Noradrenaline Decreases Spike Voltage Threshold and Induces Electrographic Sharp Waves in Turtle Medial Cortex in vitro

2004 ◽  
Vol 64 (2) ◽  
pp. 104-114 ◽  
Author(s):  
Daniel Lorenzo ◽  
Julio C. Velluti
Keyword(s):  
Voltage Threshold ◽  
Sharp Waves ◽  
Medial Cortex

Different functions of hyperpolarization-activated cation channels for hippocampal sharp waves and ripples in vitro

Neuroscience ◽  
2013 ◽  
Vol 228 ◽  
pp. 325-333 ◽  
Author(s):  
S.A. Kranig ◽  
N. Duhme ◽  
C. Waldeck ◽  
A. Draguhn ◽  
S. Reichinnek ◽  
...  
Keyword(s):  
Cation Channels ◽  
Sharp Waves

scholarly journals An In Vitro Model of Hippocampal Sharp Waves: Regional Initiation and Intracellular Correlates

2005 ◽  
Vol 94 (1) ◽  
pp. 741-753 ◽  
Author(s):  
Chiping Wu ◽  
Marjan Nassiri Asl ◽  
Jesse Gillis ◽  
Frances K. Skinner ◽  
Liang Zhang
Keyword(s):  
Dentate Gyrus ◽  
Large Amplitude ◽  
Pyramidal Neurons ◽  
Slow Wave Sleep ◽  
Hippocampal Slices ◽  
Field Potentials ◽  
Sharp Wave ◽  
Sharp Waves ◽  
Hippocampal Circuitry

During slow wave sleep and consummatory behaviors, electroencephalographic recordings from the rodent hippocampus reveal large amplitude potentials called sharp waves. The sharp waves originate from the CA3 circuitry and their generation is correlated with coherent discharges of CA3 pyramidal neurons and dependent on activities mediated by AMPA glutamate receptors. To model sharp waves in a relatively large hippocampal circuitry in vitro, we developed thick (1 mm) mouse hippocampal slices by separating the dentate gyrus from the CA2/CA1 areas while keeping the functional dentate gyrus-CA3-CA1 connections. We found that large amplitude (0.3–3 mV) sharp wave-like field potentials occurred spontaneously in the thick slices without extra ionic or pharmacological manipulation and they resemble closely electroencephalographic sharp waves with respect to waveform, regional initiation, pharmacological manipulations, and intracellular correlates. Through measuring tissue O2, K+, and synaptic and single cell activities, we verified that the sharp wave-like potentials are not a consequence of anoxia, nonspecific elevation of extracellular K+ and dissection-related tissue damage. Our data suggest that a subtle but crucial increase in the CA3 glutamatergic activity effectively recruits a population of neurons thus responsible for the generation of the sharp wave-like spontaneous field potentials in isolated hippocampal circuitry.

scholarly journals Caffeine Increases Hippocampal Sharp Waves in Vitro

2017 ◽  
Vol 40 (7) ◽  
pp. 1111-1115 ◽  
Author(s):  
Yusuke Watanabe ◽  
Yuji Ikegaya
Keyword(s):  
Sharp Waves

Scaling of Network Excitability and Inhibition may Contribute to the Septotemporal Differentiation of Sharp Waves–Ripples in Rat Hippocampus In Vitro

Neuroscience ◽  
2021 ◽  
Vol 458 ◽  
pp. 11-30
Author(s):  
George Trompoukis ◽  
Leonidas J. Leontiadis ◽  
Pavlos Rigas ◽  
Costas Papatheodoropoulos
Keyword(s):  
Rat Hippocampus ◽  
Sharp Waves

scholarly journals Increased molecular plasticity along the septotemporal axis of the hippocampus is associated with network functioning

2019 ◽  
Author(s):  
Evangelos Sotiriou ◽  
Fevronia Angelatou ◽  
Costas Papatheodoropoulos
Keyword(s):  
Hippocampal Slices ◽  
Longitudinal Axis ◽  
Ventral Hippocampus ◽  
Network Activity ◽  
Molecular Organization ◽  
Dynamic Tuning ◽  
Sharp Waves ◽  
Neuronal Network Dynamics ◽  
Molecular Plasticity

AbstractMolecular plasticity crucially supports adaptive cellular and network functioning in the brain. Variations in molecular plasticity may yield important differences in neuronal network dynamics between discrete brain subregions. In the present study we show that the gradual development of sharp waves (SPWs), a spontaneous network activity that is organized under normalin vitroconditions in the CA1 field of ventral but not dorsal hippocampal slices, is associated with region selective molecular reorganization. In particular, increased levels of mRNAs for specific GABAAreceptor subunits (α1, β2, γ2) occurred in ventral hippocampal CA1 field during the development of SPWs. These mRNA changes were followed by a clear increase in GABAAreceptor number in ventral hippocampus, as shown by [3H]muscimol binding. An increase in mRNAs was also observed in dorsal slices for α2 and α5 subunits, not followed by quantitative GABAAreceptor changes. Furthermore, full development of SPWs in the CA1 field (at 3 hours of slice maintenancein vitro) was followed by increased expression of immediate early genes c-fos and zif-268 in ventral hippocampal slices (measured at 5 hoursin vitro). No change in c-fos and zif-268 levels is observed in the CA1 field of dorsal slices, which do not develop spontaneous activity. These results suggest that generation of SPWs could trigger specific molecular reorganization in the VH that may be related to the functional roles of SPWs. Correspondingly, the revealed increased potentiality of the ventral hippocampus for molecular reorganization may provide a clue to mechanisms that underlie the regulated emergence of SPWs along the longitudinal axis of the hippocampus. Furthermore, the present evidence suggests that dynamic tuning between spontaneous neuronal activity and molecular organization may importantly contribute to the functional segregation/heterogeneity seen along the hippocampus.

scholarly journals Loss of the Kv1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices

2013 ◽  
Vol 54 ◽  
pp. 68-81 ◽  
Author(s):  
Timothy A. Simeone ◽  
Kristina A. Simeone ◽  
Kaeli K. Samson ◽  
Do Young Kim ◽  
Jong M. Rho
Keyword(s):  
Potassium Channel ◽  
High Frequency ◽  
Hippocampal Slices ◽  
Sharp Waves ◽  
High Frequency Oscillations

Homo- and heterosynaptic long-term potentiation in the medial cortex of the turtle brain in vitro

1998 ◽  
Vol 807 (1-2) ◽  
pp. 155-159 ◽  
Author(s):  
Marı́a-Dolores Muñoz ◽  
José-Marı́a Gaztelu ◽  
Elio Garcı́a-Austt
Keyword(s):  
Long Term Potentiation ◽  
Medial Cortex ◽  
Term Potentiation
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