Evaluation of Stroke Volume via Arterial Pulse Pressure Waveforms in Neonatal Lambs

Neonatology ◽  
2004 ◽  
Vol 86 (3) ◽  
pp. 184-194 ◽  
Author(s):  
Sherri Kappler ◽  
Jay M. Milstein ◽  
Anita J. Moon-Grady ◽  
Stephen H. Bennett
Keyword(s):  
Stroke Volume ◽  
Pulse Pressure ◽  
Arterial Pulse ◽  
Arterial Pulse Pressure ◽  
Neonatal Lambs

EVALUATION OF STROKE VOLUME VIA ARTERIAL PULSE PRESSURE WAVEFORMS IN NEONATAL LAMBS.

2004 ◽  
Vol 52 ◽  
pp. S119
Author(s):  
S. Kappler ◽  
J. M. Milstein ◽  
A. J. Moon-Grady ◽  
S. H. Bennett
Keyword(s):  
Stroke Volume ◽  
Pulse Pressure ◽  
Arterial Pulse ◽  
Arterial Pulse Pressure ◽  
Neonatal Lambs

229 EVALUATION OF STROKE VOLUME VIA ARTERIAL PULSE PRESSURE WAVEFORMS IN NEONATAL LAMBS.

2004 ◽  
Vol 52 (Suppl 1) ◽  
pp. S119.3-S119
Author(s):  
S. Kappler ◽  
J. M. Milstein ◽  
A. J. Moon-Grady ◽  
S. H. Bennett
Keyword(s):  
Stroke Volume ◽  
Pulse Pressure ◽  
Arterial Pulse ◽  
Arterial Pulse Pressure ◽  
Neonatal Lambs

scholarly journals Relationship between Stroke Volume and Pulse Pressure during Blood Volume Perturbation: A Mathematical Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Ramin Bighamian ◽  
Jin-Oh Hahn
Keyword(s):  
Stroke Volume ◽  
Blood Volume ◽  
Fluid Therapy ◽  
Pulse Pressure ◽  
Mathematical Analysis ◽  
Left Ventricular ◽  
Experimental Investigations ◽  
Arterial Pulse ◽  
Arterial Pulse Pressure ◽  
Relative Change

Arterial pulse pressure has been widely used as surrogate of stroke volume, for example, in the guidance of fluid therapy. However, recent experimental investigations suggest that arterial pulse pressure is not linearly proportional to stroke volume. However, mechanisms underlying the relation between the two have not been clearly understood. The goal of this study was to elucidate how arterial pulse pressure and stroke volume respond to a perturbation in the left ventricular blood volume based on a systematic mathematical analysis. Both our mathematical analysis and experimental data showed that the relative change in arterial pulse pressure due to a left ventricular blood volume perturbation was consistently smaller than the corresponding relative change in stroke volume, due to the nonlinear left ventricular pressure-volume relation during diastole that reduces the sensitivity of arterial pulse pressure to perturbations in the left ventricular blood volume. Therefore, arterial pulse pressure must be used with care when used as surrogate of stroke volume in guiding fluid therapy.

A questionable association of stroke volume and arterial pulse pressure under gravitational stress

2012 ◽  
Vol 72 (3) ◽  
pp. 708-712 ◽  
Author(s):  
Anita T. Cote ◽  
Aaron A. Phillips ◽  
Shannon S. D. Bredin ◽  
Darren E. R. Warburton
Keyword(s):  
Stroke Volume ◽  
Pulse Pressure ◽  
Arterial Pulse ◽  
Arterial Pulse Pressure ◽  
Gravitational Stress

Arterial pulse pressure and vasopressin release in humans during lower body negative pressure

1993 ◽  
Vol 264 (5) ◽  
pp. R1024-R1030 ◽  
Author(s):  
P. Norsk ◽  
P. Ellegaard ◽  
R. Videbaek ◽  
C. Stadeager ◽  
F. Jessen ◽  
...  
Keyword(s):  
Pulse Pressure ◽  
Negative Pressure ◽  
Lower Body Negative Pressure ◽  
Venous Pressure ◽  
Plasma Norepinephrine ◽  
Lower Body ◽  
Arterial Pulse ◽  
Vasopressin Release ◽  
Arterial Pulse Pressure ◽  
Arterial Plasma

The hypothesis was tested that narrowing of arterial pulse pressure (PP) is a determinant of arginine vasopressin (AVP) release in humans. Six normal males completed a two-step lower body negative pressure (LBNP) protocol of -20 and -50 mmHg, respectively, for 10 min each. None of these subjects experienced presyncopal symptoms. Arterial plasma AVP and plasma renin activity (PRA) (at 2-min intervals) only increased subsequent to a decrease in PP (invasive brachial arterial measurements) and stroke volume (ultrasound Doppler technique, n = 4). Simultaneously, mean arterial pressure did not change. A selective decrease in central venous pressure and left atrial diameter (echocardiography, n = 4) at LBNP of -20 mmHg did not affect AVP or PRA, whereas arterial plasma norepinephrine increased (n = 4). During LBNP, significant (P < 0.05) intraindividual linear correlations were observed between log(AVP) and PP in four of the subjects with r values from -0.75 to -0.99 and between log(PRA) and PP in all six subjects with r values from -0.89 to -0.98. In conclusion, these results are in compliance with the hypothesis that narrowing of PP in humans during central hypovolemia is a determinant of AVP and renin release.

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