survey of 4 additional human myeloma cells showed that 1 was sensitive to both, 1 was sensitive to one agent only, and 2 were resistant to both. The study demonstrates the possibility of regulating myeloma cell growth through modulation of IL-6/IL-6R autocrine/paracrine loop and the principle of achieving a synergistic effect by blocking this loop at multiple sites.

scholarly journals Interleukin 10 abolishes the growth inhibitory effects of all-trans retinoic acid on human myeloma cells

2002 ◽  
Vol 116 (4) ◽  
pp. 787-795 ◽  
Author(s):  
Takemi Otsuki ◽  
Kenichiro Yata ◽  
Haruko Sakaguchi ◽  
Junichi Kurebayashi ◽  
Yoshinobu Matsuo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Interleukin 10 ◽  
Inhibitory Effects ◽  
Myeloma Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Growth Inhibitory ◽  
Human Myeloma Cells

scholarly journals All-trans retinoic acid and interferon-α in the treatment of a patient with resistant metastatic osteosarcoma

Cancer ◽  
2000 ◽  
Vol 89 (12) ◽  
pp. 2661-2666 ◽  
Author(s):  
Alessandra Todesco ◽  
Modesto Carli ◽  
Isabella Iacona ◽  
Emanuela Frascella ◽  
Vito Ninfo ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Interferon Α ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Metastatic Osteosarcoma

Rhabdomyomatous differentiation in primary Wilms tumor and hepatic metastases after chemotherapy and all-trans-retinoic acid in combination with interferon-α

2011 ◽  
Vol 57 (4) ◽  
pp. 698-699
Author(s):  
Yu-Hua Chao ◽  
Han-Ping Wu ◽  
I-Ping Chiang ◽  
Ching-Tien Peng ◽  
Yung-Li Yang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Wilms Tumor ◽  
Hepatic Metastases ◽  
Interferon Α ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0188887 ◽  
Author(s):  
Jamie M. Ahrens ◽  
James D. Jones ◽  
Nirca J. Nieves ◽  
Ann M. Mitzey ◽  
Hector F. DeLuca ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vitamin D ◽  
Retinoic Acid ◽  
Growth Factor ◽  
Mouse Skin ◽  
Factor Gene ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Growth Factor Gene ◽  
Rhino Mouse
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