Diet Modifications to Control Hypertension: The Multifactorial Approach

2004 ◽  
pp. 155-167 ◽  
Author(s):  
Cheryl L. Rock
Keyword(s):  
Multifactorial Approach

Managing Cardiovascular Risk in Patients with Type 2 Diabetes – Challenges and Opportunities

2010 ◽  
Vol 6 (4) ◽  
pp. 31
Author(s):  
Lars Rydén ◽  
Linda Mellbin ◽  
Klas Malmberg ◽  
◽  
◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Clinical Trial Data ◽  
Oral Glucose ◽  
Lifestyle Modifications ◽  
Oral Glucose Tolerance Testing ◽  
Coronary Death ◽  
Increased Risk ◽  
Challenges And Opportunities ◽  
Patients With Diabetes ◽  
Multifactorial Approach

The prevalence of diabetes and its associated complications, such as cardiovascular disease (CVD), has increased over recent years and is expected to continue to rise dramatically. People with diabetes have a poor prognosis, with a substantially increased risk of coronary heart disease, coronary death, non-fatal myocardial infarction, stroke, and other vascular deaths compared with non-diabetic subjects. Conversely, studies have also shown that many patients with CVD have undiagnosed dysglycaemia and that already impaired glucose tolerance and newly detected diabetes are associated with an impaired prognosis. Thus, screening for such conditions, preferably with oral glucose tolerance testing, should be performed in all patients with CVD. Guidelines advocate a multifactorial approach to the management of prediabetes, diabetes and CVD. This includes lifestyle modifications as well as targets for glycaemic control, blood pressure, lipids, and other cardiometabolic risk factors. Although clinical trial data have demonstrated that target-driven strategies can improve outcomes in patients with diabetes, the implementation and execution of these regimens in clinical practice needs to improve.

Transitioning towards official clinical guidelines for the diagnostics and treatment of severe behavioural problems in children across Europe: current state and future directions.

2017 ◽  
Author(s):  
Alexandra-Raluca Gatej ◽  
Audri Lamers ◽  
Robert Vermeiren ◽  
Lieke van Domburgh
Keyword(s):  
Mental Health ◽  
Clinical Guidelines ◽  
Clinical Decision Making ◽  
Daily Practice ◽  
Clinical Decision ◽  
European Guidelines ◽  
Current State ◽  
Assessment And Treatment ◽  
Evidence Based Treatments ◽  
Multifactorial Approach

Severe behaviour problems (SBPs) in early childhood include oppositional and aggressive behaviours and predict negative mental health outcomes later in life. Although effective treatments for this group are available and numerous clinical practice guidelines have been developed to facilitate the incorporation of evidence-based treatments in clinical decision-making (NICE, 2013), many children with SBPs remain unresponsive to treatment (Lahey & Waldman, 2012). At present, it is unknown how many countries in Europe possess official clinical guidelines for SBPs diagnosis and treatment and what is their perceived utility. The aim was to create an inventory of clinical guidelines (and associated critical needs) for the diagnostics and treatment of SBPs in youth mental health across Europe according to academic experts and mental health clinicians’ opinions. To investigate the aim, two separate online semi-structured questionnaires were used, one directed at academics (N=28 academic experts; 23 countries), and the other at clinicians (N=124 clinicians; 24 countries). Three key results were highlighted. First, guidelines for SBPs are perceived as beneficial by both experts and clinicians. However, their implementation needs to be reinforced and content better adapted to daily practice. Improvements may include taking a multifactorial approach to assessment and treatment, involving the systems around the child, and multidisciplinary collaboration. Second, academic experts and clinicians support the need for further developing national / European guidelines. Finally, future guidelines should address current challenges identified by clinicians to be more applicable to daily practice.

scholarly journals FGF and Notch signaling in sensory neuron formation: A multifactorial approach to understanding signaling pathway hierarchy

2014 ◽  
Vol 134 ◽  
pp. 55-66 ◽  
Author(s):  
Jacob E. Voelkel ◽  
Jamison A. Harvey ◽  
Jason S. Adams ◽  
Rhonda N. Lassiter ◽  
Michael R. Stark
Keyword(s):  
Notch Signaling ◽  
Signaling Pathway ◽  
Sensory Neuron ◽  
Multifactorial Approach

scholarly journals Um Caso Raro de Dentes Neonatais

2015 ◽  
Vol 28 (6) ◽  
pp. 773 ◽  
Author(s):  
Andreia A. Martins ◽  
Cláudia Ferraz ◽  
Rute Vaz
Keyword(s):  
Conservative Treatment ◽  
Oral Cavity ◽  
Premature Infant ◽  
Premature Infants ◽  
Clinical Case ◽  
Treatment Decision ◽  
Tooth Eruption ◽  
Rare Disorder ◽  
Multifactorial Approach ◽  
Anterior Mandible

