scholarly journals Clinical Significance of Serum Oxidized Low-Density Lipoprotein/β2-Glycoprotein I Complexes in Patients with Chronic Renal Diseases

2004 ◽  
Vol 98 (1) ◽  
pp. c15-c24 ◽  
Author(s):  
Junko Kasahara ◽  
Kazuko Kobayashi ◽  
Yohei Maeshima ◽  
Yasushi Yamasaki ◽  
Tatsuji Yasuda ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Renal Diseases ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Glycoprotein I ◽  
Chronic Renal Diseases

Clinical Significance of the Antibody against Oxidized Low-Density Lipoprotein in Acute Myocardial Infarction

Cardiology ◽  
2002 ◽  
Vol 98 (1-2) ◽  
pp. 13-17 ◽  
Author(s):  
Teruo Inoue ◽  
Isao Yaguchi ◽  
Toshihiko Uchida ◽  
Hirotoshi Kamishirado ◽  
Shiro Nakahara ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

scholarly journals Predictive Value of Oxidized Low-Density Lipoprotein/β2-Glycoprotein-I Complexes (oxLDL/β2GPI) in Nonautoimmune Atherothrombosis

2018 ◽  
Vol 24 (7) ◽  
pp. 1050-1055
Author(s):  
Paul R. J. Ames ◽  
Giuseppe Di Girolamo ◽  
Giovanna D’Andrea ◽  
Luis R. Lopez ◽  
Giovanni Gaeta ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Multivariable Analysis ◽  
Density Lipoprotein ◽  
Cell Types ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Cross Sectional ◽  
Lipid Status ◽  
Glycoprotein I ◽  
Fourth Quartile

Introduction: Lipid oxidation is a definite feature of atherosclerosis, and oxidized low-density lipoprotein (oxLDL) is not only highly immunogenic but toxic to several cell types. Beta-2-glycoprotein-I (β2GPI) dampens oxLDL toxicity by forming binary oxLDL/β2GPI complexes. We evaluated whether circulating oxLDL/β2GPI complexes are associated to atherosclerosis-related events (ARE) and to venous thromboembolism (VTE). Methods: In a cross-sectional case–control study, cases were (a) 57 consecutive patients (male/female [M/F] 33/24, mean age 57 [10] years) attending a thrombosis unit for ARE (myocardial infarction [MI] n = 20, peripheral vascular disease n = 7, and ischemic strokes n = 30); (b) 52 consecutive patients (M/F 22/30, mean age 55 [17] years) attending the same unit for unprovoked (VTE); (c) normal controls comprised 90 participants (M/F 35/55, mean age 41 [15] years); and (d) oxLDL/β2GPI complexes were measured by immunoassay and resulting levels divided into quartiles. Results: The odds ratio (OR) of ARE was greater in the fourth and second quartiles than in the first quartile (8.5 and 6.0, respectively); the OR of developing MI was greatest in the fourth quartile (17.8). By multivariable analysis with age, sex, smoking, lipid status, statin, and ARE phenotypes as independent variables and oxLDL/β2GPI as the dependent variable, only MI predicted oxLDL/β2GPI ( P < .0001). Conclusions: OxLDL/β2GPI may be regarded as a marker of ARE, in particular of MI.

Sign in / Sign up

Export Citation Format

Share Document