Transforming growth factor-β1, interleukin-10 and interferon-γ cytokine polymorphisms in patients with hereditary, familial and sporadic chronic pancreatitis

Pancreatology ◽  
2004 ◽  
Vol 4 (6) ◽  
pp. 490-494 ◽  
Author(s):  
Alexander Schneider ◽  
M. Michael Barmada ◽  
Adam Slivka ◽  
John A. Martin ◽  
David C. Whitcomb
Keyword(s):  
Chronic Pancreatitis ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Transforming Growth Factor Β1

scholarly journals Role of Vitamin D in Premature Atherosclerosis in Adolescents Type 1 Diabetes through Transforming Growth Factor-β1, Interferon-γ, Interleukin-10, and Interleukin-17

2020 ◽  
Vol 8 (B) ◽  
pp. 738-746
Author(s):  
Haryudi Aji Cahyono ◽  
Wisnu Barlianto ◽  
Dian Handayani ◽  
Handono Kalim
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Transforming Growth Factor Β1 ◽  
Premature Atherosclerosis ◽  
Ifn Γ ◽  
Tgf Β1

BACKGROUND: Cardiovascular disease (CVD) is one the cause of mortality in patients with type 1 diabetes (T1D). The development of CVD is mainly triggered by atherosclerosis, which is associated with the inflammatory process. AIM: The current study was aimed to investigate the association of Vitamin D level and premature atherosclerosis in adolescents with T1D, mainly through the regulation of various cytokines (interferon-γ [IFN-γ], IL-17, interleukin-10 [IL-10], and transforming growth factor-β1 [TGF-β1]). METHODS: This study was designed as a cross-sectional study involving 40 T1D and 40 healthy control who came to the outpatient clinic, Saiful Anwar Hospital, Malang, Indonesia, within the study period (January 2019-July 2019). RESULTS: Our data demonstrated that the IFN-γ and IL-17 levels were significantly higher (p < 0.001), whereas the TGF-β1 and IL-10 levels were significantly lower (p < 0.001) in T1D group compared with control. Furthermore, T1D also has higher carotid intima-media thickness (cIMT) value and lower flow-mediated dilatation (FMD) value compared to the control group (p < 0.001). Level of 25(OH)D3 was strongly associated with reduced cIMT and elevated FMD (p < 0.005). The direct effect of 25(OH)D3 on cIMT and FMD was higher than the indirect effect of Vitamin D through TGF-β1, IL-10, IL-17, and IFN-γ. The cutoff value of 25(OH)D3 levels for the risk of atherosclerosis was 12.8 ng/dL (sensitivity 85.7% and specificity 86.7%). CONCLUSION: The level of Vitamin D in the T1D group was significantly lower than those in healthy children and Vitamin D deficiency substantially influences the formation of premature atherosclerosis.

Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1

2020 ◽  
Vol 98 (6) ◽  
pp. 863-874
Author(s):  
Ying-Chun Ren ◽  
Qiuyan Zhao ◽  
Yan He ◽  
Bin Li ◽  
Zengkai Wu ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1

Adalimumab and methotrexate affect the concentrations of regulatory cytokines (interleukin‐10, transforming growth factor‐β1, and interleukin‐35) in patients with plaque psoriasis

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Natalia Zdanowska ◽  
Agnieszka Owczarczyk‐Saczonek ◽  
Joanna Czerwińska ◽  
Jacek J. Nowakowski ◽  
Anna Kozera‐Żywczyk ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plaque Psoriasis ◽  
Transforming Growth Factor ◽  
Interleukin 10 ◽  
Transforming Growth Factor Β1
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