Age-Dependent Telomere Attrition as a Potential Indicator of Racial Differences in Renal Growth Patterns

2004 ◽  
Vol 98 (3) ◽  
pp. e82-e88 ◽  
Author(s):  
L. Tchakmakjian ◽  
J.P. Gardner ◽  
P.D. Wilson ◽  
M. Kimura ◽  
J. Skurnick ◽  
...  
Keyword(s):  
Racial Differences ◽  
Growth Patterns ◽  
Renal Growth ◽  
Telomere Attrition ◽  
Age Dependent ◽  
Potential Indicator

scholarly journals Racial Differences in Growth Patterns of Children Assessed on the Basis of Bone Age

Radiology ◽  
2009 ◽  
Vol 250 (1) ◽  
pp. 228-235 ◽  
Author(s):  
Aifeng Zhang ◽  
James W. Sayre ◽  
Linda Vachon ◽  
Brent J. Liu ◽  
H. K. Huang
Keyword(s):  
Racial Differences ◽  
Bone Age ◽  
Growth Patterns

scholarly journals Age-dependent characteristics of compensatory renal growth

1975 ◽  
Vol 8 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Joel M. Kaufman ◽  
Robert Hardy ◽  
John P. Hayslett
Keyword(s):  
Renal Growth ◽  
Compensatory Renal Growth ◽  
Age Dependent

scholarly journals Telomere length and age-dependent telomere attrition: the blood-and-muscle model

2019 ◽  
Vol 97 (4) ◽  
pp. 328-334 ◽  
Author(s):  
Mirna N. Chahine ◽  
Simon Toupance ◽  
Sandy El-Hakim ◽  
Carlos Labat ◽  
Sylvie Gautier ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Telomere Length ◽  
Cross Sectional Study ◽  
Muscle Model ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional ◽  
Telomere Attrition ◽  
Age Related ◽  
Age Dependent ◽  
Muscle Biopsies

Short telomere length (TL) is associated with atherosclerotic cardiovascular disease (ACVD) and other age-related diseases. It is unclear whether these associations originate from having inherently short TL or a faster TL attrition before or during disease development. We proposed the blood-and-muscle model to assess TL dynamics throughout life course. Our objective was to measure TL in leukocytes (LTL) and in skeletal muscle (MTL), which served as a proxy of TL at birth. The delta (MTL–LTL) represented life-long telomere attrition. Blood draws and skeletal muscle biopsies were performed on 35 Lebanese individuals undergoing surgery. Following DNA extraction, LTL and MTL were measured by Southern blot. In every individual aged between 30 and 85 years, MTL was longer than LTL. With age, MTL and LTL decreased, but the delta (MTL–LTL) increased by 14 bp/year. We validated the blood-and-muscle model that allowed us to identify TL, TL at birth, and lifelong TL attrition in a cross-sectional study. This model can be used in larger cross-sectional studies to evaluate the association of telomere dynamics with age-related diseases onset and progression.

scholarly journals Telomere Length and the Transition to Family Caregiving in the REGARDS Study

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 818-819
Author(s):  
William Haley ◽  
Nicole Armstrong ◽  
Ryan Irvin ◽  
Marcela Blinka ◽  
Rasika Mathias ◽  
...  
Keyword(s):  
Socioeconomic Factors ◽  
Telomere Length ◽  
Racial Differences ◽  
Well Being ◽  
Length Change ◽  
Single Copy ◽  
Adverse Outcomes ◽  
Telomere Attrition ◽  
Age Related ◽  
Regards Study

Abstract An increase in life expectancy and an aging population has resulted in increased risks and prevalence of age-related diseases. Previous studies have shown that factors, such as chronic stress, are associated with shorter telomere length. When telomeres become critically short, cells enter a state of senescence, which is a hallmark of aging. Several prior studies examining the relationship between caregiving and telomere length have reported mixed results. The present study utilized data from the Caregiving Transitions Study, an ancillary study to the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. The difference in telomere length across an average ~8.6 years was compared between 235 incident caregivers and 229 controls. Telomere length was determined using the qPCR telomere-to-single copy gene (IFNB1) ratio (T/S) for each participant at both baseline and follow-up timepoints. Regression models controlling for age, sex, race, and baseline telomere length examined the association between caregiving status (exposure) and the telomere length change (□T/S). Sensitivity models adjusted for potential lifestyle and socioeconomic factors, including income, education, BMI, cigarette smoking, and alcohol use. We did not observe a significant association between □T/S and caregiving (beta=0.041, p=0.615). Adding lifestyle and socioeconomic factors did not change the null relationship (beta=0.062, p=0.455). In conclusion, this study provides evidence against an association between caregiving and the change in telomere length. Ultimately, more research to address the complex relationship between caregiving and telomere attrition is needed in order to prevent or reduce adverse outcomes and improve the well-being of caregivers and care recipients.