<p>Neonatal teeth is a rare disorder of tooth eruption, arising in the oral cavity, usually in the anterior mandible, in the first month of life. Its etiology is unknown. This condition can cause breastfeeding difficulties, besides aspiration or swallowing of the teeth. We describe the case of a premature infant in the second day of life presented with gingival edema, redness and discrete swelling in the region of the mandibular central incisors. Ten days later, two small teeth with hypermobility were detected. Extraction of those teeth was performed. With this clinical case we intend to show the rarity of this entity, especially in premature infants, the possible association with various syndromes and the need for a multifactorial approach to the treatment decision (extraction / conservative treatment).</p>

Progress in analgesic development: How to assess its real merits?

2021 ◽  
Vol 16 ◽  
Author(s):  
Igor Kissin
Keyword(s):  
Drug Evaluation ◽  
Previous Treatment ◽  
Widespread Application ◽  
Drug Candidates ◽  
Advantages And Disadvantages ◽  
Inflammatory Drugs ◽  
Pain Analgesics ◽  
Approved Drugs ◽  
Multifactorial Approach ◽  
Opioid Receptor Agonists

Background: Assessing analgesic drugs developed over preceding 50 years demonstrated that very intensive efforts directed at diverse molecular pain targets produced thousands of PubMed articles and the introduction of more than 50 new analgesics. Nevertheless, these analgesics did not have a sufficiently broad spectrum of action and level of effectiveness to demonstrably affect the use of opioids or nonsteroidal anti-inflammatory drugs for the treatment of pain. Analgesics in current are only modestly effective in chronic pain (at least with respect to neuropathic pain), and the widespread application of mu opioid receptor agonists for this purpose culminated in the global "opioid crisis”. The introduction of every new drug is regarded as an important success, at least initially. Assessing the merit of a new analgesic is extremely complicated. Objective: The aim of this article is to describe an approach that combines very different categories of drug evaluation – multifactorial approach to assessment of new analgesics. It is based on conclusiveness of clinical trials, novelty of a drug’s molecular target, a drug’s commercial appeal, and the interest in a drug reflected by scientometric indices. Results: This approach was applied to analgesics developed in 1982-2016. It shows that although several new agents have completely novel mechanisms of action, all newly approved drugs, and drug candidates, demonstrated the same persistent problems: relatively low therapeutic advantage over previous treatment and narrow spectrum of use in different types of pain, compared to opioids or NSAIDs. Conclusion: The use of the suggested multifactorial approach to drug assessment may provide a better view of the whole spectrum of analgesics advantages and disadvantages.

A MULTIFACTORIAL APPROACH FOR IMPROVING THE SURGICAL PERFORMANCE OF NOVICE VITREORETINAL SURGEONS

Retina ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Marina Roizenblatt ◽  
Kim Jiramongkolchai ◽  
Peter Louis Gehlbach ◽  
Vitor Dias Gomes Barrios Marin ◽  
Alex Treiger Grupenmacher ◽  
...  
Keyword(s):  
Surgical Performance ◽  
Multifactorial Approach

scholarly journals Implementation of a Market Entry Reward within the United States

2018 ◽  
Vol 46 (S1) ◽  
pp. 50-58 ◽  
Author(s):  
Gregory W. Daniel ◽  
Monika Schneider ◽  
Marianne Hamilton Lopez ◽  
Mark B. McClellan
Keyword(s):  
United States ◽  
Health Policy ◽  
Drug Development ◽  
Market Entry ◽  
The United States ◽  
Antimicrobial Drug ◽  
Multifactorial Approach

As part of a multifactorial approach to address weak incentives for innovative antimicrobial drug development, market entry rewards (MERs) are an emerging solution. Recently, the Duke-Margolis Center for Health Policy released the Priority Antimicrobial Value and Entry (PAVE) Award proposal, which combines a MER with payment reforms, transitioning from volume-based to “value-based” payments for antimicrobials. Here, the PAVE Award and similar MERs are reviewed, focusing on further refinement and avenues for implementation.

Full skeleton mean gait cycle description in normal population by means of integrated multifactorial approach

2008 ◽  
Vol 28 ◽  
pp. S34-S35
Author(s):  
M. D’Amico ◽  
G. D’Amico ◽  
P. Roncoletta ◽  
M. Paniccia ◽  
M. Vallasciani
Keyword(s):  
Gait Cycle ◽  
Normal Population ◽  
Multifactorial Approach
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