Galanin-Like Peptide mRNA Alterations in Arcuate Nucleus and Neural Lobe of Streptozotocin-Diabetic and Obese Zucker Rats

2004 ◽  
Vol 79 (6) ◽  
pp. 327-337 ◽  
Author(s):  
Jun Shen ◽  
Andrew L. Gundlach
Keyword(s):  
Arcuate Nucleus ◽  
Zucker Rats ◽  
Neural Lobe

CENTRAL INSULIN ADMINISTRATION REDUCES NEUROPEPTIDE Y mRNA EXPRESSION IN THE ARCUATE NUCLEUS OF FOOD-DEPRIVED LEAN (Fa/Fa) BUT NOT OBESE (fa/fa) ZUCKER RATS

Endocrinology ◽  
1991 ◽  
Vol 128 (5) ◽  
pp. 2645-2647 ◽  
Author(s):  
Michael W. Schwartz ◽  
Jonathan L. Marks ◽  
Alfred J. Sipolst ◽  
Denis G. Basking ◽  
Stephen C. Woods ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Mrna Expression ◽  
Arcuate Nucleus ◽  
Zucker Rats ◽  
Insulin Administration

Ultrastructural Localization of Acetylcholinesterase in the Arcuate Nucleus and Median Eminence of the Rat

1977 ◽  
Vol 35 ◽  
pp. 440-441
Author(s):  
K.A. Carson ◽  
C.B. Nemeroff ◽  
M.S. Rone ◽  
J.S. Kizer ◽  
J.S. Hanker
Keyword(s):  
Choline Acetyltransferase ◽  
Median Eminence ◽  
Arcuate Nucleus ◽  
Cholinergic Neurons ◽  
Ultrastructural Localization ◽  
Male Rats ◽  
Neonatal Rats ◽  
Good Marker ◽  
Chemical Studies ◽  
High Doses

Biochemical, physiological, pharmacological, and more recently enzyme histo- chemical data have indicated that cholinergic circuits exist in the hypothalamus. Ultrastructural correlates of these pathways such as acetylcholinesterase (AchE) positive neurons in the arcuate nucleus (ARC) and stained terminals in the median eminence (ME) have yet to be described. Initial studies in our laboratories utilizing chemical lesioning and microdissection techniques coupled with microchemical and light microscopic enzyme histo- chemical studies suggested the existence of cholinergic neurons in the ARC which project to the ME (1). Furthermore, in adult male rats with Halasz deafferentations (hypothalamic islands composed primarily of the isolated ARC and the ME) choline acetyltransferase (ChAc) activity, a good marker for cholinergic neurons, was not significantly reduced in the ME and was only somewhat reduced in the ARC (2). Treatment of neonatal rats with high doses of monosodium 1-glutamate (MSG) results in a lesion largely restricted to the neurons of the ARC.

Insulin regulated aminopeptidase (IRAP) inhibition affects glucose metabolism in obese pre-diabetic Zucker rats

2020 ◽  
Author(s):  
Katarina Krskova ◽  
Lucia Balazova ◽  
Viktoria Dobrocsyova ◽  
Erika Balogova ◽  
Maciej Suski ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Zucker Rats

Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances

Diabetes ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1423-1429 ◽  
Author(s):  
P. E. McKibbin ◽  
S. J. Cotton ◽  
S. McMillan ◽  
B. Holloway ◽  
R. Mayers ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Zucker Rats
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