5.5 AGE-DEPENDENT TELOMERE ATTRITION, SHORT TELOMERES AND ATHEROSCLEROSIS

2016 ◽  
Vol 16 (C) ◽  
pp. 57
Author(s):  
Simon Toupance ◽  
Anna Kearney-Schwartz ◽  
Mohamed Temmar ◽  
Cécile Lakomy ◽  
Carlos Labat ◽  
...  
Keyword(s):  
Telomere Attrition ◽  
Age Dependent

scholarly journals Survival of Newly Founded Businesses: The Post-Entry Performance

1998 ◽  
Vol 37 (4II) ◽  
pp. 577-594 ◽  
Author(s):  
Talat Mahmood
Keyword(s):  
Evolutionary Process ◽  
Growth Patterns ◽  
Industry Dynamics ◽  
Good Representation ◽  
New Firms ◽  
Initial Size ◽  
Mortality Hazard ◽  
Age Dependent ◽  
Post Entry ◽  
New Literature

A number of studies have been undertaken on industry dynamics or about the process by which new firms either survive and grow, or else exit from the industry. A new literature has emerged in the last few years, which focuses on the question, what happens to new firms subsequent to their entry?, both in terms of their likelihood of survival and their growth patterns. Most of the studies use a theory of organisational ecology by Hannan and Freeman (1989), which emphasises organisational characteristics and environmental conditions; particularly the number of employees and invested capital. In addition, the theory offers a comprehensive set of factors that influence the hazard rate of newly founded business organisations. In particular, this theory deals with the evolutionary process within or between populations of organisations observed over long periods of time [see also Singh and Lumsden (1990)]. Originally, Stinchcombe (1965) directed the attention of organisational theorists, based on a hypothesis of a "liability of newness", to the age-dependent decline in organisational death rates. A number of studies [Freeman, Carroll, and Hannan (1983)] found that the organisational death risk declines monotonically with age. Later, BrUderl and SchUssler (1990) also empirically tested the Stinchcombe's "liability of newness" hypothesis and showed that it is not a good representation of the mortality (hazard) of business organisations. Organisational ecologists often discuss the "liability of smallness" in connection with the liability of newness [Aldrich and Auster (1986); Briiderl and SchUssler (1990); Audretsch and Mahmood (1994)]. The assumption is that large new businesses have better survival prospects than small new businesses. Initial size may be measured in terms of either the amount of financial capital or the number employed at the time of founding.

Diagnostic Value of Electron Microscopy in Soft Tissue Tumors

1970 ◽  
Vol 28 ◽  
pp. 220-221
Author(s):  
Gerald Fine ◽  
Azorides R. Morales
Keyword(s):  
Cardiac Myxoma ◽  
Osteogenic Sarcoma ◽  
Diagnostic Value ◽  
Soft Tissue Tumors ◽  
Amelanotic Melanoma ◽  
Growth Patterns ◽  
Light Microscopic Level ◽  
Mesenchymal Tumors ◽  
Good Agreement

For years the separation of carcinoma and sarcoma and the subclassification of sarcomas has been based on the appearance of the tumor cells and their microscopic growth pattern and information derived from certain histochemical and special stains. Although this method of study has produced good agreement among pathologists in the separation of carcinoma from sarcoma, it has given less uniform results in the subclassification of sarcomas. There remain examples of neoplasms of different histogenesis, the classification of which is questionable because of similar cytologic and growth patterns at the light microscopic level; i.e. amelanotic melanoma versus carcinoma and occasionally sarcoma, sarcomas with an epithelial pattern of growth simulating carcinoma, histologically similar mesenchymal tumors of different histogenesis (histiocytoma versus rhabdomyosarcoma, lytic osteogenic sarcoma versus rhabdomyosarcoma), and myxomatous mesenchymal tumors of diverse histogenesis (myxoid rhabdo and liposarcomas, cardiac myxoma, myxoid neurofibroma, etc.)

Effects of Hyperoxia on Lung Utrastructure

1970 ◽  
Vol 28 ◽  
pp. 26-27
Author(s):  
Gladys Harrison
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Light Microscopy ◽  
Oxygen Effects ◽  
Age Dependent ◽  
The Central Nervous System ◽  
The Subject ◽  
Space Age ◽  
Alveolar Septa ◽  
Extensive Damage

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.

1248: Impact of Surgical Treatment of Renal Carcinoma on Renal Function and Blood Pressure: A Race- and Age-Dependent Association

2007 ◽  
Vol 177 (4S) ◽  
pp. 411-412
Author(s):  
Javier Miller ◽  
Angela Smith ◽  
Kris Gunn ◽  
Erik Kouba ◽  
Eric M. Wallen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Surgical Treatment ◽  
Renal Carcinoma ◽  
Age Dependent
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